Characterization and Stability Evaluation of Thymoquinone Nanoemulsions Prepared by High‐Pressure Homogenization

Abstract

Despite the pharmacological properties of thymoquinone (TQ), its administrationin vivoremains problematic partly due to its poor water solubility, leading to low absorptivity and bioavailability. Hence, the objective of this study is to prepare, characterize, and evaluate the stability of TQ nanoemulsion (TQNE). Conventional emulsion from TQ (TQCE) and empty nano- and conventional emulsions from Triolein (TRNE and TRCE) are also produced for comparison purposes. The oil-in-water nanoemulsions of TQ and Triolein were produced by high-pressure homogenization. Emulsions were characterized physically by droplet size, polydispersity index, zeta potential, and refractive index. The changes of these parameters in TQNE samples stored for 6 months at 4 and 25°C were not statistically significant (P<0.05). In addition, the initial particle sizes of TQNE and TRNE were 119.6 and 119.5 nm, respectively. Stability studies were also performed for the period of 6 months. At the end of the experiment, the percent of remaining TQ in TQNE at 4, 25, and 40°C was 90.6, 89.1, and 87.4 % respectively. Slower degradation of TQ indicated the chemical stability of TQ in TQNE samples. These results indicated that TQNE is stable over a period of 6 months.

Stability and Biological Activity Evaluation of Chlorantraniliprole Solid Nanodispersions Prepared by High Pressure Homogenization

“…Homogenization condition has a significant impact on the particle size and structure during the preparation of nanosuspensions [ 18 , 39 , 40 ]. In this investigation, to avoid a blockage of the homogenization gap caused by large particles [ 41 ], the mixed dispersion of pesticide and surfactants was first sheared to reduce the particle size to about 600 nm before passing it into the homogenizer. The effects of both homogenization mode and pressure on the particle size and dispersibility of the chlorantraniliprole nanosuspensions have been explored.…”

Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment of Candidiasis albicans

“…Sample of few drops of nano emulsion was placed on the slide and readings were noted. Measurements were taken at 25 ± 2°C in triplicate manner [ 14 ].…”

“…Before taking the readings, the NE formulations were diluted with distilled water. The readings were taken three times at 25 ± 0.5°C [ 14 ].…”

Pengembangan Preparasi Nanopartikel Thymoquinone-Kitosan Dengan Metode Kosolven Menggunakan Isopropil Alkohol

“…Selain itu thymoquinone juga sulit larut dalam air (Salmani et al, 2014), sehingga diduga mempunyai bioavailabilitas yang kecil (Tubesha et al, 2013). Untuk mengatasi dua masalah tersebut dikembangkan preparat nanopartikel sebagai pembawa thymoquinone.…”