Chapter 33. Plasma Protein Binding of Drugs

Olson, R. E.; Christ, David D.

doi:10.1016/s0065-7743(08)60472-8

Cited by 265 publications

(129 citation statements)

References 71 publications

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“…Under these experimental conditions, K 2 = 2/3, N= 1.336, φ=0.118 (Olson and Christ, 1996), and J were given using the equation:…”

Section: Resultsmentioning

confidence: 99%

Studies on the Interaction Between Triptolide and Bovine Serum Albumin (Bsa) by Spectroscopic and Molecular Modeling Methods

Wang¹,

Shi²,

Pang³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Triptolide is a major active constituent isolated from Tripterygiumwilfordii Hook F, a Chinese herbal medicine. This study investigated the intermolecular interaction between triptolide and bovine serum albumin (BSA). Materials and Methods:The fluorescence, circular dichroism (CD) and molecular docking methods were used to investigate the intermolecular interaction between triptolide and BSA. The binding constant, the number of binding sites, binding subdomain and the thermodynamic parameters were measured. Results: The results of this experiment revealed that the intrinsic fluorescence of BSA was effectively quenched by triptolide via static quenching. The experimental results of synchronous fluorescence and CD spectra showed that the conformation of BSA was changed in the presence of triptolide. Conclusion: It indicated that triptolide could spontaneously bind on site II (subdomain IIIA) of BSA mainly via hydrogen bonding interactions and Van der Waals force.

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“…Under these experimental conditions, K 2 = 2/3, N= 1.336, φ=0.118 (Olson and Christ, 1996), and J were given using the equation:…”

Section: Resultsmentioning

confidence: 99%

Studies on the Interaction Between Triptolide and Bovine Serum Albumin (Bsa) by Spectroscopic and Molecular Modeling Methods

Wang¹,

Shi²,

Pang³

et al. 2016

Afr J Tradit Complement Altern Med

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“…As is well known, serum albumins are the most abundant proteins in circulatory system, playing the most important physiological role in transportation of numerous exogenous and endogenous ligands, such as drugs in the bloodstream to their target organs. 15 So, it is very meaningful to explore the action mode between K 4 Sm 0.4 La 0.6 (L 4 )Cl 3 ·5H 2 O and bovine serum albumin (BSA), which can provides a theoretical basis for their potential medicinal value.…”

Section: -13mentioning

confidence: 99%

The Co-luminescence Groups of Sm-La-pyridyl Carboxylic Acids and the Binding Characteristics between the Selected Doped Complex and Bovine Serum Albumin

Yang¹,

Tang²,

Tang³

2012

Bulletin of the Korean Chemical Society

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A novel ligand N,N'-(2,6-pyridinedicarbonyl)bis [N-(carboxymethyl)] (L 1 ) was designed and synthesized. Four co-luminescence groups of Sm-La-pyridyl carboxylic acids systems were researched, which areThe results indicated the addition of La(III) could sensitize the luminescence of Sm(III) obviously in a certain range, enhancing emission intensity of Sm-pyridyl carboxylic acids relative to the undoped ones. The optimal mole percentages of La(III) in the mixed ions for L 1 , L 2 , L 3 , L 4 were confirmed to be 0.6, 0.5, 0.3, 0.6, respectively. The mechanism of the fluorescence enhancement effect was discussed in detail. Furthermore, the binding interaction of K 4 Sm 0.4 La 0.6 (L 4 )Cl 3 ·5H 2 O with bovine serum albumin (BSA) have been investigated due to its potential biological activity. The binding site number n was equal to 1.0 and binding constant K a was about 2.5 × 10 5 L·mol −1.

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“…2,3,4 In addition, the role of plasma protein binding has been recognized as an important factor in drug disposition and efficacy. 5 In this context, drug binding to TP is a key process, which is involved in phenomena such as modulation of drugs solubility in plasma, toxicity, in vivo half-life, etc. 6 Concerning serum albumins, they are major carriers of small organic molecules, which bind primarily to two high-affinity sites (called site I or warfarin binding site and site II or indole-benzodiazepine binding site), with typical association constants in the range of 10 4 -10 6 M -1 .…”

Section: Introductionmentioning

confidence: 99%

Triplet Excited States as a Source of Relevant (Bio)Chemical Information

Jiménez

Miranda

2015

CTMC

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Triplet excited states exhibit strongly medium-dependent properties, which turns them into valuable tools to probe the microenvironments existing in protein binding Finally, protein encapsulation can also modify the photoreactivity of the guest. This is illustrated by presenting an example of retarded photooxidation. 2 Graphical abstractKeywords: 1-acid glycoproteins, drug, laser flash photolysis, serum albumins, protein binding, transient absorption spectroscopy.

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Chapter 33. Plasma Protein Binding of Drugs

Cited by 265 publications

References 71 publications

Studies on the Interaction Between Triptolide and Bovine Serum Albumin (Bsa) by Spectroscopic and Molecular Modeling Methods

Studies on the Interaction Between Triptolide and Bovine Serum Albumin (Bsa) by Spectroscopic and Molecular Modeling Methods

The Co-luminescence Groups of Sm-La-pyridyl Carboxylic Acids and the Binding Characteristics between the Selected Doped Complex and Bovine Serum Albumin

Triplet Excited States as a Source of Relevant (Bio)Chemical Information

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