Changing role of fine-needle aspiration in the evaluation of pediatric masses

Howell, Lydia Pleotis

doi:10.1002/1097-0339(200101)24:1<65::aid-dc1011>3.0.co;2-t

Cited by 19 publications

(13 citation statements)

References 38 publications

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“…FNAC of the lymphadenopathy is well accepted as a diagnostic procedure in the adult population, hence, FNAC in the pediatric population is rapidly gaining acceptance as pediatricians build confidence in this diagnostic test (Howell, 2001;Amy et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytopathology of Pediatric Lympha denopathy among Sudanese Children

Ahmed

Elmubasher²,

Salih³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Pediatric lymphadenopathy is a challenging medical situation for the child patient, the parents, and the physician. Although the bulk of masses will be benign the fear of malignancy is omnipresent. Therefore, the objective of this study was to identify the common cytopathological patterns of lymphadenopathy among Sudanese children. Methods: One hundred pediatric patients presenting with peripheral lymphadenopathy were included in the study, their ages ranging from 2 to 14 years, with a mean age of 7 years. Demographic characteristics, clinical manifestations and FNA materials were prospectively obtained. Results: FNA was performed in 100 cases (100%). There were no technical complications. All cases confirmed adequacy of specimen. Overall, FNA demonstrated 90 (90%) benign lesions and 10 (10%) malignant diagnosis. The benign lesions were reactive lymphoid hyperplasia (n=64), followed by benign granulomatous disease (n=26). Of the 10 cases diagnosed with malignancy, 7 (7%) were cases of non-Hodgkin`s lymphoma and the remaining 3 (3%) were Hodgkin's lymphomas. Conclusion: Pediatric lymphadenopathy is common in Sudan. CLA is the common frequent site. Lymphoma represents a major challenge in this setting.

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Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytopathology of Pediatric Lympha denopathy among Sudanese Children

Ahmed

Elmubasher²,

Salih³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…[5][6][7][8][9][10] As reported by Howell, the use of FNA for superficial palpable lesions is gaining momentum in the pediatric patient population. 6 To date, research detailing application of FNA to lesions of the head and neck in pediatric populations and the number of cases evaluated are limited. Moreover, some studies have limited their focus to features of malignant lesions, such as small round cell neoplasms or salivary gland lesions.…”

mentioning

confidence: 93%

Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Dutta¹,

Awasthi²,

Agarwal³

et al. 2010

PLMI

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Background: Fine needle aspiration (FNA) biopsy is a well accepted diagnostic procedure and considered to be a valuable test for initial assessment of head and neck swellings in adults. The technique has gained popularity in the pediatric population over the last decade, with varying degrees of acceptance rates, accuracy, and results among pathologists. Objective: This study was performed to evaluate the utility of aspiration cytology as a first-line diagnostic tool in palpable head and neck masses in children, taking into account the diversity of lesions observed in this subset of the population. Cytologic analysis was correlated with histologic results for evaluating diagnostic accuracy wherever possible. The applicability of FNA biopsy in diagnosing pediatric malignant lesions was also evaluated. Methods: This retrospective study conducted from January 2008 to December 2009 screened all pediatric cases referred to the departments of pathology at two tertiary care hospitals in India. Data from a total of 662 children aged 0-15 years presenting with head and neck masses who underwent FNA biopsy were collected. Cytologic results were interpreted and analyzed according to anatomic site. The lesions were then categorized into inflammatory, infective, and neoplastic. Results: Of the 662 lesions, 23 cases were excluded due to inadequate material, thus the data for 639 cases were finally evaluated. Lymph node lesions predominated, accounting for 570 cases (89.2%), of which 412 (72%) cases were diagnosed as reactive and 91 (16%) cases as tubercular lymphadenitis. Other lesions aspirated were thyroid (18 cases, 2.8%), salivary gland (12 cases, 1.8%), and miscellaneous surface lumps (39 cases, 6.1%). Of all the cases, 628 (98.27%) were reported as benign and 11 (1.67%) as malignant. The positive predictive value of cytologic analysis in diagnosing malignancy was 100%, although exact typing of lesions was possible only on histopathologic examination. Conclusion: FNA biopsy is a sensitive and minimally invasive first-line investigation in the diagnosis of head and neck masses in children. It is highly accurate in isolating and determining potentially neoplastic lesions, thus guiding the way for cases which truly require excision biopsy or other second-line investigations.

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“…1 FNAB is well established as the diagnostic procedure of choice for superficial mass lesions. [2][3][4] However, few data are available on its routine use in paediatric practice, especially in resourcelimited settings.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7] In experienced hands, a high level of diagnostic accuracy is possible, averting the need for a formal biopsy and all its associated risks. 8 Apart from providing a cytological diagnosis, FNAB also provides tissue for ancillary tests, such as microbiological cultures, flow cytometry, cytogenetics, electron microscopy and polymerase chain reaction (PCR).…”

Section: Introductionmentioning

confidence: 99%