Channa striatus cream down-regulates tumour necrosis factor (TNF)-alpha gene expression and alleviates chronic-like dermatitis in mouse model

Isa, Irma Izani Mohamad; Bakar, Suhaili Abu; Tohid, Siti Farah Md; Jais, Abdul Manan Mat

doi:10.1016/j.jep.2016.10.033

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Therefore, the aqueous extract of C. striatus could inhibit monocyte infiltration and fibroblast proliferation; these may potentially prevent atherosclerosis development. respectively; these effects were comparable to 1% hydrocortisone administration of these doses of C. striatus cream also down-regulated TNF- gene expression level to 34, 54, and 112-fold respectively, with significant reduction as compared to TPA (negative control) alone [18]. Based on the studies highlighted, it could be deduced that the anti-inflammatory effects of C. striatus is attributed to the inhibition of the pro-inflammatory cytokine, TNF- production.…”

Section: Anti-inflammatory Propertymentioning

confidence: 57%

“…C. striatus has been demonstrated to exert several pharmacological activities [11,12], majorly attributed to its high content of essential amino acids and fatty acids [13,14]. Previous studies have reported C. striatus to have hypoglycemic [15], antioxidant [16], anti-inflammatory [11,[17][18][19], antinociceptive [12,[20][21][22], anti-bacterial [23,24], wound healing [25][26][27][28][29], and anti-ulcer [8,30] properties. Therefore, this review aims to provide an overview of the pharmacological properties of C. striatus related to diabetes and cardiovascular complications.…”

Section: Introductionmentioning

confidence: 99%

“…All three doses of C. striatus based cream significantly reduced myeloperoxidase (MPO) activity to 3.7%, 3.24%, and 2.7%, respectively, compared to vehicle control. MPO is a pro-inflammatory enzyme released by activated neutrophils and macrophages (markers of polymorphonuclears accumulation)[17].Another in-vivo study by Isa et al reported the anti-inflammatory effect of C. striatus cream on 12-tetradecanoylphorbol-13-acetate (TPA)-induced chronic dermatitis in mice[18]. Administration of C. striatus cream at doses 1%, 5%, and 10% reduced mouse-ear thickness to 0.547  0.025 mm (19.4%), 0.556  0.018 mm (18.1%), 0.489  0.015 mm (28%)…”

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confidence: 99%

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Review of Pharmacological Properties of <em>Channa Striatus</em> (Haruan) In Diabetes and Cardiovascular Complications

Azemi¹,

Mustapha²,

Mohammed³

et al. 2021

Preprint

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Diabetes mellitus remains a major risk factor for developing cardiovascular diseases, resulting in increased morbidity and mortality associated with cardiovascular complications. Given the burden of diabetes-related cardiovascular complications, there is a need to identify strategies, safe and effective therapeutic agents that could effectively prevent and control diabetes. Presently, many patients living with diabetes depends on traditional medicines as an alternative cure. Channa striatus (Haruan) is a freshwater fish traditionally used to treat wounds, inflammations, and pains. Several pharmacological investigations have supported the folkloric claims of C. striatus extracts, including hypoglycemic, hypolipidemic, antioxidant, anti-inflammatory, and pro-platelet aggregation activities. The therapeutic potentials of C. striatus were demonstrated to be associated with the presence of high content essential amino acids and good fatty acids known to improve cell growth and facilitate wound healing. Therefore, C. striatus bioactive compounds have great potentials to serve as lead candidates in developing novel therapeutic agents for the management of diabetes and related cardiovascular diseases. This review aims to provide a comprehensive overview of the pharmacological properties and therapeutic potentials of C. striatus for the management of diabetes and associated cardiovascular complications.

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Section: Anti-inflammatory Propertymentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Review of Pharmacological Properties of <em>Channa Striatus</em> (Haruan) In Diabetes and Cardiovascular Complications

Azemi¹,

Mustapha²,

Mohammed³

et al. 2021

Preprint

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show abstract

“…This can be seen from the results of a study conducted by Adam et al, which stated that the application of snakehead fish extract significantly reduced the expression of TNF-α [20]. The results of the study by Isa et al concluded that snakehead fish is an effective topical anti-inflammatory agent in a mouse model with chronic inflammation [21]. It is still largely unknown which bioactive compounds from snakehead fish are involved in the anti-inflammatory mechanism.…”

Section: Discussionmentioning

confidence: 99%

COMBINED CHIP APPLICATION'S EFFECT OF CLINICAL PARAMETERS AND TNF-α EXPRESSIONS

JASMANIAR,

NASUTION,

ILYAS

et al. 2024

Int J App Pharm

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Objective: Scaling root planing is the main mechanical treatment to remove local deposits. Supportive local and systemic antimicrobial therapy is used to eliminate or reduce the number of pathogenic bacteria. The chip application of the combination of snakehead fish extract and betel leaf can change the clinical parameters for the better and increase the expression of TNF-α as a pro-inflammatory. To see the effect of the application of a chip combination of snakehead fish extract and betel leaf in male Wistar rats induced by periodontitis as a support for initial therapy on clinical parameters and expression of TNF-α. Methods: Laboratory experimental study with a posttest control group design in which 24 male Wistar rats induced periodontitis were in four treatment groups (2.5%, 5%, 10% snakehead fish extract and placebo). Examination of clinical parameters and expression of TNF-α was carried out on day 0, day 3 and day 7. Data were analyzed by the Mann-Whitney test. Results: The results showed that the clinical parameters; gingival index, pocket depth and attachment level looked better on the 7th day after treatment with statistically significant results (p≤0.05) and the highest anti-inflammatory TNF-α expression occurred at a concentration of 5%. Conclusion: The application of a chip combination of snakehead fish extract and betel leaf as a support for initial therapy is effective in reducing the gingival index pocket depth and increasing the level of attachment, which is statistically significant, but there is no significant difference in TNF-α expression.

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“…6 Some researchers have studied about the benefits of snakehead fish for reducing inflammation. Local people believed that snakehead fish reduces pain and use it mostly for treating mothers after delivery and any post-operative pain, 7 wound healing, 5,[8][9] anti-eczema, 10 and platelet aggregation 2 are some wellknown pharmacological properties of snakehead fish are demonstrated till now. Glycine is one of the amino acids which have the highest content in SFP.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Formulation of Snakehead Fish (Ophiocephalus striatus) Powder and Toxicity Study in Zebrafish (Danio rerio) Model

et al. 2019

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A B S T R A C TBackground: Snakehead fish (Ophiocephalus striatus) is a freshwater fish that is utilized as anti-inflammatory and anticancer drug. The aim of this study was to determine the toxicity effect of snakehead fish powder (SFP), formulate it into liposome and in vitro study using sensitive and resistant breast cancer cells. Methods: Dried powder of snakehead fish was made using the atomizer then made a test solution which was divided into 7 treatment groups in different concentrations. They were exposed to zebrafish embryos then observed for 72 h post fertilization (hpf). After acquiring the half maximal inhibitory concentration (IC50) and lethal concentration (LC50) of SFP, these concentrations were used to formulate SFP into liposome by extrusion method. SFP-liposomes were characterized and stable tested. Afterwards, SFP-liposomes were evaluated in vitro using sensitive and resistant breast cancer cells. Results: The maximum allowed toxicant concentration of SFP was 0.0543 mg/mL meaning slight toxic symptoms, IC50 = 0.0945 mg/mL showing the growth inhibition of zebrafish embryos, and LC50 = 0.1549 mg/mL meaning very toxic category that has killed zebrafish embryos. The characterization results showed that size of SFP-liposome were 121 nm ± 0.29, polydispersity index 0.06 ± 0.02, zeta-potential -10.15 mV ± 0.36 and % entrapment efficiency (EE) 85.75% ± 2.24. Six weeks of stability study showed that size profile was stable at 25°C and 37°C. Moreover, SFP-liposomes inhibited breast cancer cell proliferation when evaluated with 4T1 and MDA-MB231-sensitive and resistant cells. Conclusion: SFP has bioactive compounds based on toxicity effect and can be formulated into liposome as a promising nanonutraceutical formulation.

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Channa striatus cream down-regulates tumour necrosis factor (TNF)-alpha gene expression and alleviates chronic-like dermatitis in mouse model

Abstract: Haruan is an effective topical anti-inflammatory agent in this mouse model of chronic-like dermatitis, thus suggesting its potential as a non-steroidal treatment option for chronic inflammatory dermatoses.

Cited by 8 publications

References 35 publications

Review of Pharmacological Properties of <em>Channa Striatus</em> (Haruan) In Diabetes and Cardiovascular Complications

Review of Pharmacological Properties of <em>Channa Striatus</em> (Haruan) In Diabetes and Cardiovascular Complications

COMBINED CHIP APPLICATION'S EFFECT OF CLINICAL PARAMETERS AND TNF-α EXPRESSIONS

Liposomal Formulation of Snakehead Fish (Ophiocephalus striatus) Powder and Toxicity Study in Zebrafish (Danio rerio) Model

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