Characterisation of Polycaprolactone Scaffolds Made by Melt Electrospinning Writing for Pelvic Organ Prolapse Correction- a Pilot Study

Rynkevic, Rita; Silva, Elisabete; Martins, Pedro S.; Mascarenhas, Teresa; Alves, Jorge Lino; Fernandes, António Augusto

doi:10.2139/ssrn.4036396

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…The existing literature states that the mesh thickness should fall within the range of 0.08 mm–0.24 mm (Rynkevic et al. , 2022; Cunha, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…The existing literature states that the mesh thickness should fall within the range of 0.08 mm-0.24 mm (Rynkevic et al, 2022;Cunha, 2020). Additionally, the mesh pores should have a diameter of approximately 2.00 mm to promote cell growth (Cunha et al, 2021).…”

Section: Mesh Prototypingmentioning

confidence: 99%

“…The mesh is made up of three knitted monofilaments, each with a diameter of 0.08 mm. The pores of the mesh are approximately 2.00 mm in size (Rynkevic et al, 2022). To help visualise the mesh, Figure 2 provides an SEM (Scanning Electron Microscope) image.…”

Section: Engineering Computationsmentioning

confidence: 99%

“…Biodegradable meshes offer advantages due to their inherent biocompatibility and biomechanical properties. Rapid prototyping in additive manufacturing and 3D printing inspired the development of customised medical devices, such as biodegradable meshes using melt electrowriting (MEW) with technical-grade and medical-grade polycaprolactone (PCL) (Cunha et al, 2022;Rynkevic et al, 2022). Ren et al, highlights the potential of biodegradable meshes for POP treatment (Ren et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Rapid prototyping in additive manufacturing and 3D printing inspired the development of customised medical devices, such as biodegradable meshes using melt electrowriting (MEW) with technical-grade and medical-grade polycaprolactone (PCL) (Cunha et al. , 2022; Rynkevic et al. , 2022).…”

Section: Introductionmentioning

confidence: 99%

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3D printing and development of computational models of biodegradable meshes for pelvic organ prolapse

Vaz,

Silva,

Parente

et al. 2024

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PurposeDevelop biodegradable meshes as a novel solution to address issues associated with using synthetic meshes for POP repair.Design/methodology/approachComputational models were created with variations in the pore geometry, pore size, filament thickness, and inclusion of filaments around specific mesh regions. Subsequently, one of the meshes was 3D printed to validate the results obtained from the simulations. Following this, a uniaxial tensile test was carried out on the vaginal tissue of a sow to compare with the simulations, to identify meshes that displayed behaviour akin to vaginal tissue. Finally, the most promising outcomes were compared with those of the uterosacral ligament and a commercially available mesh.FindingsFollowing a comprehensive analysis of the results, the mesh that most accurately replicates the behaviour of the vaginal tissue showcases a smaller pore diameter (1.50 mm), filaments in specific areas of the mesh, and variable filament thickness across the mesh. Nevertheless, upon comparing the outcomes with those of the uterosacral, the meshes do not exhibit similar behaviour to the ligament. Finally, the commercially available mesh does not represent the behaviour of both the vaginal tissue and the uterosacral ligament and in this sense may not be the best treatment option for POP repair.Originality/valueTheir biocompatibility and biomechanical properties make them a potential solution to the disadvantages of synthetic meshes. Personalized/customized meshes could be part of the future of surgical POP repair.

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“…The existing literature states that the mesh thickness should fall within the range of 0.08 mm–0.24 mm (Rynkevic et al. , 2022; Cunha, 2020).…”

Section: Methodsmentioning

confidence: 99%

Section: Mesh Prototypingmentioning

confidence: 99%

Section: Engineering Computationsmentioning

confidence: 99%