Changes in Serum Anti-Müllerian Hormone Level during Low-Dose Recombinant Follicular-Stimulating Hormone Therapy for Anovulation in Polycystic Ovary Syndrome

Catteau-Jonard, Sophie; Pigny, Pascal; Reyss, Anne-Céline; Decanter, Christine; Poncelet, E.; Dewailly, Didier

doi:10.1210/jc.2007-0868

Cited by 69 publications

(29 citation statements)

References 30 publications

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“…A plausible hypothesis for this figure is that the increased AMH levels in PCOS are the results of the increased number of small ovarian follicles [29,30]. In this regard, a direct and a significant correlation between follicle number and serum AMH levels has been demonstrated by some authors [8-10,12], even if the hypotheses provided for this correlation were not univocal [27,28]. …”

Section: Discussionmentioning

confidence: 99%

Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin

et al. 2010

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BackgroundNo data regarding metformin effects on follicular fluid anti-Müllerian hormone (AMH) levels were to date available in literature. The aim of the present study was to evaluate in patients with polycystic ovary syndrome (PCOS) whether metformin administration affects serum and follicular AMH levels, and whether this is related to ovarian response to the treatment.MethodsTwenty young patients with PCOS who had received metformin were enrolled. Ten patients were anovulatory (Met-anov group), whereas the other 10 were ovulatory (Met-ov group) but had failed to conceive. Further untreated PCOS (PCOS controls, n. 10) and healthy controls (non-PCOS controls, n. 10) who were scheduled for laparoscopic surgery were enrolled. In each subjects, clinical and biochemical evaluations were performed. AMH concentrations in blood and antral follicular fluid were assayed.ResultsIn both Met-anov and Met-ov groups, and without difference between them, serum androgens and AMH, and indices of insulin resistance were significantly (p < 0.05) improved after treatment. On the other hand, significant differences (p < 0.05) between the two groups were detected with respect to the same biochemical parameters in antral follicular fluid. In the Met-anov group, no significant correlation was observed between AMH concentrations in the follicular fluid and variation in serum androgens, AMH and insulin resistance indexes; whereas in Met-ov group significant correlations were detected between AMH levels in the follicular fluid and variation in serum androgens, AMH and insulin resistance indexes.ConclusionsMetformin administration in patients with PCOS exerts a differential action on the ovarian AMH levels on the basis of ovulatory response. Changes in AMH levels in antral follicular fluid during metformin treatment could be involved in the local mechanisms mediating the ovulatory restoration.

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Section: Discussionmentioning

confidence: 99%

Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin

et al. 2010

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“…Previous studies in patients with PCOS by Li et al [15] reported a mean AMH level of 9.85 ng/mL while Catteau-Jonard et al [11] reported 6.59 ng/mL. Piltonen et al [16] concluded that the AMH level in patients with PCOS was always two or three times higher than the normal population (16–44 years).…”

Section: Discussionmentioning

confidence: 99%

“…This was demonstrated in a study using continuous low dose FSH recombinant therapy that resulted in a significantly decreased AMH level in the follicle. It was suggested that a decreased AMH level would lead to the suppression of the inhibitory mechanism in the follicle; thus it could then develop into a dominant follicle [11]. Amer et al [19] reported that after laparoscopic ovarian diathermy, the AMH level in subjects with ovulation was 25% lower than subjects with no ovulation.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate

Hestiantoro

Negoro

Afrita

et al. 2016

Clin Exp Reprod Med

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ObjectiveThis study aimed to determine the threshold of anti-Müllerian hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC).MethodsFifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed.ResultsThe AMH levels of patients with successful follicular growth were significantly lower (p=0.001) than those with unsuccessful follicular growth (6.10±3.52 vs. 10.43±4.78 ng/mL). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p=0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y=–2.35+(–0.312×AMH level)+(0.464×fiber intake) (area under the curve, 0.88; 95% confidence interval, 0.79–0.98; p<0.001).ConclusionThe optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.

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“…Catteau-Jonard et al investigated whether reduction of AMH production occurs in CC-resistant women with PCOS with at least one dominant follicle after low-dose step-up administration of FSH [27]. They found that a decrease in the serum AMH level was concomitant with the appearance of a dominant follicle.…”

Section: Discussionmentioning

confidence: 99%

Association between serum anti-Müllerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome

Kim

et al. 2013

Clin Exp Reprod Med

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ObjectiveTo evaluate the correlation between serum levels of anti-Müllerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS).MethodsSeventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (≥14 mm) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated.ResultsOvarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively).ConclusionOvarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.

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Changes in Serum Anti-Müllerian Hormone Level during Low-Dose Recombinant Follicular-Stimulating Hormone Therapy for Anovulation in Polycystic Ovary Syndrome

Abstract: These data suggest that in anovulatory women with PCOS, gently increasing the serum FSH level reduces the AMH excess, thus relieving the inhibition from the latter on aromatase expression by selectable follicles and allowing the emergence of a dominant follicle.

Cited by 69 publications

References 30 publications

Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin

Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin

Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate

Association between serum anti-Müllerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome

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