Characteristics and outcomes of overlap myositis: a comparative multigroup cohort study in adults from the MyoCite cohort

Naveen, R; Rathore, Upendra; Agarwal, Vikas; Gupta, Latika

doi:10.1007/s00296-020-04779-y

Cited by 15 publications

(17 citation statements)

References 35 publications

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“…The MyoCite cohort has detailed clinical and biorepository archives as previously detailed [6,[15][16][17][18]. Patient demographics (age, gender), baseline characteristics, such as myositis subtype, and myositis-specific and -associated antibodies (line immunoassay, Lubeck, Germany) were obtained from the archives.…”

Section: Data Retrievalmentioning

confidence: 99%

Validation of two simple patient-centered outcome measures for virtual monitoring of patients with idiopathic inflammatory myositis

et al. 2021

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Section: Data Retrievalmentioning

confidence: 99%

Validation of two simple patient-centered outcome measures for virtual monitoring of patients with idiopathic inflammatory myositis

et al. 2021

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“…Thus, in the past two decades, most cohort-based studies have been on DM and PM, or the presence of a distinct autoantibody thereby limiting the understanding of OM. However, the prevalence of overlap myositis in inflammatory myopathies varies from 22 to 49% [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Overlap myositis is constituted by myositis occurring in the setting of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), mixed connective tissue disorder (MCTD), rheumatoid arthritis (RA), and Sjögren's syndrome (SS). One of the most frequent overlap myositis is represented by myositis and SSc, comprising 15-42.6% of all the overlap syndrome IIMs [ 6 – 8 ]. On the contrary, muscle disease, or myopathy, in scleroderma has been thought to be a relative bystander in comparison to other organ disease manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with systemic sclerosis and myositis have characteristic genetic features, such as the presence of HLA DRB1∗1104, DQA1∗05 : 01, and DQB1∗03 : 01 in SSc and HLA DRB1∗03 : 01 and DQA1∗05 : 01 in myositis [ 14 – 16 ]. Furthermore, clinical characteristics of patients with ASSD and IIM-SSc overlap patients might be similar [ 6 ]. The presence of mechanic's hand, interstitial lung disease, Raynaud's phenomenon, and myositis is frequently found in both clinical syndromes.…”

Section: Introductionmentioning

confidence: 99%

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Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort

Szabó

Bodoki

Nagy‐Vincze

et al. 2022

BioMed Research International

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Overlap myositis is a distinct subgroup of idiopathic inflammatory myositis (IIM) with various clinical phenotypes. The aim of this study was to determine the clinical, serological, and genetic features of systemic sclerosis (SSc)-IIM overlap patients. It was a retrospective study using clinical database of 39 patients, fulfilling both the criteria of SSc and IIM. 56.4% of the patients had limited cutaneous, 43.6% had diffuse cutaneous SSc, whereas 7.7% of the patients had dermatomyositis and 92.3% polymyositis. The two diseases occurred simultaneously in 58.97%, while 10.26% in myositis and 30.77% in scleroderma were initially diagnosed. The frequencies of organ involvement were interstitial lung disease 71.8%, dysphagia 66.7%, cardiac involvement 41%, pulmonary arterial hypertension (PAH) 30.8%, and renal involvement 12.8%, respectively. The presence of human leukocyte antigen HLA − DRB 1 ∗ 03 and DQA 1 ∗ 051 ∗ 01 alleles were significantly higher in the overlap patients than in healthy controls (82.35% vs. 27.54%; p < 0.0001 and 88.24% vs. 30.16; p < 0.0001 ). Certain clinical parameters, such as fever at diagnosis (41.67% vs. 7.41%, p = 0.0046 ), cardiac involvement (83.33% vs. 22.22%, p = 0.0008 ), subcutaneous calcinosis (41.66 vs. 11.11, p = 0.01146 ), and claw hand deformity (25% vs. 11.11%, p = 0.00016 ) were significantly associated with the presence of PAH. Upon comparison, the overlap patients and anti-Jo-1 positive antisynthetase patients showed similarities in terms of genetic results and major clinical features; however, SSc-IIM overlap patients could be distinguished with higher erythrocyte sedimentation rate (ESR) level, more frequent presence of Raynaud’s phenomenon ( p < 0.0001 ; OR: 20.00), dysphagia ( p < 0.0001 ; OR: 15.63), and infrequent livedo reticularis ( p < 0.01 ; OR: 0.11). SSc-IIM overlap myositis is a unique group within IIM-s possessing characteristic clinical features.

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“…Therefore, AMA testing owing to its wide availability and reasonable cost may help to identify and correct previously misdiagnosed cases following up with gastroenterology and cardiology, alongside difficult to treat autoantibody negative IIM which are confused with muscle dystrophies but may respond to immunosuppressants 5,11‐13 . Further, Indian patients with IIM are known to exhibit distinct clinical‐phenotypic features 14‐17 . Current literature on AMA‐positive IIM is limited to short case series, and amounts to a heterogeneous group, with varied clinical features 5‐8 .…”

Section: Introductionmentioning

confidence: 99%

Anti‐mitochondrial antibodies in Indian patients with idiopathic inflammatory myopathies

et al. 2022

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Characteristics and outcomes of overlap myositis: a comparative multigroup cohort study in adults from the MyoCite cohort

Cited by 15 publications

References 35 publications

Validation of two simple patient-centered outcome measures for virtual monitoring of patients with idiopathic inflammatory myositis

Validation of two simple patient-centered outcome measures for virtual monitoring of patients with idiopathic inflammatory myositis

Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort

Anti‐mitochondrial antibodies in Indian patients with idiopathic inflammatory myopathies

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