Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Newport, A; Carter, Jan

doi:10.1530/jrf.0.0670433

Cited by 8 publications

(2 citation statements)

References 16 publications

(16 reference statements)

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“…It has been previously demonstrated that the proportion (Newport & Carter 1983) as well as the total number of B cells (Muzzio et al 2014) in the para-aortic lymph nodes (PLN) draining the uterus is increased during pregnancy. In this study we first confirmed this by showing that Marginal zone B cells 33 normal pregnant mice displayed a significantly higher number of B220 C CD21 C mature B cells in PLN compared to non-pregnant mice (Fig.…”

Section: Increased Number Of Mature B Cells In the Lymph Nodes Drainimentioning

confidence: 99%

Marginal zone B cells emerge as a critical component of pregnancy well-being

Muzzio¹,

Ziegler²,

Ehrhardt³

et al. 2016

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The success of eutherian mammal evolution was certainly supported by the ability of the already existing immune system to adapt to the presence of the semi-allogeneic fetus without losing the capability to defend the mother against infections. This required the acquisition of highly regulated and coordinated immunological mechanisms. Failures in the development of these strategies not only lead to the interruption of pregnancy but also compromise maternal health. Alongside changes on the cytokine profile -expansion of tolerogenic dendritic and regulatory T cells -a profound adaptation of the B cell compartment during pregnancy was recently described. Among others, the suppression of B cell lymphopoiesis and B cell lymphopenia were proposed to be protective mechanisms tending to reduce the occurrence of autoreactive B cells that might recognize fetal structures and put pregnancy on risk. On the other hand, expansion of the pre-activated marginal zone (MZ) B cell phenotype was described as a compensatory strategy launched to overcome B cell lymphopenia thus ensuring a proper defense. In this work, using an animal model of pregnancy disturbances, we demonstrated that the suppression of B cell lymphopoiesis as well as splenic B cell lymphopenia occur independently of pregnancy outcome. However, only animals undergoing normal pregnancies, but not those suffering from pregnancy disturbances, could induce an expansion and activation of the MZ B cells. Hence, our results clearly show that MZ B cells, probably due to the production of natural protective antibodies, participate in the fine balance of immune activation required for pregnancy well-being.

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Section: Increased Number Of Mature B Cells In the Lymph Nodes Drainimentioning

confidence: 99%

Marginal zone B cells emerge as a critical component of pregnancy well-being

Muzzio¹,

Ziegler²,

Ehrhardt³

et al. 2016

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“…Many hypotheses have been advanced as to the nature of this mechanism, but few have stood the test of time. Current opinion seems to favour a 'priming' of the maternal immune system, probably at the level of the regional lymph nodes draining the gravid uterus (Newport & Carter, 1983). Such priming involves antigen-presenting cells entering via the afferent lymphatic and/or the lymphocytes entering the node from the blood, the result being a carefully regulated response by the mother leading to tolerance.…”

Section: Introductionmentioning

confidence: 99%

A monoclonal antibody to an antigen present on the microvillous membrane of the trophectoderm of the preimplantation blastocyst of the pig

Whyte¹,

Bacon²,

Ellis³

1984

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Immunization of BALB/c mice with 14-day pig preimplantation blastocyst material followed by fusion of spleen cells with NS-0 myeloma cells resulted in a clone, SN 1/38, which secreted IgG1 which reacted specifically with the microvillous border of the pig trophectoderm and trophoblast as assessed by immunohistology. SN 1/38 did not react with other fetal tissues, or with blastocysts from other animal species. It was shown by absorption studies and by enzyme-linked immunoabsorbent assay that SN 1/38 was not directed against the placental form of pig alkaline phosphatase. The location of this antigen and its apparent presence throughout gestation indicate a functional role in the materno-fetal interaction.

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A comparison of anti-type II collagen antibody titres and isotype profiles in pregnant and virgin DBA/1 mice with collagen-induced arthritis

Williams

Whyte

1989

Journal of Reproductive Immunology

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Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Cited by 8 publications

References 16 publications

Marginal zone B cells emerge as a critical component of pregnancy well-being

Marginal zone B cells emerge as a critical component of pregnancy well-being

A monoclonal antibody to an antigen present on the microvillous membrane of the trophectoderm of the preimplantation blastocyst of the pig

A comparison of anti-type II collagen antibody titres and isotype profiles in pregnant and virgin DBA/1 mice with collagen-induced arthritis

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