Pengembangan Preparasi Nanopartikel Thymoquinone-Kitosan Dengan Metode Kosolven Menggunakan Isopropil Alkohol

Binarjo, Annas; Yuwono, Tedjo; Priyanti, Renny

doi:10.12928/pharmaciana.v5i2.2363

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Indeks polidispersitas (PI) menunjukkan rentang distribusi ukuran vesikel dan mengetahui terjadinya agregasi. Monodispersi terbentuk jika PI 0,01-0,7 (Binarjo et al, 2015). Jika PI >0,7 maka distribusi ukuran nanopartikel tidak merata serta mudah terjadi aglomerasi.…”

Section: Karakterisasi Fitosom Penentuan Efisiensi Penjerapan Vesikelunclassified

PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT

Akib¹,

Hendra²,

Putri³

et al. 2022

JFSP

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Kersen (Muntingia calabura L.) contains flavonoids that have the potential as antioxidants. However, its hydrophilic characteristics cause poor penetration so that its bioavailability is low. Research had been carried out on the preparation of ethanol extract of cherry leaves in ethosomal vesicle carriers. This study aimed to obtain the optimal phytosome suspension formula. Methods: Sample extraction was carried out by maceration method using ethanol as a solvent and was delipidated was by liquid-liquid method with n-hexane. The characterization of the extract included organoleptic, water-soluble extract content, ethanol soluble extract content, water content, ash content, acid insoluble ash content, and residual solvent. flavonoid contents were carried out by the TLC method and antioxidant activity was determined using DPPH method. Phytosome preparation was prepared by solvent evaporation and thin film hidration with ratio of extract and phosphatidylcholine 1:1 with concentration of 0.5% (A); 1% (B); and 1.5% (C). The characterization included observing morphology of vesicles using optical microscope, determining the size distribution of vesicles using PSA, and calculating the sorption efficiency using a spectrophotometer at max 281 nm. Results: The characteristics of extract were dark green; thick; distinctive aroma; ethanol soluble content were 70.91%; water soluble content were 32.5%; water content were 1.19%; ash content were 1.25%; acid insoluble ash content were 0.49%; and the remaining solvent was 0. The identification of flavonoids showed positive results. The extract has flavonoids and strong antioxidant activity with 62.71 g/mL for IC50. The shape is single layer large vesicle (LUV), diameter was 445.7 nm (A); 420.7 nm (B); and 419.6 nm (C). Vesicle entrapment efficiency was 5.83% (A); 47.575% (B); and 68.81% (C). It can be concluded that the optimal phytosome suspension formula is C with 1.5% phosphatidylcholine and 1.5% of extract.

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Section: Karakterisasi Fitosom Penentuan Efisiensi Penjerapan Vesikelunclassified

PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT

Akib¹,

Hendra²,

Putri³

et al. 2022

JFSP

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“…PI values are from 0.0 to 1.0. The closer to the 0 value, the more homogeneous system is (Binarjo et al, 2015;Patel et al, 2010). Table 2 shows that the PI values of the dispersed SNEDDS of F1, F3, and F6 are smaller than other formulations, indicating better homogeneity of their system than others.…”

Section: Selection Of Snedds Componentsmentioning

confidence: 99%

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system

Pudyastuti¹,

Wijaya²

2022

Pharmaciana

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Kencur (Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility of the extract in water. The purpose of this study was to determine the effect of surfactant combination on the kencur rhizome extract in the SNEDDS system. The SNEDDS formulations were carried out by selecting the surfactant ratio of Tween 80:Span 80 and Tween 80:Chremophor RH 40, followed by selecting the ratio of surfactant mixtures to polyethylene glycol 400 as co-surfactant, and to virgin coconut oil as the oil phase. The clarity, transmittance, emulsification time, particle size, and polydispersity index were evaluated. The stability test was carried out in aquadest, artificial gastric fluid, and artificial intestinal fluid for 4 hours at 37°C. The results showed that the combination of Tween 80: Chremophor RH 40 produced better SNEDDS than Tween 80:Span 80. The combination of surfactant-cosurfactant of Tween 80:Chremophor RH 40:PEG 400 at ratio 3:1 and 1:1 could produce homogenous dispersed SNEDDS showing droplet size of 23,0 and 21,8 nm; transmittance of 95.63% and 93.83%, and SNEDDS preconcentrate emulsified less than 35 seconds. The single surfactant Tween 80:PEG 400 at the ratio 3:1 produce better dispersed SNEDDS than the combined surfactant with droplet size 16.3 nm, transmittance 97.85%, and SNEDDS preconcentrate emulsified less than 45 seconds. The SNEDDS system could produce a smaller droplet size than the extract in aquadest.

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Characterization of Nano Chitosan-Cucumber Suri (Cucumis melo L.) Seeds with Sodium Tripolyphosphate as Crosslinker

Vifta¹,

Luhurningtyas²,

Fajarwati

2019

IOP Conf. Ser.: Mater. Sci. Eng.

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Cucumber suri (Cucumis melo L.) is one of natural materials which has many bioactivities, such as antioxidant, antifungal, antibacterial, anti-cholesterol, antidiabetic, and several other activities. Eventough, Cucumber suri (Cucumis melo L.) has a fairly low flavonoid content. In addition, bioactive compounds in cucumber suri seeds tend to be difficult to dissolve in water, unstable to pH, and even have a low bioavailability. Nanoparticles can be used to increase the activity of natural materials by using chitosan and sodium tripolyphosphate as crosslinking agents. This study aims to determine the characteristics of nano chitosan-cucumber suri seeds (Cucumis melo L.). First, Cucumber Suri seeds weas previously extracted using maceration method and identified theirs bioactive compounds. And then, Cucumber Suri seed extract was encapsulated with Chitosan: STPP (5: 1). Characterization test was carried out using UV-Vis Spectrophotometry, Infrared Spectrophotometry, and Particle Size Analyzer (PSA). The encapsulation process of Cucumber Suri seed extract produces a clear, homogeneous and stable supernatant. The values of characterization with UV-Vis Spectrophotometry in 0 to 60 minutes was >90%, that indicated nanosized particleswas succefully formed. The IR characterization values indicate a shift in the nano chitosan-cucumber suri seeds wavelength compare with chitosan. The shift of –OH stretching vibration at wavelength 3403 cm−1 and stretching vibration of C=O in 1642 cm−1 showed there was an interaction between chitosan and Cucumber Suri seed extract. Analysis using Particle Size Analyzer (PSA) showed that chitosan-cucumber suri seeds had a normal polydispersion index (PI) of 0.677 and average particle diameter size was 360 nm.

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Pengembangan Preparasi Nanopartikel Thymoquinone-Kitosan Dengan Metode Kosolven Menggunakan Isopropil Alkohol

Cited by 3 publications

References 13 publications

PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT

PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system

Characterization of Nano Chitosan-Cucumber Suri (Cucumis melo L.) Seeds with Sodium Tripolyphosphate as Crosslinker

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