Changes in salivary composition in patients with renal failure

Hepatocyte Growth Factor in Saliva of Patients with Renal Failure and Periodontal Disease

“…In most cases, examined groups were characterized by a considerably younger age, probably better clinical status and rarer coexistence of diabetes, atherosclerosis, and cardiovascular complications. [12][13][14][15][16][17][18][19][20][21][22] Erythropoietin therapy was not taken into consideration in previous investigations of periodontal and dental status of HD patients, leading not only to considerable improvement of anemia but also to general and local immunity.…”

“…[12][13][14][15][16][17][18][19][20][21][22] They were conducted in small groups of patients, mainly chronic hemodialysis (HD) patients, and gave ambiguous results. However, a number of significant disorders (Table 1) indicating a worse condition of teeth and more advanced PD in HD patients compared to general population were found.…”

“…21 The results of previous clinical researches showed that the PD is a significant health problem in CRF patients. [12][13][14][15][16][17][18][19][20][21][22] Risk factors of its accelerated development in this population are presence of uremic toxins, humoral and cell immunity disorders, anemia, malnutrition, vitamin D deficiency, secondary parathyroid gland hyperfunction, osteoporosis and other bone metabolism disorders, insulin resistance or diabetes, liver lesion in the course of frequent viral infections, as well as condition of general disability impairing the care for oral hygiene. [12][13][14][15][16][17][18][19][20][21][22] The role of growth factors in the pathogenesis of PD in CRF patients was not subject to research so far.…”

“…[12][13][14][15][16][17][18][19][20][21][22] Risk factors of its accelerated development in this population are presence of uremic toxins, humoral and cell immunity disorders, anemia, malnutrition, vitamin D deficiency, secondary parathyroid gland hyperfunction, osteoporosis and other bone metabolism disorders, insulin resistance or diabetes, liver lesion in the course of frequent viral infections, as well as condition of general disability impairing the care for oral hygiene. [12][13][14][15][16][17][18][19][20][21][22] The role of growth factors in the pathogenesis of PD in CRF patients was not subject to research so far. Systemic activation of the HGF/c-Met system generally found in these patients, 8,[21][22][23][24][25][26][27] in particular under the influence of heparin administrated for the purpose of anticoagulation of blood during HD treatments, [25][26][27] may be a significant element in the development and progression of PD.…”

Effects of Expelling of Induced Hypersalivation on Serum Phosphorus, Urea and Creatinine Levels in End Stage Renal Disease Patients

“…Phosphate may be secreted in the saliva, which is then swallowed, and this provides a source of endogenous phosphate and thus contributes to the hyperphosphatemia in ESRD. The level of salivary phosphate may provide a better marker than serum phosphate for the initiation of treatment of hyperphosphatemia in ESRD and hemodialysis (HD) patients (6,7) . The results may also offer a new horizon in the therapy of hyperphosphatemia by inducing hyper salivation.…”