Characterisation of the glass transition of HPMC using modulated temperature differential scanning calorimetry

McPhillips, H; Craig, Duncan Q.M.; Royall, Paul G.; Hill, V. L.

doi:10.1016/s0378-5173(98)00407-4

Cited by 93 publications

(50 citation statements)

References 12 publications

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“…S1 supplementary information). These results are in agreement with those reported in the literature (31)(32)(33). Endothermic peaks representing water evaporation appeared in approximately the same regions for the HPMC films, and eventually disappeared with increasing drying times (Fig.…”

Section: Thermal Behavior Of the Polymer During Dryingsupporting

confidence: 83%

Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films

2017

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Abstract.The process of drying thin polymer films is an important operation that influences the film structure and solid state, and the stability of the product. The purpose of this work was to study and model the drying kinetics of multicomponent films based on two polymers: hydroxypropyl methylcellulose (HPMC, amorphous) and polyvinyl alcohol (PVA, semicrystalline). The isothermal drying kinetics of the films at different temperatures (40, 60, and 80°C) were studied using thermo-gravimetric analysis (TGA) and convection oven methods. Solid-state characterization tools used in the study included polarization and hotstage microscopy, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). The drying kinetics of HPMC and PVA films in the TGA apparatus and convection oven were comparable. The three-parameter (W max , τ, n) Hill equation successfully modeled the experimental drying kinetics. The time factor τ in the Hill equation nicely explained two drying phases in the films. Solid-state phase changes occurring in the films during dehydration had a bearing on the drying kinetics and mechanisms. TGA can be used as a simple tool to determine the end points in drying processes using ovens or tunnels. The three-parameter Hill equation explained the drying kinetics and diffusion mechanisms of the solvent through the polymer films for the first time. This study advances our understanding of film drying, in particular for pharmaceutically relevant thin films.

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Section: Thermal Behavior Of the Polymer During Dryingsupporting

confidence: 83%

Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films

2017

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“…Therefore, nonhermatically sealed pans with a pinhole in the lid were used; for the non-anhydrous samples, these pans showed a continuous loss of water. This experimental protocol is in agreement with studies done by McPhillips et al 16,17 The sample size used was between 0.015 and 0.020 g; in this range, no in¯uence of sample size was observed.…”

Section: Differential Scanning Calorimetrysupporting

confidence: 77%

Characterization of the thermal properties of microcrystalline cellulose by modulated temperature differential scanning calorimetry

Picker

Hoag

2002

Journal of Pharmaceutical Sciences

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“…4) is not due to degradation, but more likely due to stabilization of the foam and thermal softening. The DMTA experiments indicated a softening of the HPMC foam around 155°C, in accordance with DSC data reported by (Meena et al 2014) (McPhillips et al 1999). …”

Section: Water Losssupporting

confidence: 91%

Foaming behavior of water-soluble cellulose derivatives: hydroxypropyl methylcellulose and ethyl hydroxyethyl cellulose

Karlsson

Schuster²,

Stading

et al. 2015

Cellulose

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Hydroxypropyl methylcellulose and ethyl hydroxyethyl cellulose could be interesting candidates for production of lightweight, foamed packaging material originating from non-fossil, renewable resources. The foaming ability of nine different grades of the two cellulose derivatives, using water as the blowing agent, was investigated using a hot-mold process. The foaming process was studied by evaluating the water loss during the heating, both in a realtime experiment and by thermal gravimetric analysis. Further, the development of the rheological properties of the derivative-water mixtures during a simulated foaming process was assessed using dynamical mechanical thermal analysis and viscosity measurements. Five of the studied derivatives showed promising properties for hot-mold foaming and the final foams were characterized with regard to their apparent density. It was concluded that the foamability of these systems seems to require a rather careful tailoring of the viscoelastic properties in relation to the water content in order to ensure that a network structure is built up and expanded during the water evaporation.

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Characterisation of the glass transition of HPMC using modulated temperature differential scanning calorimetry

Cited by 93 publications

References 12 publications

Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films

Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films

Characterization of the thermal properties of microcrystalline cellulose by modulated temperature differential scanning calorimetry

Foaming behavior of water-soluble cellulose derivatives: hydroxypropyl methylcellulose and ethyl hydroxyethyl cellulose

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