Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

Langen, Marieke; Bos, Dienke J.; Noordermeer, Siri D. S.; Nederveen, Hilde; Engeland, Hermán van; Durston, Sarah

doi:10.1016/j.biopsych.2013.08.013

Cited by 206 publications

(172 citation statements)

References 56 publications

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“…The RRBs have also been linked to specific frontal lobe structural abnormalities (Ecker et al 2012), and the RRBs have been linked to atypical caudate overgrowth (Langen et al 2014). By contrast, Doyle-Thomas et al (2014) reported that RRBs in general were associated with atypically low choline/creatine in the thalamus, whereas ASD social impairment was not.…”

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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ASD research is at an important crossroads. The ASD diagnosis is important for assigning a child to early behavioral intervention and explaining a child's condition. But ASD research has not provided a diagnosis-specific medical treatment, or a consistent early predictor, or a unified life course. If the ASD diagnosis also lacks biological and construct validity, a shift away from studying ASD-defined samples would be warranted. Consequently, this paper reviews recent findings for the neurobiological validity of ASD, the construct validity of ASD diagnostic criteria, and the construct validity of ASD spectrum features. The findings reviewed indicate that the ASD diagnosis lacks biological and construct validity. The paper concludes with proposals for research going forward.Keywords DSM-5 . ASD . Autism . Diagnosis . Validity . Comorbidity . HeterogeneityThe goal of the DSM-3 nosology (American Psychiatric Association 1980) was to create reliable and standard categorical psychiatric diagnoses (Robins and Guze 1970). However, in the past 30 years, clinical, genetics, and neuroscience findings have revealed that the DSM diagnoses are not biologically valid. The National Institutes of Mental Health (NIMH) responded by proposing the Research Domain Criteria (RDoC) framework for a brain-based transdiagnostic psychiatric symptom nosology (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016). Peterson (2015) and Weinberger et al. (2015) argued that the RDoC could not replace the DSM-5 psychiatric nosology (American Psychiatric Association 2013) or the parallel International Classification of Diseases (ICD) psychiatric nosology (World Health Organization 2012). But BFor the foreseeable future, RDoC is not envisioned as a system of psychiatric classification in its own right. Instead, in the near term, RDoC and DSM-ICD are expected to coexist. Nevertheless, RDoC is intended to provide scaffolding for a large-scale research program that will ultimately yield an alternative to DSM-ICD^ (Lilienfeld and Treadway 2016, p. 445).RDoC advocates accept that DSM-5/ICD psychiatric categories remain necessary in clinical practice, but argue that researchers should shift to RDoC study designs immediately. They assert that studying psychiatric categories lacking biological validity blocks the discovery of brain bases for psychopathology and thus cannot lead to effective medical treatments for specific psychiatric symptoms (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016;Yee et al. 2015). Against this RDoC imperative for biological validity, Weinberger et al. (2015) countered that current DSM-5 psychiatric behavioral diagnoses were valid when they yielded effective medical treatment, clear prognosis, and a life course specific to a diagnosis.Autism spectrum disorder (ASD) research has been productive (Dawson 2016;de la Torre-Ubieta et al. 2016;Szatmari et al. 2016), but no ASD research findings have met the validity criteria of Weinberger et al. (2015). DSM-5 ASD research has found no s...

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Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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“…Finally the disruption of the "limbic" cortico-striatal loop will manifest clinically as addictive behaviour. In autism [11,12] the dopaminergic regulatory circuits are disrupted in all three areas [17,18].…”

Section: Similaritiesmentioning

confidence: 99%

Addiction and Autism: A Remarkable Comorbidity?

Cremers¹

2014

J Alcohol Drug Depend

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ObjectiveAutism Spectrum Disorders (ASD) are well known for high prevalence's of comorbid conditions especially anxiety, obsessions, depression and challenging behaviours. In this article we will consider the evidence for an eventual comorbidity between ASD and Addiction (Substance Use Disorders (SUD) and explore the possible underlying explanations. MethodsA literature study on similarities between Addiction and ASD (at a phenotypical and neurobiological level) as well as a case note review on a year cohort of 200 consecutive admissions in an adult addiction psychiatry unit was studied here. ResultsIn our pilot-survey 8 (men) on 118 patients were diagnosed with autism spectrum disorder. This is substantially higher than in the general population (1%) but in line with other European studies.Autism spectrum disorders and addiction can both be perceived as developmental disorders in which a genetic predisposition and vulnerability interact with environmental factors. They can be induced by early stress thus affecting the proper functioning of the cortico-striatal dopaminergic regulation systems (and also the HPA axis). There is growing evidence that ASD and SUD share developmental dysregulations of the limbic and sensorimotor cortico-striatal regulations loops. ConclusionsThere are clear indications that a possible comorbidity of substance abuse disorder should be considered in cases of individuals with autism spectrum disorders. This finding is important for clinicians to take into account in assessing patients with addiction problems or ASD.time frame, and take responsibility for oneself and others. He managed to get the shopping done in time but was tidying the purchased items when he was expected to join a group therapy session. When one of the nurses confronted him, he went out of his mind, became very aggressive and bashed doors and broke windows whilst threatening the nurse verbally. Due to this unacceptable behaviour he was dismissed from the program immediately. A week later he came back to our outpatient clinic and was asked what had happened and had caused his extreme reaction. He said that he became very angry because the nurse had interrupted him. For him it was inconceivable that he should have joined the group leaving his task unfinished. In the clinical interview it became clear that this type of rigid behaviour, and his incapacity

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“…A noteworthy exception to this is a recent study demonstrating an increased growth rate of the striatum in individuals with autism compared to typically developing controls. This faster striatal growth rate was correlated with greater severity of restricted, repetitive behavior (Langen et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Repetitive motor behavior: Further characterization of development and temporal dynamics

Muehlmann

Bliznyuk

Duerr

et al. 2015

Developmental Psychobiology

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Repetitive behaviors are diagnostic for autism spectrum disorders, common in related neurodevelopmental disorders, and normative in typical development. In order to identify factors that mediate repetitive behavior development, it is necessary to characterize the expression of these behaviors from an early age. Extending previous findings, we characterized further the ontogeny of stereotyped motor behavior both in terms of frequency and temporal organization in deer mice. A three group trajectory model provided a good fit to the frequencies of stereotyped behavior across eight developmental time points. Group based trajectory analysis using a measure of temporal organization of stereotyped behavior also resulted in a three group solution. Additionally, as the frequency of stereotyped behavior increased with age, the temporal distribution of stereotyped responses became increasingly regular or organized indicating a strong association between these measures. Classification tree and principal components analysis showed that accurate classification of trajectory group could be done with fewer observations. This ability to identify trajectory group membership earlier in development allows for examination of a wide range of variables, both experiential and biological, to determine their impact on altering the expected trajectory of repetitive behavior across development. Such studies would have important implications for treatment efforts in neurodevelopmental disorders such as autism.

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Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

Cited by 206 publications

References 56 publications

ASD Validity

ASD Validity

Addiction and Autism: A Remarkable Comorbidity?

Repetitive motor behavior: Further characterization of development and temporal dynamics

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