Chapter 2 Vacuolation in the young

Baintner, K.

doi:10.1016/s1877-1823(09)70118-3

Cited by 22 publications

(27 citation statements)

References 247 publications

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“…Gut closure around day 2 was found to be a transient stage of the intestine initiated in the proximal region and moving aborally to the distal region. Most of these observations are nicely supported by Baintner (2002) and Trahair and Sangild (2002).…”

Section: Discussionsupporting

confidence: 53%

The early postnatal pattern of vesicle formation in different regions of the porcine small intestine

Elbrønd¹,

Weström

2007

Livestock Science

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Section: Discussionsupporting

confidence: 53%

The early postnatal pattern of vesicle formation in different regions of the porcine small intestine

Elbrønd¹,

Weström

2007

Livestock Science

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“…Development of the GIT in utero is characterised by extensive structural and functional changes in the intestinal epithelium (64,65) . However, there are marked differences in the stages of intestinal maturation in various mammalian species at birth.…”

Section: The Most Frequently Used Animal Modelsmentioning

confidence: 99%

Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

Guilloteau

Zabielski²,

Hammon³

et al. 2010

Nutr. Res. Rev.

271

222

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The consequences of early-life nutritional programming in man and other mammalian species have been studied chiefly at the metabolic level. Very few studies, if any, have been performed in the gastrointestinal tract (GIT) as the target organ, but extensive GIT studies are needed since the GIT plays a key role in nutrient supply and has an impact on functions of the entire organism. The possible deleterious effects of nutritional programming at the metabolic level were discovered following epidemiological studies in human subjects, and confirmed in animal models. Investigating the impact of programming on GIT structure and function would need appropriate animal models due to ethical restrictions in the use of human subjects. The aim of the present review is to discuss the use of pigs as an animal model as a compromise between ethically acceptable animal studies and the requirement of data which can be interpolated to the human situation. In nutritional programming studies, rodents are the most frequently used model for man, but GIT development and digestive function in rodents are considerably different from those in man. In that aspect, the pig GIT is much closer to the human than that of rodents. The swine species is closely comparable with man in many nutritional and digestive aspects, and thus provides ample opportunity to be used in investigations on the consequences of nutritional programming for the GIT. In particular, the 'sow -piglets' dyad could be a useful tool to simulate the 'human mother-infant' dyad in studies which examine short-, middle-and long-term effects and is suggested as the reference model.

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“…The mechanism of absorption of luminally released CCK and gastrin is far from being understood, though an enterocyte transcellular pathway seems quite probable under physiological conditions rather than a paracellular process. In newborns, the canaliculo-vesicular system present in the enterocytes could be an ideal means of a non-specific transport of all large-size molecules, in particular during the first days of life when the so-called 'transport vacuoles' exist (Baintner, 2002). The contents of 'transport vacuoles' are not affected by the lysosomal enzymes, thereby the absorbed molecules retain their biological activity.…”

Section: Molecular Formsmentioning

confidence: 99%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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Chapter 2 Vacuolation in the young

Cited by 22 publications

References 247 publications

The early postnatal pattern of vesicle formation in different regions of the porcine small intestine

The early postnatal pattern of vesicle formation in different regions of the porcine small intestine

Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

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