Characterization and In Vitro Drug Release Studies of a Natural Polysaccharide Terminalia catappa Gum (Badam Gum)

Meka, Venkata Srikanth; Nali, Sreenivasa Rao; Songa, Ambedkar Sunil; Kolapalli, Venkata Ramana Murthy

doi:10.1208/s12249-012-9873-5

Cited by 44 publications

(19 citation statements)

References 25 publications

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“…From the plots, shown in figures 8 and 9 it was concluded that there was a significant effect of concentration of Badam gum and concentration of HPMC K 15 M on bioadhesion strength. However, the effect of the polymer Badam gum was more pronounced than HPMC K4 M on bioadhesion strength since Badam gum has significant sticking property these findings are in agreement with previously reported results by Meka, et al, [23] who found the Badam gum has remarkable swelling and sticking character in gastric pH. [23][24][25][26][27][28][29][30][31][32][33] This developed floating-bioadhesive combination formulation would overcome the drawback of floating and bioadhesive individual system and improving the therapeutic effect of the drug involved.…”

Section: Bioadhesive Strengthsupporting

confidence: 90%

“…This gel layer governs the drug released from the matrix tablet. The floating tablets containing Badam gum and HPMC K15M with showed constant increased in swelling because Badam gum and HPMC K15M showed higher swelling and can maintain their matrix integrity for more than 8-9 h similar observation are reported by Meka, et al [23] this erosion of polymer dominates over water sorption after 8 h hence the reduction in tablet weight occurs after 9 h because of constant due to constant erosion of matrix. It might be due to increased hydration of the formed gel layer with time resulted in chain disentanglement and dissolution of the gel layer (erosion), thus decreased SI.…”

Section: Swelling Studysupporting

confidence: 77%

“…The final blend was then compressed into tablets on a 9 station rotary tablet machine (Rimek Mini Press -II, Karnavati, Ahmadabad, India) using 9mm round plain punches. [23,24] Characterizations of GRDF…”

Section: Formulation Of Floating Bioadhesive Tablets Of Simvastatinmentioning

confidence: 99%

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Nawaj¹

2017

AJP

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Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.

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Section: Bioadhesive Strengthsupporting

confidence: 90%

Section: Swelling Studysupporting

confidence: 77%

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Nawaj¹

2017

AJP

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“…There are only a few reports of the use of the almond gum in the development of SR formulations. [5,6] A lipophilic polymer gelucire (43/01) is also employed in the formulation of single unit matrix tablets. Gelucires are a family of relatively inexpensive materials, comprising mixtures of mono-, di-, and triglycerides and also poly (ethylene glycol) esters of fatty acid.…”

Section: Introductionmentioning

confidence: 99%

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Ramesh

2017

AJP

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Background: Multi-unit dosage forms such as microcapsules and microspheres offer the advantage of better control over the release and lesser chances of dose dumping. This is critical for drugs with high dose, and no comparative study between single and multi-unit forms for controlled release was done previously. Objectives: To explore the utility of using a combination of almond gum and gelucire for preparing sustained-release (SR) matrix tablets. To employ a novel technique of microencapsulating the alginate beads of captopril for SR. Materials and Methods: Almond gum, gelucire (43/01), and ethyl cellulose were the major polymers used. Direct compression and emulsion solvent evaporation methods were employed to prepare the matrix tablets and microcapsules. The prepared products were evaluated for drug release and characterized by scanning electron microscopy, differential scanning calorimetry (DSC), and infrared spectroscopic studies. Accelerated stability study was performed, and drug release was studied before and after stability test. Results and Discussion: Drug release from the matrix tablets could be modified by changing the proportion of gelucire or almond gum in the formulation. The combined use of almond gum and gelucire is found to be more effective in giving a slow, and complete release spread over 12 h. Infrared spectroscopic and DSC studies revealed that there are no interactions of captopril with the various polymers. The microcapsules of alginate beads prepared employing ethyl cellulose are found to be free flowing and had an average size in the range of 750-850 µ. The matrix tablets of captopril are found to be giving more controlled release for a longer period of 12 h compared to the microcapsules. Conclusion: Entrapping the drug in a lipophilic material such as gelucire or beeswax and preparing the calcium alginate microspheres which are subsequently microencapsulated is a promising new approach to obtain the SR of highly water soluble drugs such as captopril.

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“…It is medically used as a demulcent and for the treatment of asthma and coughing, while it may also be used as a flavoring agent or preservative (3). Mucilage are biopolymers most commonly used as adjuvants in the manufacturing of different pharmaceutical products and include binding, thickening, stabilizing, humidifying (4,5), disintegrating (6), suspending (7), emulsifying (8), and sustaining properties (9), at different proportions in many pharmaceutical dosage forms. Natural mucilage are preferred over semi-synthetic and synthetic materials due to their non-toxic, low cost, free availability, emollient and nonirritating nature (10).…”

Section: Introductionmentioning

confidence: 99%

Quince Seeds Biopolymer: Extraction, Drying Methods and Evaluation

Moghbel

Tayebi

2015

Jundishapur J Nat Pharm Prod

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Background: Quince seeds mucilage is recommended for coughs and removal of asthma signs. Chemically, it possesses water in a large quantity and therefore might be degradable and its storage is difficult for a long time. Besides, the drying method interferes with its physicochemical characteristic, therefore changing the therapeutic effect of mucilage. Objectives: The aim of this study was to achieve a drying method for promotion of quince seeds mucilage stability and also to study differences in physicochemical and mechanical properties when influenced by the drying method. Materials and Methods: To extract mucilage, fresh quince seeds were macerated with water. The alcohol (95%) precipitation method was used to isolate mucilage from filtrate. The mucilage was divided to two equal parts, one group dried by cold and the other by the warm method. The condition for the cold method (lyophilization) was 24 hours for both stages of freezing (-30°C) and drying (-50°C and 50 mTorr pressure). The temperature for drying by an oven was also adjusted to 50°C ± 1. Phytochemical screening was performed, and the physicochemical characteristics of the mucilage such as swelling index, solubility, loss of drying, total ash, acid insoluble ash, microbial load, and pH were evaluated. Finally, the mechanical movement of mucilage powder properties such as angle of repose, moisture content, bulk and tapped densities, Hausner's ratio and Carr's index, were examined, for forward tableting. Results: The yield value of mucilage from the warm method was about three folds greater than the amount from the cold method. The phytochemical, physicochemical, and mechanical properties were well within acceptable limits and better than that of the cold method. Conclusions: Although quince seeds dried mucilage by lyophilization had less yield amounts yet in view of purity and physicochemical and mechanical properties, it was significantly better than mucilage prepared by the oven method (P < 0.05).

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Characterization and In Vitro Drug Release Studies of a Natural Polysaccharide Terminalia catappa Gum (Badam Gum)

Cited by 44 publications

References 25 publications

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Quince Seeds Biopolymer: Extraction, Drying Methods and Evaluation

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