Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate

Takahashi, T.; Takayama, K.; Machida, Yoshiharu; Nagai, Tsuneji

doi:10.1016/0378-5173(90)90041-2

Cited by 161 publications

(59 citation statements)

References 10 publications

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“…Also, the polyion complexation between chitosan and anionic polymers depends on the pH value of the media, the ionic strength, and temperature (Takahashi et al 1990). Polk et al (1994) investigated the effect of the pH of gelling medium containing chitosan on microparticle strength and flexibility and reported that the strength and flexibility of the microparticle membrane were maximal as the pH of the chitosan solution increases to 5.5.…”

Section: Drug Release Studiesmentioning

confidence: 99%

Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Cekić¹,

Savić²,

Milić³

et al. 2007

Drug Delivery

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Section: Drug Release Studiesmentioning

confidence: 99%

Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Cekić¹,

Savić²,

Milić³

et al. 2007

Drug Delivery

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“…36 The negatively charged carboxylic acid groups of alginate bind ionically with positively charged amino groups of chitosan, a cationic polymer, to form a polyelectrolyte complex on the basis of their opposite charges. 37 Moreover, chitosan has been reported to enhance absorption of various compounds across the mucosal barrier owing to its properties of mucoadhesion, which increase the contact time of the drug with the mucosa, and its ability to induce a transient opening of epithelial cell tight junctions. [38][39][40] Alginate microspheres prepared by internal gelation and cross-linked with chitosan were applied in the encapsulation of DNA 24 , 26 , 27 and Sudan Orange G. 41 Encapsulation of bioactive compounds, such as proteins and DNA, by either internal gelation or external gelation revealed that in ternal gelation provides a better encapsulant protection from hydrolysis 24 but may permit higher losses from microspheres.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification/internal gelation

Silva

Ribeiro²,

Figueiredo

et al. 2005

AAPS J

106

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A BSTRACTChitosan-coated alginate microspheres prepared by emulsification/internal gelation were chosen as carriers for a model protein, hemoglobin (Hb), owing to nontoxicity of the polymers and mild conditions of the method. The infl uence of process variables related to the emulsifi cation step and microsphere recovering and formulation variables, such as alginate gelation and chitosan coating, on the size distribution and encapsulation effi ciency was studied. The effect of microsphere coating as well its drying procedure on the Hb release profi le was also evaluated. Chitosan coating was applied by either a continuous microencapsulation procedure or a 2-stage coating process. Microspheres with a mean diameter of less than 30 μm and an encapsulation effi ciency above 90% were obtained. Calcium alginate cross-linking was optimized by using an acid/CaCO 3 molar ratio of 2.5, and microsphere-recovery with acetate buffer led to higher encapsulation effi ciency. Hb release in gastric fl uid was minimal for air-dried microspheres. Coating effect revealed a total release of 27% for 2-stage coated wet microspheres, while other formulations showed an Hb release above 50%. Lyophilized microspheres behaved similar to wet microspheres, although a higher total protein release was obtained with 2-stage coating. At pH 6.8, uncoated microspheres dissolved in less than 1 hour; however, Hb release from air-dried microspheres was incomplete. Chitosan coating decreased the release rate of Hb, but an incomplete release was obtained. The 2-stage coated microspheres showed no burst effect, whereas the 1-stage coated microspheres permitted a higher protein release.

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“…Sodium alginate is soluble in water, whereas calcium induces the formation of a gel [97,100]. Apart from the interaction with calcium, alginate may also form complexes with polycations such as polyenimine (PEI), chitosan, or basic peptides like polylysine and polyarginine [100][101][102].…”

Section: Alginatementioning

confidence: 99%

Biopolymeric nanoparticles

Sundar

Kundu

2010

Science and Technology of Advanced Materials

292

159

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This review on nanoparticles highlights the various biopolymers (proteins and polysaccharides) which have recently revolutionized the world of biocompatible and degradable natural biological materials. The methods of their fabrication, including emulsification, desolvation, coacervation and electrospray drying are described. The characterization of different parameters for a given nanoparticle, such as particle size, surface charge, morphology, stability, structure, cellular uptake, cytotoxicity, drug loading and drug release, is outlined together with the relevant measurement techniques. Applications in the fields of medicine and biotechnology are discussed along with a promising future scope.

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Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate

Cited by 161 publications

References 10 publications

Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification/internal gelation

Biopolymeric nanoparticles

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