Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis

Domitrz, Izabela; Koter, Marek; Chołojczyk, Małgorzata; Domitrz, Wojciech; Barańczyk‐Kuźma, Anna; Kamińska, Anna

doi:10.2174/1871527314666150225144300

Cited by 6 publications

(4 citation statements)

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“…Moreover, their different pathogeneses have been demonstrated. Domitrz et al (2015) found a higher level of histidine in subjects with migraine without and with aura and a lower level of valine and leucine in subjects with migraine without aura. Higher plasma glutamine and aspartic acid levels have also been found in patients with migraine (notably with aura) between attacks (Ferrari et al, 1990).…”

Section: Discussionmentioning

confidence: 81%

Contingent negative variation for the periodicity of migraine attacks without aura

Tian

Guo

et al. 2019

J. Integr. Neurosci.

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Migraine is a primary neuropsychological disorder, although its etiology and pathogenesis are unknown. It has been reported that using contingent negative variation, the periodicity of migraine attacks is three days in adults. However, there is still a lack of relevant reports about the periodicity of migraine without aura in adults. Therefore, we investigated the changes of contingent negative variation in adults with migraine without aura from three to seven days after migraine attacks in order to provide the basis for exploring the circulation periodicity of migraine without aura. This prospective, observational study involved a group of 34 individuals with migraine without aura, who were screened during the three to seven days after a migraine attack without aura. A healthy group (31 individuals) was used as controls to assess the amplitudes of contingent negative variation and habituation of early contingent negative variation. Indices of the amplitudes included overall contingent negative variation, initial contingent negative variation, terminal contingent negative variation, and postoperative negative contingent variation. Differences between these indicators were analyzed. No significant difference was found between the patient and control groups for either the amplitudes of these measures of contingent negative variation or habituation of the early contingent negative variation for three to seven days after a migraine attack without aura (all P > 0.05). Thus, the study reported here found that the periodicity of migraine attacks without aura in adults is more than three days.

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Section: Discussionmentioning

confidence: 81%

Contingent negative variation for the periodicity of migraine attacks without aura

Tian

Guo

et al. 2019

J. Integr. Neurosci.

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“…Leucine, isoleucine and valine are branched-chain amino acids (BCAAs), BCAAs have emerged as potential biomarkers of disease as they are associated with risk of cardiovascular disease, end-stage renal failure, and ischemic stroke [ 67 ]. In a small study of 37 migraine patients and 40 controls elevated levels of isoleucine in blood serum were found [ 68 ]. A recent study investigated amine pathways in 20 patients with migraine without aura, and 20 healthy subjects in serum with liquid chromatography coupled to mass spectrometry (LC-MS) [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy

Harder

Vijfhuizen

Henneman³

et al. 2021

J Headache Pain

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Background Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear magnetic resonance (1H-NMR) spectroscopy, metabolites in serum that are associated with lifetime and active migraine by comparing metabolic profiles of patients and controls. Methods Fasting serum samples from 313 migraine patients and 1512 controls from the Erasmus Rucphen Family (ERF) study were available for 1H-NMR spectroscopy. Data was analysed using elastic net regression analysis. Results A total of 100 signals representing 49 different metabolites were detected in 289 cases (of which 150 active migraine patients) and 1360 controls. We were able to identify profiles consisting of 6 metabolites predictive for lifetime migraine status and 22 metabolites predictive for active migraine status. We estimated with subsequent regression models that after correction for age, sex, BMI and smoking, the association with the metabolite profile in active migraine remained. Several of the metabolites in this profile are involved in lipid, glucose and amino acid metabolism. Conclusion This study indicates that metabolic profiles, based on serum concentrations of several metabolites, including lipids, amino acids and metabolites of glucose metabolism, can distinguish active migraine patients from controls.

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“…Interesting observations were demonstrated in another article [27] based on the previously described research by D' Andrea et al Researchers aimed to verify the hypothesis of a similar pathogenesis of ED to migraine, which suggests catecholamine and trace amine dysregulation in both diseases. Since this has been demonstrated to play a role in migraine [28,29], similar observations in ED would allow better understanding of some consistent mechanisms underlying both disorders. Therefore, plasma levels of dopamine (DA), noradrenaline (NA), tyrosine (Tyr), and octopamine (Oct) were measured in BN and AN patients, and compared to healthy controls.…”

Section: Migraine and Eating Disorders Are Presumably Correlatedmentioning

confidence: 77%

Is there a correlation between migraine and eating disorders? A systematic literature review

Łangowska-Grodzka,

Grodzka,

Czarnecki

et al. 2023

Neurol Neurochir Pol.

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Introduction.Migraine is a common primary headache disorder, which affects mainly young females, usually those with some specific personality traits including neuroticism and obsessive-compulsive disorder. Among many factors that may trigger headache are to be found those associated with eating patterns and behaviours.Eating disorders are psychiatric disorders of abnormal eating or weight-control behaviours. According to the most up-to-date classification, six main types are identified, including anorexia nervosa, bulimia nervosa, and binge eating disorder. Similar to migraine, eating disorders are mainly diagnosed in young adults and, moreover, personality pattern, in at least some of the eating disorders, is also suggested to be consistent. Material and methods.This systematic review aimed to summarise the available literature related to this topic. We performed an electronic article search through the Embase, PubMed, and Cochrane databases and included 16 articles into analysis in accordance with PRISMA 2020 guidelines. Results.Most of the studies revealed the presence of a putative correlation between migraine and eating disorders, and these encourage further investigations. Moreover, apart from the clinical aspect, also the pathogenesis underlying both disorders is suggested to be similar. More frequent co-occurrence of other psychiatric disorders in migraineurs, such as depression and anxiety, was reported and should be considered in future research. Furthermore, adverse interactions between pharmacotherapy and symptoms of comorbid conditions underline the importance of this problem. Conclusions.A correlation between migraine and eating disorders appears highly probable. However, further investigations are required focusing on diverse aspects such as clinical, psychological, and pathogenic.

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Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis

Abstract: We found higher level of His in migraine patients without and with aura and lower level of Val and Leu in patients with migraine without aura.

Cited by 6 publications

References 0 publications

Contingent negative variation for the periodicity of migraine attacks without aura

Contingent negative variation for the periodicity of migraine attacks without aura

Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy

Is there a correlation between migraine and eating disorders? A systematic literature review

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