Characterization and Clinical Application of the ???Significance Band??? For Acute Respiratory Alkalosis

Arbus, Gerald S.; Hebert, Lee A.; Lévesque, Renée; Etsten, Benjamin E.; Schwartz, William B.

doi:10.1097/00132586-197008000-00033

Cited by 12 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter is caused by a significant mechanism. This is supported by our finding of a reduction in alveolar carbon dioxide tension, statistically significant negative correlation beresulting from a significant increase of the alveolar tween paC0 2 , and blood lactate (r = -0.497, Ventilation [4], and unaltered alveolar tensions of P= 0.001), and between the pH and blood pyruvate nitrogen and water vapor. In a recent report, there (r= -0.367, P= 0.021).…”

Section: Discussionsupporting

confidence: 83%

“…Such bands have been constructed in reported reduced HCO 3 " levels in normal pregnancy humans for acute and chronic hypercapnia [5] [ 1,7,14,15,24]. The mean blood BE was found m^ acute hypocapnia [2]. Comparable data in man to be -4.22 ± 2.22 mEq/L which is less than in with chronically adapted respiratoiy alkalosis are normal adult women [29], in agreement with no t available, the longest period of observation previousreports [l,6,7, 14, 24].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we proceeded to construct from our data confidence bands correlating the H + concentration (pH) and HC0 3 " to paC0 2 levels. Regression lines were calculated from 43 cases of paired data: H + = 28.3 + 0.335 paC0 2 HC0 3 ' = 4.63 + 0.499 paC0 2 The Standard error of these regression lines at the 95 % level was then calculated and the bands plotted [25] (Figs. 3 and 4).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Normal pregnancy: A model of sustained respiratory alkalosis

Fadel¹,

Northrop²,

Misenhimer³

et al. 1979

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Normal pregnancy: A model of sustained respiratory alkalosis

Fadel¹,

Northrop²,

Misenhimer³

et al. 1979

Journal of Perinatal Medicine

View full text Add to dashboard Cite

“…This same shortcoming is present for the clinical diagnosis of acute respiratory alkalosis, which is similarly well characterized only for the acute steady state (27).…”

Section: Discussionmentioning

confidence: 99%

Acute Metabolic Acidosis

Wiederseiner

Muser²,

Lutz

et al. 2004

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Abstract. Despite the high incidence of acute metabolic acidosis, there are no reliable human data to enable physicians to accurately diagnose this disorder. In addition, there is uncertainty about the direction and magnitude of plasma potassium changes in acute metabolic acidosis. The systemic and renal acid-base, electrolyte, and endocrine response to acute acid loads (imposed by three timed NH 4 Cl infusions into the duodenum, 0.9 mmol of NH 4 Cl per kg of body weight over 30 min each) was characterized in six healthy male subjects in whom a metabolic steady-state had been established. Arterialized blood CO 2 tension decreased by 0.85 mmHg per mmol/L decrease in plasma bicarbonate concentration and blood hydrogen ion concentration increased by 0.45 nmol/L per mmol/L decrease in plasma bicarbonate concentration. Plasma potassium did not change significantly (ϩ0.02 Ϯ 0.02 mmol/L per mmol decrease in plasma bicarbonate concentration). Plasma insulin increased and plasma glucagon levels decreased in acute metabolic acidosis, while catecholamines and aldosterone were not affected significantly. These data provide the first diagnostic criteria for the diagnosis of acute metabolic acidosis in humans. The finding of a hyperinsulinemic response in acute metabolic acidosis suggests that an insulin response counterregulates any acidemia-induced cellular potassium efflux, resulting in stable plasma potassium concentrations.

show abstract

“…These processes are intimately linked to the regulation of potassium as well. Finally, the kidney responds to the challenges of primary respiratory disorders to offset the effects of these disturbances in a predictable fashion (51,52). In chronic respiratory alkalosis, the kidney can decrease acid excretion by decreasing ammonia production and bicarbonate retention; in respiratory acidosis, activity of the Na-H antiporter is augmented so that more bicarbonate is reabsorbed (53).…”

Section: Acid-base Homeostasismentioning

confidence: 99%

Homeostasis, the Milieu Intérieur, and the Wisdom of the Nephron

Hoenig

Zeidel

2014

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The concept of homeostasis has been inextricably linked to the function of the kidneys for more than a century when it was recognized that the kidneys had the ability to maintain the "internal milieu" and allow organisms the "physiologic freedom" to move into varying environments and take in varying diets and fluids. Early ingenious, albeit rudimentary, experiments unlocked a wealth of secrets on the mechanisms involved in the formation of urine and renal handling of the gamut of electrolytes, as well as that of water, acid, and protein. Recent scientific advances have confirmed these prescient postulates such that the modern clinician is the beneficiary of a rich understanding of the nephron and the kidney's critical role in homeostasis down to the molecular level. This review summarizes those early achievements and provides a framework and introduction for the new CJASN series on renal physiology.

show abstract

Characterization and Clinical Application of the ???Significance Band??? For Acute Respiratory Alkalosis

Cited by 12 publications

References 0 publications

Normal pregnancy: A model of sustained respiratory alkalosis

Normal pregnancy: A model of sustained respiratory alkalosis

Acute Metabolic Acidosis

Homeostasis, the Milieu Intérieur, and the Wisdom of the Nephron

Contact Info

Product

Resources

About