Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor

Lin, Kuan‐Hung; Wang, Shwu Huey; Fong, Tsorng Harn; Chou, Duen Suey; Chang, Chao; Chang, Nen Chung; Chiang, Yung Chen; Huang, Shih‐Yi; Sheu, Joen Rong

doi:10.1007/s00109-014-1140-7

Cited by 23 publications

(19 citation statements)

References 34 publications

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“…PLTs also express a variety of dopamine receptors, being able to take up, store, and release dopamine . In addition, high levels of GABA were observed in PLTs, but the uptake system for GABA is unknown . GABA is released upon PLT stimuli and inhibits collagen‐induced aggregation .…”

Section: Discussionmentioning

confidence: 79%

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Transcriptomic profiling of platelet senescence and platelet extracellular vesicles

Pienimaeki‐Roemer¹,

Konovalova²,

Musri

et al. 2016

Transfusion

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Section: Discussionmentioning

confidence: 79%

“…In addition, high levels of GABA were observed in PLTs, but the uptake system for GABA is unknown . GABA is released upon PLT stimuli and inhibits collagen‐induced aggregation . Interestingly, we detected increased DRD2 and GABRR3 mRNA in senescent PLTs.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic profiling of platelet senescence and platelet extracellular vesicles

Pienimaeki‐Roemer¹,

Konovalova²,

Musri

et al. 2016

Transfusion

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“…It has been reported that likely through the PLC-γ and Ca 2+ pathway, CCR5 engagement activates AMPK to stimulate glycolysis (Chan et al, 2012 ; Lin et al, 2014 ). However, our present data suggested that CCR5-triggered AMPK activation was able to promote glycogen synthesis, not glycogenolysis, as a means to store energy in skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice

et al. 2016

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We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 to increase muscle glycogen storage and enhance muscle endurance (Lei et al., 2016). To explore the underlying molecular mechanisms, we investigated the role of AMP-activated protein kinase, a critical fuel sensor in skeletal muscle, in C-C chemokine receptor type 5-mediated orosomucoid action. It was found orosomucoid increased skeletal muscle AMP-activated protein kinase activation in a time- and dose- dependent manner, which was largely prevented by pharmacological blocking or knockout of C-C chemokine receptor type 5. Administration of orosomucoid also significantly increased the de-phosphorylation and activity of muscle glycogen synthase, the rate-limiting enzyme for glycogen synthesis. The effect was largely absent in mice deficient in C-C chemokine receptor type 5−/− or AMP-activated protein kinase α2−/−, the predominant isoform in skeletal muscle. Moreover, deletion of AMP-activated protein kinase α2 abolished the effect of orosomucoid on fatigue and muscle glycogen. These findings indicate that orosomucoid may promote glycogen storage and enhance muscle function through C-C chemokine receptor type 5-mdiated activation of AMP-activated protein kinase, which in turn activates glycogen synthase and increases muscle glycogen.

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“…However, their characterizations were solely based on radioligand-binding studies and no actual receptor was delineated. Thus, any translation of the interesting findings reported by Lin et al [6] will have to await more extensive pharmacological investigations.…”

mentioning

confidence: 98%

“…Lin et al in this issue of J Mol Med also focused on platelets [6]. They reasoned that since platelets take up GABA and as they harbor binding sites for benzodiazepines that seem to inhibit platelet aggregation, platelet function could be influenced by GABAergic mechanisms.…”

mentioning

confidence: 99%

GABA the Hutt

Luft

2014

J Mol Med

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Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor

Abstract: GABA is abundantly distributed in the platelets. GABA inhibited platelet activation stimulated by convulxin. GABA directly associated with glycoprotein VI in platelet membrane. GABA prolonged the closure time of whole blood and the occlusion time of platelet plug formation in vivo.

Cited by 23 publications

References 34 publications

Transcriptomic profiling of platelet senescence and platelet extracellular vesicles

Transcriptomic profiling of platelet senescence and platelet extracellular vesicles

ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice

GABA the Hutt

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