Characterization of collagenolytic activity in the ulcerating cornea

Berman, Michael B.; Dohlman, Claes H.; Gnädinger, M.C.; Davison, Peter F.

doi:10.1016/s0014-4835(71)80030-1

Cited by 49 publications

(11 citation statements)

References 5 publications

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“…Berman et al (1971) showed the production of collagenases in rabbit eyes, and subsequently (Berman et al, 1973a) in human material. These enzymes cleave the tropocollagen molecule into two components containing threequarters and one-quarter of the original molecule respectively.…”

Section: Casementioning

confidence: 99%

Ulceration of the cornea in rheumatoid arthritis.

Jayson¹,

Easty²

1977

Annals of the Rheumatic Diseases

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SUMMARY Five patients with melting of the cornea in association with rheumatoid arthritis are described. The arthritis was often inactive and without systemic manifestations, in contrast to that seen in association with scleritis. In 3 there was evidence of reduced tear formation, but in none was tear production absent. In 3 patients the lesions healed during treatment with azathioprine or penicillamine.

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Section: Casementioning

confidence: 99%

Ulceration of the cornea in rheumatoid arthritis.

Jayson¹,

Easty²

1977

Annals of the Rheumatic Diseases

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“…The tear film proteases have previously been evaluated in both normal and diseased eyes of animals and humans 4–16 . In ulcerated horse corneas, tear film levels of MMP2, MMP9 (also called gelatinase A and B, respectively) and neutrophil elastase are significantly elevated when compared to age‐matched normal controls 6 and are hypothesized to contribute to the breakdown of stromal collagen 6 .…”

Section: Introductionmentioning

confidence: 99%

Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis

Ollivier¹,

Brooks²,

Setten

et al. 2004

Veterinary Ophthalmology

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Ulcerative keratitis in horses is associated with initially high levels of tear film proteolytic activity that decrease as the ulcers heal. The success of medical and surgical treatment of the corneal ulcers is reflected by the enzyme activity in tears. In horses successful treatment does lead to a rapid reduction in tear film proteolytic activity that corresponded with the improvement in the clinical signs of corneal ulceration. Measurement of MMP activity in the tear film might represent a way to monitor the progression of corneal healing in horses with ulcerative keratitis.

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“…[1][2][3] Although there are more than a dozen matrix metalloproteinases (MMPs) that can dissolve collagen and other tissues (Table 1), this review is primarily concerned with MMP-9 (also called gelatinase-B). [1][2][3] Although there are more than a dozen matrix metalloproteinases (MMPs) that can dissolve collagen and other tissues (Table 1), this review is primarily concerned with MMP-9 (also called gelatinase-B).…”

mentioning

confidence: 99%

The Practical Detection of MMP-9 Diagnoses Ocular Surface Disease and May Help Prevent Its Complications

Kaufman

2013

Cornea

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A rapid in-office test that is sensitive for identifying inflammatory dry eye and ocular surface disease may facilitate better preoperative management of the ocular surface. Optimization of the ocular surface perioperatively would be expected to reduce complications from laser in situ keratomileusis and other surgeries that often make the underlying disease worse. This test may also indicate the need for antiinflammatory therapies, such as cyclosporine or steroids, and also may predict those patients who are more likely to respond.

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Characterization of collagenolytic activity in the ulcerating cornea

Cited by 49 publications

References 5 publications

Ulceration of the cornea in rheumatoid arthritis.

Ulceration of the cornea in rheumatoid arthritis.

Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis

The Practical Detection of MMP-9 Diagnoses Ocular Surface Disease and May Help Prevent Its Complications

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