Characterization of Brain-Targeted Drug Delivery Enhanced by a Combination of Lipid-Based Microbubbles and Non-Focused Ultrasound

Omata, Daiki; Hagiwara, Fumiko; Munakata, Lisa; Shima, Tadamitsu; Kageyama, Saori; Suzuki, Yachiyo; Azuma, Takashi; Takagi, Shu; Seki, Kazuhiko; Maruyama, Kazuo; Suzuki, Ryo

doi:10.1016/j.xphs.2020.06.008

Cited by 14 publications

(9 citation statements)

References 34 publications

(39 reference statements)

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“…MRI-guided Low-Intensity Focused Ultrasound improved Trastuzumab administration to Her2-positive brain-metastatic breast cancer cells (45).Non-Low Intensity Focused Ultrasound and microbubble medication delivery have been beneficial (46).In an investigation, low-Intensity Focused Ultrasound enhanced gene vector transport to the brain, indicating future implications for clinical trials of CNS gene therapy (47). Low-Intensity Focused Ultrasound improves medicine delivery to Parkinson's patients (48).…”

Section: High-intensity Low Intensity Focused Ultrasound (Hifu) For M...mentioning

confidence: 99%

MRI-guided Focused Ultrasound Neuromodulation, Review Article

Ahmadi¹,

Anvarinia²

2022

Int. J. Res. Publ. Rev.

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MRI-guided Low Intensity Focused Ultrasound is superior to other minimally invasive neuromodulation procedures in terms of spatial resolution and activating deeper brain areas. Parkinson's, Alzheimer's, essential tremor, brain cancer, epilepsy, nerve block, medicine administration, and stroke benefit from MRI-guided LFUS. This minimally invasive neurostimulation approach is also safe . Future clinical trials should focus on Focused Ultrasound for neurologic diseases. MRI-guided Low Intensity Focused Ultrasound is a new modality for performing incision-less neurosurgical procedures such as thermoablation. According to emerging evidence, low-intensity can also be used for neuromodulation with several advantages, including high spatial precision and targeting deep brain regions. We review the existing data on the biological mechanisms of MRI-guided Focused Ultrasound, neuronal activity emerging indications for neuromodulation, and the strengths and limitations of this approach.

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Section: High-intensity Low Intensity Focused Ultrasound (Hifu) For M...mentioning

confidence: 99%

MRI-guided Focused Ultrasound Neuromodulation, Review Article

Ahmadi¹,

Anvarinia²

2022

Int. J. Res. Publ. Rev.

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“…In the brain, blood-brain barrier restricts the transportation of molecules between the blood and brain parenchyma. The endothelial cells in the brain have a tight junction, and the interaction of pericytes and astrocytes resulted in no transportation of most drugs except low molecular weight and high hydrophobicity drugs 33,34) (Fig. 2A).…”

Section: Blood-brain Barrier Openingmentioning

confidence: 99%

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Omata

Munakata

Maruyama

et al. 2021

Biological & Pharmaceutical Bulletin

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Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can induce mechanical effects derived from microbubbles behaviors such as an expansion, contraction, and collapse depending on ultrasound conditions. These mechanical effects induce several biological effects, including enhancement of vascular permeability.For drug delivery, one promising approach is enhancing vascular permeability using ultrasound and microbubbles, resulting in improved drug transport to targeted tissues. This approach is applied to several tissues and drugs to cure diseases. This review describes the enhancement of vascular permeability by ultrasound and microbubbles and its therapeutic application, including our recent study. We also discuss the current situation of the field and its potential future perspectives.

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“…For example, in a recent investigation, a mixture of lipid-coated microbubbles and propidium iodide (PI) was utilized for USMB-mediated delivery of PI into endothelial cells cultured in microfluidic channels [136]. In another study, mixtures of microbubbles and evans blue dye/fluorescent-dextran were used to study USMB-mediated drug delivery to the brain in mice [137]. A mixture of commercial SonoVue microbubbles and enhanced green fluorescent protein plasmid (pEGFP)were used to study USMB-assisted gene transfection in prostate cancer cells in vitro and in vivo in a recent investigation [138].…”

Section: Co-administration Of Cargo and Microbubblesmentioning

confidence: 99%

Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities

et al. 2021

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Acute respiratory distress syndrome (ARDS) is characterized by increased permeability of the alveolar–capillary membrane, a thin barrier composed of adjacent monolayers of alveolar epithelial and lung microvascular endothelial cells. This results in pulmonary edema and severe hypoxemia and is a common cause of death after both viral (e.g., SARS-CoV-2) and bacterial pneumonia. The involvement of the lung in ARDS is notoriously heterogeneous, with consolidated and edematous lung abutting aerated, less injured regions. This makes treatment difficult, as most therapeutic approaches preferentially affect the normal lung regions or are distributed indiscriminately to other organs. In this review, we describe the use of thoracic ultrasound and microbubbles (USMB) to deliver therapeutic cargo (drugs, genes) preferentially to severely injured areas of the lung and in particular to the lung endothelium. While USMB has been explored in other organs, it has been under-appreciated in the treatment of lung injury since ultrasound energy is scattered by air. However, this limitation can be harnessed to direct therapy specifically to severely injured lungs. We explore the cellular mechanisms governing USMB and describe various permutations of cargo administration. Lastly, we discuss both the challenges and potential opportunities presented by USMB in the lung as a tool for both therapy and research.

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Characterization of Brain-Targeted Drug Delivery Enhanced by a Combination of Lipid-Based Microbubbles and Non-Focused Ultrasound

Cited by 14 publications

References 34 publications

MRI-guided Focused Ultrasound Neuromodulation, Review Article

MRI-guided Focused Ultrasound Neuromodulation, Review Article

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities

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