Characteristics of Patients with Mild to Moderate Primary Pulmonary Coccidioidomycosis

Blair, Janis E.; Chang, Yu Hui; Cheng, Meng Ru; Vaszar, Laszlo T.; Vikram, Holenarasipur R.; Orenstein, Robert; Kusne, Shimon; Ho, Stanford; Seville, Maria Teresa; Parish, James M.

doi:10.3201/eid2006.131842

Cited by 57 publications

(44 citation statements)

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“…For most healthy persons with mild to moderate infection limited to the lungs, systemic and pulmonary symptoms can last anywhere from a couple of weeks to a few months. 85 Patients may experience profound fatigue that can persist for 6 months or longer. 85 Antifungal treatment does not ameliorate the fatigue, although many patients benefit from gradually progressive aerobic exercise or supervised physical therapy.…”

Section: Resultsmentioning

confidence: 99%

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Pulmonary Coccidioidomycosis

Kimes

Kasule

Blair

2020

Semin Respir Crit Care Med

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Coccidioidomycosis is an infection caused by the geographically restricted dimorphic fungus, Coccidioides. Coccidioidomycosis occurs endemically in the southwestern and western United States, mainly in focused regions of Arizona and California where the incidence is highest, and in Central and South America. Patients with impaired immunity, especially those with impaired cellular immunity, are at higher risk of severe and disseminated disease. In this review, we describe the fungal ecology and mycology, epidemiology, pathophysiology, and normal immune defenses to Coccidioides as well as address current concepts in diagnosis, treatment, and continued care of patients with pulmonary coccidioidomycosis. We also present and answer our most frequently asked questions regarding patients with primary pulmonary coccidioidomycosis.

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Section: Resultsmentioning

confidence: 99%

“…85 Patients may experience profound fatigue that can persist for 6 months or longer. 85 Antifungal treatment does not ameliorate the fatigue, although many patients benefit from gradually progressive aerobic exercise or supervised physical therapy. 86 therapy, although treatment depends on the type and severity of disease.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary Coccidioidomycosis

Kimes

Kasule

Blair

2020

Semin Respir Crit Care Med

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“…Published reports have demonstrated activity of all of these agents in treatment of complicated coccidioidal infections, but there are no randomized trials demonstrating that any of these drugs shorten the course of early uncomplicated infections or prevent later complications. Two recent observational studies also provide no evidence for a beneficial effect in the pharmacologic treatment of early coccidioidal pneumonia (11,12).…”

Section: Diffuse Fulminant Pneumoniamentioning

confidence: 99%

Valley fever (coccidioidomycosis): turtorial for primary care physicians

Excellent

2015

Southwest J Pulm Crit Care

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In the south and central deserts of Arizona and the central valley of California, Valley Fever should be a familiar phrase to clinicians and patients alike. It is estimated that over 50,000 persons each year, or approximately 1% of the population within the most endemic regions, seek medical care for newly acquired Valley Fever infections. Certain medical and surgical specialists practicing in these areas are particularly likely to be aware of the less frequent but more serious complications of the disease. In recent years, both the Centers for Disease Control and Prevention and the Arizona Department of Health Services have contributed significantly to our understanding of Valley Fever as a public health problem. However, despite the significant impact of these complications on regional public health and individual lives, the majority of these infections are managed by primary care clinicians either without an accurate diagnosis or with sub-optimal care. In January 1996, the Valley Fever Center for Excellence established a hotline that physicians and others with questions about Valley Fever could call for information. From the questions received through the hotline, it became increasingly apparent that many details about the causes of and necessary responses to Valley Fever were not fully understood. One area of particular importance was the need for timely diagnosis and proper management of the initial respiratory infection. Early diagnosis of Valley Fever by primary care professionals can improve patient care by reducing patient anxiety, unneeded diagnostic tests, and unwarranted use of antibacterial agents. Moreover, early appropriate treatment can reduce the incidence of serious complications requiring additional treatment. We hope to improve this situation with this revised edition of Valley Fever (Coccidioidomycosis) Tutorial for Primary Care Professionals. The purposes of this monograph are twofold. First, it is intended to be a syllabus to accompany a medical education program on the primary care aspects of coccidioidomycosis organized by the Valley Fever Center for Excellence. Slide presentations from the CME program can be found at the Valley Fever Center for Excellence website (www.vfce.arizona.edu). While this syllabus does not follow the presentation structure of the CME program, it covers much of the same information. Medical centers, health maintenance organizations, or other medical groups interested in bringing this program to their site for their clinicians can arrange to do so by

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“…Nach einer Inkubationszeit von einer bis drei Wochen treten Fieber, Arthralgien und Husten auf. Im US-Bundesstaat Arizona ist die primäre Lungen-Coccidioidomycose für 15 %-29 % der ambulant erworbenen Pneumonien verantwortlich [80]. Leichtere bis mittelschwere Formen sind überwiegend durch unilaterale oder bilaterale Rundherde < 5 cm gekennzeichnet.…”

Section: Protozoenunclassified

Pneumonien mit Reiseanamnese

Geerdes-Fenge

2014

Pneumologie

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Respiratory infections are responsible for up to 11% of febrile infections in travellers or immigrants from tropical and subtropical regions. The main pathogens are the same as in temperate climate zones: Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, influenza viruses, Legionella pneumophila. However, some pulmonary diseases can be attributed to bacterial, parasitic, viral or fungal pathogens that are endemic in tropical and subtropical regions. The most commonly imported infections are malaria, dengue, and tuberculosis. Pulmonary symptoms and eosinophilia in returning travellers and migrants may be caused by several parasitic infections such as Katayama syndrome, Loeffler syndrome, tropical pulmonary eosinophilia, amebiasis, paragonimiasis, echinococcosis, and toxocariasis. In Asia, Tsutsugamushi fever is transmitted by chiggers, spotted fever rickettsiae are transmitted by ticks. Transmission of zoonotic diseases occurs mainly via contact with infected animals or their excretions, human-to-human transmission is generally rare: MERS-CoA (dromedary camels), pulmonary hantavirus infection (rodents), tularemia (rabbits and hares), leptospirosis (rats), Q-fever (sheep and goats), very rarely anthrax (hides of ruminants) and pest (infected rats and wildlife). Inhalation of contaminated dust can cause infections with dimorphic fungi: histoplasmosis (bat guano) and coccidioidomycosis in America and parts of Africa, blastomycosis in America. Some infections can cause symptoms years after a stay in tropical or subtropical regions (melioidosis, tuberculosis, histoplasmosis, schistosomiasis-associated pulmonary hypertension). Noninfectious respiratory diseases caused by inhalation of high amounts of air pollution or toxic dusts may also be considered.

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Characteristics of Patients with Mild to Moderate Primary Pulmonary Coccidioidomycosis

Abstract: Convalescence is prolonged, regardless of whether the patient receives treatment.

Cited by 57 publications

References 26 publications

Pulmonary Coccidioidomycosis

Pulmonary Coccidioidomycosis

Valley fever (coccidioidomycosis): turtorial for primary care physicians

Pneumonien mit Reiseanamnese

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