Changes of omentin-1 and chemerin during 4 weeks of lifestyle intervention and 1 year follow-up in children with obesity

Siegrist, Monika; Heitkamp, Melanie; Braun, Isabell; Vogg, Nicolas; Haller, Bernhard; Langhof, Helmut; Köenig, Wolfgang; Halle, Martin

doi:10.1016/j.clnu.2021.09.042

“…In another study, overweight/obese children also displayed improved omentin levels after undergoing a short-term (four-week) standardized lifestyle intervention program. 46 These reversible changes suggest that omentin is also a promising serological marker for monitoring the outcome of obesity interventions. 47 …”

Section: Discussionmentioning

confidence: 99%

“…In another study, overweight/obese children also displayed improved omentin levels after undergoing a short-term (four-week) standardized lifestyle intervention program. 46 These reversible changes suggest that omentin is also a promising serological marker for monitoring the outcome of obesity interventions. 47 Common problems faced by previous clinical studies on omentin in children and adolescents include: (1) a small sample size; (2) most of the recruited participants were obese patients; (3) relatively few studies on Han Chinese populations.…”

mentioning

confidence: 99%

Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China

Sun¹,

Li²,

Tian³

et al. 2022

DMSO

View full text Add to dashboard Cite

We investigated the association of omentin with metabolic syndrome (MetS), MetS components, and obesity in adolescents. Methods: A total of 742 middle-school students from Liaoyang City were enrolled in this cross-sectional study using the stratified cluster sampling method. Clinical information and blood samples were collected, and serum omentin levels were measured using enzyme-linked immunosorbent assay. Results: Mean plasma omentin levels were lower in male than in female participants (88.25 (interquartile range 63.02-133.61) vs 99.46 (interquartile range 69.08-188.35) ng/L, P = 0.004). The participants were divided into four groups according to the quartile (Q) values of omentin from low to high. With increasing omentin levels from Q1 to Q4, the age of adolescents and the proportion of males gradually increased (P < 0.05), whereas the body mass index (BMI) (P < 0.05) and prevalence of MetS (P > 0.05) tended to decrease. Omentin levels were significantly and negatively correlated with waist circumference and BMI (correlation coefficients of ˗0.099 and ˗0.115, respectively). Regression analysis showed that omentin level was independently associated with the risk of MetS (Odds ratio, OR = 0.639, 95% confidence interval, CI (0.432, 0.945)), which was attributed to the association with central obesity (OR = 0.775, 95% CI (0.605, 0.993)) among MetS components. Increased omentin levels also indicated a reduced risk of obesity (OR = 0.700, 95% CI (0.563, 0.870)). Conclusion:Omentin is an independent predictor of MetS and obesity among adolescents in northeast China.

show abstract

“…In studies with children, an increase in omentin-1 levels has also been shown after a hypocaloric diet. Siegrist et al (25) reported effects of a short-term weight reduction (1 month) on BMI and omentin-1 levels in children. The same results were observed by Zhang et al (26) in a long-term lifestyle intervention during 6 months in obese children (aged 7-18 years) with metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial with Two Hypocaloric Diets with Different Lipid Profiles and Effects on Serum Omentin-1 Levels in Obese Subjects

Luis

¹

,

Izaola

²

,

Primo

³

et al. 2022

Disease Markers

2

0

View full text Add to dashboard Cite

Background. The effects of weight loss therapies on omentin-1 levels have been unclear, showing both elevations and decreases in circulating levels. The role of dietary fat might have an important role. The aim of our investigation was to evaluate the influence of weight decrease on omentin-1 levels after two different high-fat hypocaloric diets. Methods. 319 Caucasian obese subjects were randomly allocated during 12 weeks (Diet M (high monounsaturated fat diet) vs. Diet P (high polyunsaturated fat diet)). The mean age was 47.2 ± 5.0 years (range: 26-64), and the mean body mass index (BMI) was 37.9 ± 4.1 kg/m2 (range: 30.6-39.8). Sex distribution was 237 females (74.7%) and 72 males (25.3%). Anthropometric and biochemical parameters were evaluated at basal and after both diets. SPSS 23.0 has been used to realize univariant and multivariant statistical analysis. Results. After both diets, BMI, weight, fat mass, waist circumference, systolic blood, LDL-cholesterol, insulin levels, and HOMA-IR decreased in a statistical way from basal values. These improvements were similar in both diets. After Diet P, omentin-1 levels increase ( 21.2 ± 9.1 ng/ml: P = 0.02 ), and after Diet M, this adipokine increases ( 47.1 ± 11.2 ng/ml: P = 0.02 ), too. The increase of omentin-1 with Diet M was statistically significantly higher than that after Diet P ( P = 0.01 ). A multiple regression analyses adjusted by age and sex reported a statistical relation between BMI (kg/m2) and insulin (UI/L) with omentin-1 levels. Conclusions. Our study demonstrated a significant improvement on serum omentin-1 levels after weight loss secondary to both diets; in contrast, omentin-1 improvement was higher with Diet M than with Diet P.

show abstract

“…The most studied adipokines are successfully included in the design of clinical trials as predictive markers of various obesity-related diseases, as well as endpoints in studies of the efficacy of preparations. Numerous studies demonstrate the association of physical activity, lifestyle correction, and weight loss with different adipokine levels [ 124 , 125 , 126 ]. However, in prospective population-based study of 6.502 participants free of CVD at baseline, no association of adiponectin and leptin levels with cardiovascular outcomes was revealed after a mean follow-up time of 11.4 years [ 127 ].…”

Section: Adipokines In Clinical Trialsmentioning

confidence: 99%

The Role of Adipokines in Inflammatory Mechanisms of Obesity

Kirichenko

¹

,

Markina

²

,

Bogatyreva

³

et al. 2022

IJMS

View full text Add to dashboard Cite

Adipokines are currently widely studied cellular signaling proteins produced by adipose tissue and involved in various processes, including inflammation; energy and appetite modulation; lipid and glucose metabolism; insulin sensitivity; endothelial cell functioning; angiogenesis; the regulation of blood pressure; and hemostasis. The current review attempted to highlight the key functions of adipokines in the inflammatory mechanisms of obesity, its complications, and its associated diseases. An extensive search for materials on the role of adipokines in the pathogenesis of obesity was conducted online using the PubMed and Scopus databases until October 2022.

show abstract

Changes of omentin-1 and chemerin during 4 weeks of lifestyle intervention and 1 year follow-up in children with obesity

Cited by 13 publications

References 37 publications

Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China

Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China

A Randomized Trial with Two Hypocaloric Diets with Different Lipid Profiles and Effects on Serum Omentin-1 Levels in Obese Subjects

The Role of Adipokines in Inflammatory Mechanisms of Obesity

Contact Info

Product

Resources

About