Characterization of a homologous series of  d , l -lactic acid oligomers; a mechanistic study on the degradation kinetics in vitro

Schliecker, Gesine; Schmidt, Carsten; Fuchs, Stefan; Kissel, Thomas

doi:10.1016/s0142-9612(03)00243-6

Cited by 187 publications

(147 citation statements)

References 34 publications

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“…(Vert et al, 1994;Prokop and Davidson, 2008;Danhier et al, 2012). Lactic acid is more hydrophobic than glycolic acid and, thus, lactide-rich PLGA copolymers are less hydrophilic, absorb less water, and consequently, degrade more gradually (Park, 1994;Schliecker et al, 2003;Dinarvand et al, 2011).…”

Section: Properties Of Plgamentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

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Section: Properties Of Plgamentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

View full text Add to dashboard Cite

“…Examples of such polymers are polylactide, polyglycolide, polylactide-coglycolide, polyhydroxybutyrate, hyaluronic acid, polycaprolactone, polyortho ester (Pan et al, 2006;Raval et al, 2007). The property by which these polymers undergo hydrolytic and enzymatic degradation when exposed to biological fluid makes them potential candidates for controlled drug delivery where polymer can be degraded, absorbed or excreted from a biological environment (Schliecker et al, 2003;Sun et al, 2006). Thus, drug release from these systems can be achieved by: (1) diffusion of drug from the polymeric matrix, (2) dissolution of drug into the release medium; and (3) biodegradation of polymeric chains.…”

Section: Mechanisms Of Drug Release Kinetics For Coronary Stentsmentioning

confidence: 99%

Mechanism of controlled release kinetics from medical devices

Raval

Parikh

2010

Braz. J. Chem. Eng.

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-Utilization of biodegradable polymers for controlled drug delivery has gained immense attention in the pharmaceutical and medical device industry to administer various drugs, proteins and other biomolecules both systematically and locally to cure several diseases. The efficacy and toxicity of this local therapeutics depends upon drug release kinetics, which will further decide drug deposition, distribution, and retention at the target site. Drug Eluting Stent (DES) presently possesses clinical importance as an alternative to Coronary Artery Bypass Grafting due to the ease of the procedure and comparable safety and efficacy. Many models have been developed to describe the drug delivery from polymeric carriers based on the different mechanisms which control the release phenomenon from DES. Advanced characterization techniques facilitate an understanding of the complexities behind design and related drug release behavior of drug eluting stents, which aids in the development of improved future drug eluting systems. This review discusses different drug release mechanisms, engineering principles, mathematical models and current trends that are proposed for drug-polymer coated medical devices such as cardiovascular stents and different analytical methods currently utilized to probe diverse characteristics of drug eluting devices.

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“…The different polymers are simulated by performing 99 random scissions on initial chains of 55556, 166667, or 500000 units. Chains containing less than 12 units are considered to be water soluble [7] and are not included in the calculation of molecular weight. The results for M n reduction and M w reduction are given in table 1 and table 2 …”

Section: Case Study 2: the Effect Of Random And End Scissionmentioning

confidence: 99%

“…In chain end scission, the final bond in a chain is cleaved resulting in the production of a monomer. The final bond may be more susceptible to hydrolysis because of its proximity to the acidic chain end which may catalyse the hydrolysis reaction [7,8]. Given a typical polymer chain may consist of several thousand bonds, a large number of end scissions may be required per chain in order for the reduction in chain length to be comparable to a single random scission.…”

Section: Introductionmentioning

confidence: 99%

Computer Simulation of Polymer Chain Scission in Biodegradable Polymers

Gleadall¹

2013

J Biotechnol Biomater

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Biodegradable polymers degrade due to the hydrolysis (chain scission) of the polymer chains. Two theories of hydrolysis are that 1) scissions occur randomly at any bond in chains, and 2) scissions occur in the final bond at chain ends. In this study, a simulation tool was developed to simulate both random chain scission and chain end scission. The effect of each type of scission was analysed. Random scissions were found to have over 1000 time's greater impact on molecular weight reduction than end scissions. For the degradation of poly lactic acid by random scission, it was found that M n must reduce to <5000 g/mol in order for a polymer to exhibit significant mass loss due to the diffusion of water-soluble short chains. In contrast, end scission was able to produce a significant fraction of water-soluble chains with little or no effect on M n . The production rate of water-soluble chains was linearly related to end scission but increase in an accelerated manner due to random scission. Molecular weight distributions were fitted to experimental data for the degradation of poly D-lactic acid.

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Characterization of a homologous series of d , l -lactic acid oligomers; a mechanistic study on the degradation kinetics in vitro

Cited by 187 publications

References 34 publications

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mechanism of controlled release kinetics from medical devices

Computer Simulation of Polymer Chain Scission in Biodegradable Polymers

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