Characteristics of polyurethane-based sustained release membranes for drug delivery

Abstract

This paper is focused on the preparation and physicochemical characterization of two poly(ester ether urethane)s with rifampicin in their matrix and different molar concentrations of urethane groups. The polyurethanes with rifampicin were processed as asymmetrical microporous membranes by a phase inversion method and characterized by attenuated total reflection — Fourier transform infrared (ATR-FTIR) spectroscopy and differential scanning calorimetry (DSC). The influence of the surface morphology in the release of drug compounds was analyzed by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle, and water uptake. The release of rifampicin depends on the molar concentration of urethane groups and also on the surface morphology of the polyurethane membranes. The antibacterial activity was evaluated with S. Epidermidis RP 62 A and P. Aeruginosa ATCC 1544. Finally, the biocompatibility of the polyurethane membranes was studied with human dermal fibroblasts (HDF) to evaluate the potential biomedical applications.

Grafting of N‐vinyl caprolactam and methacrylic acid onto silicone rubber films for drug‐eluting products

“…The grafting of PVCL and PMAA also provided SR with the ability to take up nystatin [Figure (c)]. Nystatin is a large (926.1 Da) amphiphilic polyene antifungal agent that can establish hydrophobic interactions through its conjugated double bonds, and it can form hydrogen bonds with amide and carboxylic groups from grafted copolymers through its hydroxyl groups . This resulted in higher loading amounts compared to the NSAIDs.…”

Investigation of Properties of Nanofibers From Collagen and Polyethylene Terephthalate Using a Natural Cross-Linker

“…The combination of natural and synthetic components give the possibility of obtaining many composites with improved properties. [1][2][3] The optimal features of nanofibers obtained from natural materials promote cell repopulation and formation of new tissue. Collagen type I is the most abundant protein in the extracellular matrix and also in the human body, it is a fibrillar protein with a long and rigid structure that provides the mechanical and physical characteristics of tissues.…”

Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

“…Mândru [20] synthesized a poly(ester-ether urethane) using poly(butylene adipate) diol and PEG as soft segments and MDI together with 1,4-butanediol (BDO) as hard segments, from which the antibiotic rifampicin was released in a controlled manner depending on the molar concentration of urethane groups in the polymer chains as well as the surface morphology of the polyurethane membranes.…”