Characterization method for calculating diffusion coefficient of drug from polylactic acid (PLA) microneedles into the skin

Wu, Libo; Shrestha, Pranav; Iapichino, Martina; Cai, Yicheng; Kim, Beomjoon; Stoeber, Boris

doi:10.1016/j.jddst.2020.102192

Cited by 30 publications

(15 citation statements)

References 33 publications

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“…Polymers are the most promising materials for manufacturing MNs. At present, a range of techniques has been reported to fabricate polymer MNs, such as drawing lithography, [124][125][126] micromolding, [127,128] 3D printing, [129] and droplet-born air blowing [130] (Figure 6). The characteristics of different fabrication methods are summarized in Table 6.…”

Section: Manufacturing Methods For Polymer Mnsmentioning

confidence: 99%

“…The encapsulated drugs in MNs with cross‐linked polymer as MNs matrix can be released after absorbing interstitial fluid, and show a relative slower drug release rate. [ 112 ] Biodegradable polymers, such as PLGA, [ 113,114 ] PLA, [ 115 ] and PCL, [ 116 ] also can used as the matrix materials for MNs. They cannot be dissolved or swelled in water.…”

Section: Materials and Classification Of Mnsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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Section: Manufacturing Methods For Polymer Mnsmentioning

confidence: 99%

Section: Materials and Classification Of Mnsmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…According to Darcy's law, the permeability coefficient ( k ) relates pressure gradient to mass flux according to Equation (20) [ 287 ]:

where Q, μ, L, A, and ΔP represent flow rate, the dynamic viscosity of the fluid, sample length, cross-section area, and pressure drop within the scaffold, respectively. Based on Fick's first law, the diffusivity also relates diffusion flux to the concentration gradient according to Equation (21) [ 288 ].

where D is the diffusion coefficient of penetrant and

represents the concentration gradient along the x -direction.…”

Section: Characterization Of Additively Manufactured Implantsmentioning

confidence: 99%

Additively manufactured metallic biomaterials

Davoodi

Montazerian

Mirhakimi

et al. 2022

Bioactive Materials

107

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“…The variety of polymers used for the fabrication of MNs are polylactide-co-glycolide acid (PLGA) [ 66 ], poly-L-lactic acid (PLA) [ 67 ], polycaprolactone (PCL) [ 68 ], poly-glycolic acid (PGA) [ 69 ], hyaluronic acids (HA) [ 70 ], polyvinyl pyrrolidone (PVP) [ 71 ], polyvinyl alcohol (PVA) [ 72 ], fibroin [ 73 ], sodium alginate [ 74 ], chitosan [ 75 ], carboxymethyl cellulose (CMC) [ 76 ] and more [ 64 ].…”

Section: Materials Used For Fabrication Of Mnsmentioning

confidence: 99%

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Kulkarni¹,

Damiri

Rojekar

et al. 2022

Pharmaceutics

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Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology due to its multifaceted and broad-spectrum applications. This review broadly discusses MN’s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.

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Characterization method for calculating diffusion coefficient of drug from polylactic acid (PLA) microneedles into the skin

Cited by 30 publications

References 33 publications

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Additively manufactured metallic biomaterials

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

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