Changes in serum levels of angiopoietin-like protein-8 and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 after ezetimibe therapy in patients with dyslipidemia

Ideishi, Akihito; Suematsu, Yasunori; Tashiro, Kohei; Morita, Hidetaka; Kumagai-Koyanagi, Naoko; Kuwano, Takashi; Miura, Shin‐ichiro

doi:10.1016/j.cca.2020.08.030

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Serum betatrophin positively correlated with triglyceride in nondiabetic subjects and negatively correlated with HDL-C levels in nondiabetic subjects and T2D patients [23,24]. Moreover, significant positive correlation was found between serum betatrophin and triglyceride levels in a cohort including control subjects and patients with insulin resistance and sepsis [25] and in patients with metabolic syndrome [26]. We also found significant positive correlations between triglyceride and betatrophin levels, but only in the entire patient population and in females.…”

Section: Discussionsupporting

confidence: 51%

Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients

Lőrincz,

Csiha,

Ratku

et al. 2023

IJMS

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Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration.

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Section: Discussionsupporting

confidence: 51%

Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients

Lőrincz,

Csiha,

Ratku

et al. 2023

IJMS

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“…Recently, clinical studies have shown improvements in lipid metabolism with an anti-ANGPTL monoclonal antibody [27], and these are attracting attention to develop new therapeutic drugs. In addition, it was shown that ezetimibe, a lipid-improving drug, may lower ANGPTL8 levels [28]; this led to an increased interest in using ANGPTLs as a therapeutic target in clinical practice. The purpose of this study was thus to clarify the interactions among circulating ANGPTL3, 4, and 8 levels, their association with lipid and glucose metabolism markers, and the contributing factors to plasma TG levels in patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes

et al. 2021

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Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed. Members of the angiopoietin-like protein (ANGPTL) family, specifically ANGPTL3, 4, and 8, have been reported as factors that inhibit lipoprotein lipase (LPL) activity and affect TGs. The present study investigated the association between lipid and glucose metabolism markers and the mechanism by which these proteins affect lipid metabolism. A total of 84 patients hospitalized for diabetes treatment were evaluated. Lipid and glucose metabolism markers in blood samples collected before breakfast, on the day after hospitalization, were analyzed. ANGPTL8 showed a significant positive correlation with TG values. HDL-C values displayed a significant positive correlation with ANGPTL3 but a negative correlation with ANGPTL4 and ANGPTL8. The results did not indicate a significant correlation among ANGPTL3, 4, and 8 levels. Thus, it is possible that the distribution of these proteins differs among patients. When patients were divided into groups according to the levels of ANGPTL3 and ANGPTL8, those with high levels of both ANGPTL3 and ANGPTL8 also had high levels of TG and small dense LDL-C/LDL-C (%). Multiple regression analysis indicated that low LPL, high ApoC2, high ApoC3, high ApoE, and high ANGPTL8 levels were the determinants of fasting hypertriglyceridemia. By contrast, no clear association was observed between any of the ANGPTLs and glucose metabolism markers, but ANGPTL8 levels were positively correlated with the levels of HOMA2-IR and BMI. Patients with high levels of both ANGPTL3 and ANGPTL8 had the worst lipid profiles. Among ANGPTL3, 4, and 8, ANGPTL8 is more important as a factor determining plasma TG levels. We anticipate that the results of this research will facilitate potential treatments targeting ANGPTL8 in patients with diabetes.

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Relationship between serum Betatrophin, GPIHBP1, and LDL subfractions in patients with gestational diabetes mellitus

Saruhan

İspir

2023

Clinical Biochemistry

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Changes in serum levels of angiopoietin-like protein-8 and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 after ezetimibe therapy in patients with dyslipidemia

Cited by 5 publications

References 24 publications

Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients

Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients

Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes

Relationship between serum Betatrophin, GPIHBP1, and LDL subfractions in patients with gestational diabetes mellitus

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