Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam

Huy, Tran Thien Tuan; Ushijima, Hiroshi; Quang, Vo Xuan; Ngoc, Trinh Thi Bich; Hayashi, Shigeki; Sata, Tetsutaro; Abe, Kenji

doi:10.1002/jmv.20175

Cited by 32 publications

(41 citation statements)

References 36 publications

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“…So far, our study is one of the largest-scale population studies examining the HBV genotype and having the largest population of determining variations in the core promoter and pre-core regions of HBV-DNA in Vietnamese. In agreement with previous studies (25)(26)(27)(28), our results showed that genotypes B and C were the major genotypes in Vietnamese, and that genotype B was more prevalent than genotype C. In the study no cases with genotype A, D, E, F or G were detected. This is the first study to sub-classify genotype B into subgenotype Ba or Bj in Vietnamese and showed that nearly all cases (99.2%) of genotype B were sub-classified into genotype Ba.…”

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confidence: 93%

“…This is the first study to sub-classify genotype B into subgenotype Ba or Bj in Vietnamese and showed that nearly all cases (99.2%) of genotype B were sub-classified into genotype Ba. Our results corresponded to those of previous studies of native Vietnamese and Vietnamese immigrants from other countries (17,19,(25)(26)(27)(28)(29)(30)(31), but were inconsistent with the report that genotype A was very common in Vietnamese (33). It was reported that genotype C in East Asia was more strongly associated with severe liver disease and risk of HCC than genotype B (12)(13)(14)(15)20,24,35,37,48,49).…”

Section: -------------------------------------------------contrasting

confidence: 82%

“…In contrast to the findings of the above studies in Vietnamese, a study by Song et al reported that genotype A was very commonly observed in HBV-infected Vietnamese patients (98.7%), that the pre-core mutation (G1896A) was not found, and dual core promoter mutations (A1762T/G1764A) were very rare in HCC patients (8%) and were not found in LC patients, CH patients or asymptomatic carriers (ASC) (33). The results reported by Song et al were very surprising, since the results of many other studies in East Asia and some in Vietnam, with only the exception of studies in the Philippines, showed that genotypes B and C were the major HBV genotypes in this region and mutations in the core promoter and pre-core regions were frequently found (8)(9)(10)(12)(13)(14)(15)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(34)(35)(36)(37)(38).…”

Section: Introductionmentioning

confidence: 96%

“…There have not been many studies of HBV genotype in Vietnamese but the data from reported studies showed that genotypes B and C prevailed (19,(25)(26)(27)(28). Most patients in those studies were from Southern Vietnam (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

“…Most patients in those studies were from Southern Vietnam (25)(26)(27). A study of patients in Hanoi in Northern Vietnam showed that genotype B was more prevalent than genotype C; however, the number of patients was quite small (28).…”

Section: Introductionmentioning

confidence: 99%

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Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Truong

Seo²,

Yano³

et al. 2007

Int J Mol Med

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Abstract.Vietnam is one of the countries with a high rate of hepatitis B virus (HBV) infection, but there are only a few reports about relation of HBV genotypes and mutations to clinical course in Northern Vietnam. The characteristics of HBV and its relationship to clinical outcome in patients from Northern Vietnam were analyzed. Serum samples were collected from 183 HBV-infected Vietnamese patients. They were clinically categorized into 4 groups: hepatocellular carcinoma (HCC), liver cirrhosis (LC), chronic hepatitis (CH), and asymptomatic carriers (ASC). HBV serology, ·-fetoprotein, HBV genotypes, HBV-DNA level and mutations in the core promoter and pre-core regions of HBV-DNA were examined. The majority of sera contained HBV genotype B (67.8%) and C (27.9%). The median age was matched between genotype B and C (38.2 vs. 42.9 years). The rates of HBeAg seroconversion and G1896A for genotype B were significantly higher than those for genotype C (P<0.05). Genotype C had a higher HBV-DNA level than genotype B. C1858 was frequent, especially in genotype C (62.7%). The most prevalent genotype in ASC and CH was genotype B. The presence of the mutation A1762T/G1764A correlated with disease progression. The triple mutation T1753C/A1762T/ G1764A was quite common and was more prevalent in LC and HCC than in CH and ASC. In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases.

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Section: -------------------------------------------------supporting

confidence: 93%

Section: -------------------------------------------------contrasting

confidence: 82%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Truong

Seo²,

Yano³

et al. 2007

Int J Mol Med

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Variations in the core promoter/pre‐core region in HBV genotype C in Japanese and Northern Vietnamese patients

Truong

Yano

Seo

et al. 2007

Journal of Medical Virology

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Hepatitis B virus (HBV) subgenotypes Cs (C1)and Ce (C2) are common in East Asia. To investigate the genomic difference of HBV genotype C between two separated regions, 50 subgenotype Cs-infected Vietnamese and 70 subgenotype Ce-infected Japanese patients were enrolled for analysis. The patients were categorized to either a hepatocellular carcinoma group (HCC) or a non-HCC group including liver cirrhosis, chronic hepatitis, and asymptomatic carriers. HBV serology, HBV-DNA level, and variations in core promoter/pre-core region were examined. Phylogenetic analysis based on the full genome sequences and nucleotide sequences partly in the S gene and in the P gene revealed that all Japanese strains (70/70) were subgenotype Ce, and nearly all of the Vietnamese strains (50/51) were subgenotype Cs, excluding one subgenotype C5. C1858 and G1775 were common in the Vietnamese (64% and 40%) but not in the Japanese (0%). The prevalence of C/A1753 in Vietnamese was higher than that in the Japanese (32% vs. 17.1%), however the frequency of A1896 in the Japanese was significantly higher (32.9% vs. 12%, P < 0.05). Most of the Vietnamese patients with HCC had a high level of HBV-DNA, the Japanese HCC had a relatively low level. In the Vietnamese, C/ A1753 and C1858 were associated closely with T1762A1764, higher HBV-DNA levels and higher HCC incidence. The multivariate analysis revealed that male, T1653 and C/A1753 were independent risk factors for HCC. The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients.

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Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma

Kim

Chang²,

Lee

et al. 2009

Journal of Medical Virology

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Recently, hepatitis B virus (HBV) genotypes and mutations have been reported to be related to hepatocellular carcinoma (HCC). This cross-sectional case-control study examined the relationship between HCC and mutations in the enhancer II/core promoter and precore regions of HBV by comparing 135 Korean HCC patients infected with HBV genotype C2 (HBV/C2; HCC group) with 135 age-, sex-, and hepatitis B e antigen (HBeAg) status-matched patients without HCC (non- HCC group). Age and sex were also matched between HBeAg-positive and -negative patients. The prevalence of T1653, A1689, V1753, T1762/A1764, T1846, A1850, C1858, and A1896 mutations was evaluated in this population. The prevalence of the T1653 mutation in the box alpha region, the T1689 [corrected] mutation in between the box alpha and beta regions, and the T1762/A1764 mutations in the basal core promoter region was significantly higher in the HCC group compared to the non-HCC group (8.9% vs. 2.2%, P = 0.017; 19.3% vs. 4.4%, P < 0.001; and 60.7% vs. 22.2%; P < 0.001). Among HBeAg-negative patients, the frequency of the T1653 mutation was higher in the HCC group. Regardless of HBeAg status, the prevalence of the T1689, [corrected] and T1762/A1764 mutations was higher in the HCC group than in the non-HCC group. However, no association was observed between mutations in the precore region and HCC. Upon multivariate analysis, the presence of the T1653, T1689, [corrected] and T1762/A1764 mutations was an independent predictive factor for HCC. The addition of the T1653 or T1689 [corrected] mutation to T1762/A1764 increased the risk of HCC. In conclusion, the T1653, T1689, [corrected] and/or T1762/A1764 mutations were associated with the development of HCC in Korean patients infected with HBV/C2.

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Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam

Cited by 32 publications

References 36 publications

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Variations in the core promoter/pre‐core region in HBV genotype C in Japanese and Northern Vietnamese patients

Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma

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