Changes in voiding behavior in a mouse model of Alzheimer’s disease

Abstract

Besides cognitive decline and behavioral alteration, urinary incontinence often occurs in patients suffering from Alzheimer’s disease (AD). To determine whether the transgenic mouse model of AD, APP/PS1 (APPSL/PS1M146L) mouse, shows alteration of the urinary bladder function and anxiety, as for patients with AD, we examined the urinary marking behavior in relation to affective behavior. At 18 months of age voiding behavior of APP/PS1 and wild type (WT) mice was assessed by using a modified filter paper assay in combination with video tracing, with the cage divided into a center and corner zones. Anxiety-related behavior and locomotion were respectively tested in an elevated zero maze (EZM) and an open field (OF). The APP/PS1 mice urinated more in the center zone than the WT mice. The total volume of markings was significantly lower in the APP/PS1 mice. In both groups, the average volume of a marking in the corner zone was larger than in the center zone. In the EZM, the APP/PS1 mice spent less time in the open arms of the arena, considered as anxiogenic zones, than the WT mice. During the OF task, the APP/PS1 mice covered a longer distance than the WT mice. These findings show that the APP/PS1 mice have a different voiding behavior compared to the WT mice, i.e., urinating with small volumes and voiding in the center of the cage, and suggest that increased locomotor activity and anxiety-related behaviors are factors in the change in voiding pattern in the APP/PS1 mouse.

Tat-haFGF 14–154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway

“…Body weights of mice had no significant change in the whole experimental period (Figure S2B). It is reported that APP/PS1 mice fail to construct nests 27 and display an increased locomotor activity compared with wild-type mice 28, 29. The nesting scores of the PS1/APP mice improved significantly with both T600 and L + T600 treatments (p < 0.01 for T600, p < 0.01 for L + T600; Figures S3A and S3B).…”

Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function

“…A recent study showed an altered voiding behavior in a transgenic mouse model of AD [52]. The authors explained that the reason of voiding alterations in the APP/presenilin 1 of mice could be because of the changes in related to anxiety and general locomotor behavior, specific of AD.…”

Neurourological Application of Neurogenesis and Inflammation and Pain Mechanisms of Rocuronium Bromide

“…In patients with cerebral infarction, retention of urine caused by areflexic bladder, urinary urgency, or urinary frequency caused by detrusor hyperreflexia occurs frequently. However, there is a shortage of satisfactory treatments to control and improve neurogenic bladder induced by such neurological diseases [3,4]. …”