Dendrimers have attracted
immense interest in science and technology
due to their unique chemical structure that offers a myriad of opportunities
for researchers. Dendritic design allows us to present peptides in
a branched three-dimensional fashion that eventually leads to a globular
shape, thus mimicking globular proteins. Peptide dendrimers, unlike
other classes of dendrimers, have immense applications in biomedical
research due to their biological origin. The diversity of potential
building blocks and innumerable possibilities for design, along with
the fact that the area is relatively underexplored, make peptide dendrimers
sought-after candidates for various applications. This review summarizes
the stepwise evolution of peptidic dendrimers along with their multifaceted
applications in various fields. Further, the introduction of biomacromolecules
such as proteins to a dendritic scaffold, resulting in complex macromolecules
with discrete molecular weights, is an altogether new addition to
the area of organic chemistry. The synthesis of highly complex and
fully folded biomacromolecules on a dendritic scaffold requires expertise
in synthetic organic chemistry and biology. Presently, there are only
a handful of examples of protein dendrimers; we believe that these
limited examples will fuel further research in this area.
Natural polymer based encapsulation of essential oil (EO) is one of the emerging and challenging area of research in perfumery, cosmetics, flavoring agents, preservatives, therapeutics, etc. The knowledge of formulation techniques and physico-chemical properties of the polymers are the basic requirements for the successful encapsulations of essential oils (EOs). This current review article is focused on a comparative account of various formulation techniques based on their applicability. For the first time, it also reviews various physico-chemical techniques used in the analysis of EO encapsulates to determine their stability, structure, surface morphology, and encapsulation efficiency. Further, the mechanisms involved in the release of EOs from encapsulates, along with various factors affecting their release, have also been discussed.
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