Characteristics of intraretinal deposits in acute central serous chorioretinopathy

Abstract

PurposeTo describe the temporal and spatial characteristics of intraretinal deposits in patients with acute central serous chorioretinopathy (CSC) using spectral domain optical coherence tomography (OCT).Materials and methodsWe retrospectively reviewed the medical records of all patients that presented with acute CSC to Weill Cornell Medical College from January 2012 to May 2013. Acute CSC was defined as a diagnosis of CSC within 4 months of the onset of symptoms. Only one eye per patient was included in the study. Each patient was imaged with spectral domain OCT at the initial office visit. The decision to reimage these patients was made by the treating physician.ResultsA total of 25 patients (25 eyes; 17 men and eight nonpregnant women) were included in this review. Seven of 25 patients (28%) demonstrated intraretinal deposits within the outer plexiform layer during the initial OCT, with deposits appearing as early as the same day as the onset of symptoms. A total of 25 of 25 patients (100%) demonstrated intraretinal deposits in the outer nuclear layer upon initial (76%) or follow-up OCT, as early as 2 days after the onset of symptoms. A total of 24 of 25 patients (96%) demonstrated deposits in the external limiting membrane upon a follow-up OCT, as early as 7 days from symptoms appearing. A total of 24 of 25 patients (96%) developed intraretinal deposits in the inner segment/outer segment layer upon follow-up OCT, appearing as early as 14 days after symptom onset. At the time of resolution of subretinal fluid, 20 of 25 patients (80%) demonstrated intraretinal deposits.ConclusionIntraretinal deposits are present in the outer retinal layers in patients with acute CSC, with the deposits appearing progressively deeper within the retina as the condition evolves. Upon resolution of subretinal fluid, the deposits slowly resolve.

Macular outer plexiform layer and outer nuclear layer thickness on spectral domain optical coherence tomography in central serous chorioretinopathy — a case of two patients

“…Similar hyper-reflectivity on SD-OCT was observed by Ouyang et al in a 49-year-old patient with unilateral CSC, believing it to be caused by slight tilting during scan acquisition [4]. Moreover, Plateroti et al have described intraretinal deposits within the outer plexiform layer visible on SD-OCT in 7 out of 13 patients examined, with acute CSC appearing at different times in the course of the disease [5].…”

Correlation between baseline retinal microstructures in spectral-domain optic coherence tomography and need for early intervention in central serous chorioretinopathy

“… 11 The appearance of intraretinal/subretinal hyper-reflective areas could be seen as early as the same day of symptom onset, followed by progression to the deeper retinal layer. 10 According to the known importance of the presence of intraretinal and/or subretinal hyper-reflective dots, the current results offer the first evidence on its significance in predicting the need for early intervention.…”

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

“…Concentration of protein-like compounds, fibrin or lipids could also be identified as dots (Kon et al, 2008). During acute CSCR evolution, the intraretinal hyper-reflective dots progress from the inner to the outer retinal layers and slowly resolve upon resolution of SRD (Plateroti et al, 2014). Chronic and recurrent forms of CSCR are more frequently associated with intraretinal hyper-reflective dots (Ojima et al, 2007).…”