Characterization and fabrication of Nd:YVO4 disc laser system

Diam, Wajeha Abdle; Al-Timimi, Zahra

doi:10.1063/1.5116936

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…Excess of free radicals in the body may lead to alteration of molecular chemical structures and conformation when they damage the hydrogen bonds of membrane proteins [1,15]. In studies by Yanhong et al, they observed that chemical activity and red blood cells membrane stability are increased following low-energy irradiation of the cells [16]. These poikilocytes are present in pathological conditions signifying an elevation of free radicals in blood which has a negative impact of deforming these vital cells.…”

Section: Resultsmentioning

confidence: 99%

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

2020

Lett Appl NanoBioSci

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Lasers have been applied in various clinical procedures such as surgery and cardiology to clear occluded blood vessels. However, there subsists insight into the relevant parameters and their ability to develop a rheological property of blood. Two blood samples were used. Morphological changes that have been chosen to detect this effect on red cells were: echinocytes, dacrocytes, stomatocytes, keratocytes , schistocytes. Laser beams λ = 532nm , power 100 mw at different intervals (0, 1, 3, 6, and 10 seconds).Six slides prepared for each interval. Slides were irradiated and microscopic photographs were taken to observe changes in population of each poikilocytes were compared to non-irradiated control blood smears. The effects were listed in a table in the form of a scale. Various laser energy doses were able to reduce the population of some poikilocytes namely ( dacrocytes, stomatocytes) in a male and (echinocytes, dacrocytes, stomatocytes, keratocytes and schistocytes) in a female by one, two or three cells. A poikilocyte is a distorted red blood cell and bears different forms, for instance, created (echinocytes), teardrop (dacrocytes), bite cells (keratocytes) or even fragmented (schistocytes). Low-energy laser improves the monographic properties of red cells by enhancing ATPase activity, metabolic output, activity of antioxidant enzymes.

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Section: Resultsmentioning

confidence: 99%

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

2020

Lett Appl NanoBioSci

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“…Remarkable studies have determined that the deficiencies that transpire in infected wound healing can be indicated by the modified collagen metabolism, furthermore, the abnormal granulation tissue formation. 28,29…”

Section: Discussionmentioning

confidence: 99%

“…26,27 Remarkable studies have determined that the deficiencies that transpire in infected wound healing can be indicated by the modified collagen metabolism, furthermore, the abnormal granulation tissue formation. 28,29 Al-Watban 30 recommended that using 532 nm laser with 143 MW power; spot size 7 cm 2 ; power density 20.4 mW/ cm 2 ; and incident doses 5, 10, 20, and 30 J/cm 2 applied to intensify wound healing in diabetic rats, combined with medication schedule 3 (periods/week). They assumed that the acknowledgement of healing developed in all the utilized doses.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Significance of Constant Laser Therapy, 532 nm, in Various Exposure Times on the Healing Process of Wounds Infected by Acinetobacter baumannii

Al-Timimi

2021

The International Journal of Lower Extremity Wounds

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Many considerable investigations focused on the stimulation of therapeutic manners of infected injuries in mice. The exaggerated pathogens that induced wounds were gram-positive like staphylococcal and gram-negative, for example, Pseudomonas aeuroginosa and Acinetobacter baumannii. Acinetobacter can generate a scale range of an infection that may be received in a hospital or any wellness concern facility. In order to know the significance of laser 532 nm with a constant irradiance at various exposure times on the healing process of wounds infected by Acinetobacter baumannii, this study was performed on the BALB/C mice. An elliptical full-thickness skin injury was made on the backside of 45 adult female (BALB/C) mice. Injuries were affected via Acinetobacter baumannii and were randomly assigned into 3 groups. Semiconductor diode continuous wave laser, λ = 532 nm, with output power 40 mW was used. The power density was 5.71 mW/cm2, while the fluencies were 1.7 J/cm2 and 5.14 J/cm2. Fifteen mice were classified according to the times of irradiation. The first group was infected and presented as control, without irradiation. The second group was infected and irradiated for 5 minutes. The third group, likewise, was infected but irradiated for 15 minutes. All groups were subdivided according to the following period, 3, 5, and 10 days, after irradiation and the animals were killed after the treatment. Wound healing was made by measuring the rate of wound closure and histopathological evaluation. The study determined that 532 nm laser therapy had an obvious and positive influence on the healing of infected wounds with fluence (5.14 J/cm2).

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“…21 It should have a great absorption peak within 600nm-800nm because of the absorption of photons with wavelengths higher than 800nm does not produce enough energy to stimulate the oxygen to its singlet state so as the ability for creating a substantial yield of reactive oxygen species simultaneous irradiation. 15,16 Considering the penetration of light within the tissue increases with its wavelength, the agents with a strong absorbance in the intense red essentially like chlorins, bacteriochlorins, and phthalocyanines advance improvement in tumor control. It should have no obscure toxicity and approximately rapid clearance from the normal tissues, whereby minimizing phototoxic side impressions.…”

Section: Application Of Photosensitisers In Cancer Therapymentioning

confidence: 99%

“…13 Through direct targeting of irradiation source on hyper proliferative tissue and its discriminatory absorption at the targeted site gives PDT its double selectivity with minimal damage to the adjacent normal tissues. 14,15 CPDT can be used to treat some cancers or in precancerous conditions when the tumour, is on or near to the lining of internal organs like cancers that affect the oesophagus, head and neck, lung, mouth and skin (but not melanoma). 14,16 The biological damage happen as a result of the optical irritation of a photosensitizer in the existence of oxygen which is generally indicated to as "Photodynamic Action".…”

Section: Introductionmentioning

confidence: 99%

Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

Timimi

2021

Bangladesh Med Res Counc Bull

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Background: Cancer Photodynamic Therapy (CPDT) is a promising future treatment quality based on the selective accumulation of a photosensitiser in the malignant tissues and the dependent irradiation with laser light. Objective: The aim of this work was to estimate an optimum effect involves the performance of a photosensitizing agent served by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the appearance of oxygen, a series of effects lead to direct tumour cell death and damage to the microvasculature and initiation of a local inflammatory reaction. Methods: Photosensitiser is a material that sensitizes an organism, cell, or tissue to the light. It is a deeprooted part of CPDT, which absorbed by cancerous cells and exposed to laser light, gets activated, damaging and killing cancer cells. The direct targeting of laser source on hyper proliferative tissue and its preferential origin absorption at the targeted site gives rise CPDT double selectivity with least damage to adjacent normal tissues. Results: Photosensitiser absorbs the light and then produces an active form of oxygen, which destroys nearby cancer cells. The photosensitiser is able to spoil the blood vessels in the tumour, that way preventing cancer from receiving any necessary nutrients. The light which needed to activate most of the photosensitisers cannot pass through more than about one-third of an inch of tissue, because of that reason, the CPDT is usually used to treat cancer on or just under the skin or on the lining of internal organs. In addition, CPDT may activate the immune system to attack the tumour cells, directly killing cancer cells. Conclusion: This review focuses on the aspects of CPDT as an advanced and original site directed therapy for cancer treatment and the other non-oncogenic diseases. Minimal average of tissue toxicity controlled a long-term morbidity, deficiency of intrinsic or acquired resistance mechanisms. Bangladesh Med Res Counc Bull 2020; 46(3): 150-153

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Characterization and fabrication of Nd:YVO4 disc laser system

Cited by 4 publications

References 13 publications

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

Evaluation of the Significance of Constant Laser Therapy, 532 nm, in Various Exposure Times on the Healing Process of Wounds Infected by Acinetobacter baumannii

Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

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