Based on the daily precipitation data of 27 meteorological stations from 1960 to 2009 in the Huaihe River Basin, spatio-temporal trend and statistical distribution of extreme precipitation events in this area are analyzed. Annual maximum series (AM) and peak over threshold series (POT) are selected to simulate the probability distribution of extreme precipitation. The results show that positive trend of annual maximum precipitation is detected at most of used stations, only a small number of stations are found to depict a negative trend during the past five decades, and none of the positive or negative trend is significant. The maximum precipitation event almost occurred in the flooding period during the 1960s and 1970s. By the L-moments method, the parameters of three extreme distributions, i.e., Generalized extreme value distribution (GEV), Generalized Pareto distribution (GP) and Gamma distribution are estimated. From the results of goodness of fit test and Kolmogorov-Smirnov (K-S) test, AM series can be better fitted by GEV model and POT series can be better fitted by GP model. By the comparison of the precipitation amounts under different return levels, it can be found that the values obtained from POT series are a little larger than the values from AM series, and they can better simulate the observed values in the Huaihe River Basin.