Characterization of carvacrol beta-cyclodextrin inclusion complexes as delivery systems for antibacterial and antioxidant applications

Santos, Emerson H.; Kamimura, Juliane A.; Hill, Laura E.; Gomes, Carmen

doi:10.1016/j.lwt.2014.08.046

Cited by 142 publications

(89 citation statements)

References 45 publications

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“…72 The TEM images of carvacrol b-CD inclusion complexes showed agglomeration where larger particles appeared to attract smaller particles. 65 Another study of TEM imaging of empty and Zataria multiflora EO loaded chitosan nanoencapsules showed nearly spherical shape and smooth surface. 55 Further, the study concludes that loading of EO on chitosan nanoencapsules leads to increased particle size of the formulations.…”

Section: Microscopic Imagingmentioning

confidence: 99%

“…55,65,72,134 However, analysis of the particle size and surface charge of formulation usually carried out by dynamic laser scattering technique coupled with Zeta Potential analyzer. 30,33,55,134 SEM analysis facilitates the study of surface morphology of the encapsulated material while TEM helps in the exploration of micro-structural features and thickness of wall material.…”

Section: Microscopic Imagingmentioning

confidence: 99%

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Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms

et al. 2016

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Natural polymer based encapsulation of essential oil (EO) is one of the emerging and challenging area of research in perfumery, cosmetics, flavoring agents, preservatives, therapeutics, etc. The knowledge of formulation techniques and physico-chemical properties of the polymers are the basic requirements for the successful encapsulations of essential oils (EOs). This current review article is focused on a comparative account of various formulation techniques based on their applicability. For the first time, it also reviews various physico-chemical techniques used in the analysis of EO encapsulates to determine their stability, structure, surface morphology, and encapsulation efficiency. Further, the mechanisms involved in the release of EOs from encapsulates, along with various factors affecting their release, have also been discussed.

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Section: Microscopic Imagingmentioning

confidence: 99%

Section: Microscopic Imagingmentioning

confidence: 99%

Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms

et al. 2016

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“…In the food area, cyclodextrins are nontoxic and considered GRAS, and thus are used for several purposes [120,121]. These structures offer increased resistance to degradation of the active compounds and make the host-microcapsule complex more stable [53,56,57,122,123].…”

Section: Cyclodextrinsmentioning

confidence: 99%

β-Cyclodextrins as Encapsulating Agents of Essential Oils

Capelezzo¹,

Mohr²,

Dalcanton³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Many scientific studies have made advances in the ability to encapsulate natural extracts by cyclodextrins. These studies have addressed the physical and chemical conditions of the encapsulation reactions, employed several types of essential oils and characterized the microcapsules as to their ability to release encapsulated active principles. The essential oils studies with cyclodextrin encapsulation processes have been highly varied. However, the most studied are the essential oils with antimicrobial and antioxidant capacities. The essential antimicrobial and antioxidant oils are easily degraded. In the presence of oxygen, they are oxidized, and at low temperatures, they are volatilized and decomposed. Thus, cyclodextrins are coatings capable of protecting these essential oils from environmental conditions and agents capable of promoting oil degradation, in addition to controlling their release. In this chapter of the book, we review scientific papers that examine the encapsulation of antimicrobial essential oils and antioxidant essential oils with β-cyclodextrins.

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“…30 Similar observations have been made by others. [31][32][33] A study by Neoh and colleagues demonstrated improved aqueous solubility of 10-undecyn-1-ol through formation of an inclusion complex with meth--CD. 34 An increase in the amount of dissolved meth--CD improved the inhibition e®ect of 10-undecyn-1-ol on the mycelial growth of the fungus.…”

Section: Cyclodextrins Loaded With Natural Productsmentioning

confidence: 99%

Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

Wong

Dolzhenko

Lee

et al. 2017

J. Mol. Eng. Mater.

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Antimicrobial resistance poses one of the most serious global challenges of our age. Cyclodextrins (CDs) are widely utilized excipients in formulations because of their solubilizing properties, low toxicity, and low in°ammatory response. This review summarizes recent investigations of antimicrobial agents involving CDs and CD-based antimicrobial materials. CDs have been employed for antimicrobial applications either through formation of inclusion complexes or by chemical modi¯cation of their hydroxyl groups to tailor pharmaceutically active compounds. Applications of these CD inclusion complexes include drug delivery, antimicrobial coatings on materials (e.g., biomedical devices and implants) and antimicrobial dressings that help to prevent wound infections. There are relatively limited studies of chemically modi¯ed CDs with antimicrobial activity. The mechanism of action of antimicrobial CD inclusion complexes and derivatives needs further elucidation, but activity of CDs and their derivatives is often associated with their interaction with bacterial cell membranes.

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Characterization of carvacrol beta-cyclodextrin inclusion complexes as delivery systems for antibacterial and antioxidant applications

Cited by 142 publications

References 45 publications

Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms

Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms

β-Cyclodextrins as Encapsulating Agents of Essential Oils

Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

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