1997
DOI: 10.1016/s0006-3495(97)78922-7
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Characterization of electric-pulse-induced permeabilization of porcine skin using surface electrodes

Abstract: We measured the transient and long-term changes of permeability of full-thickness porcine skin after the application of a single or a train of electric pulses, as the basis for optimization of the electrical parameters for enhancing transdermal drug or gene delivery by electroporation. Two electrodes were attached to the stratum corneum of excised skin for transdermal electric pulse delivery and impedance measurement. Both transient and long-term permeabilization were found to be dependent on the electrical ex… Show more

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Cited by 47 publications
(35 citation statements)
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“…1 Recently, this method has been applied to permeate the upper layer (stratum corneum) of the skin for the purpose of drug and gene delivery. 2,3 The possibility of applying surface…”
Section: Introductionmentioning
confidence: 99%
“…1 Recently, this method has been applied to permeate the upper layer (stratum corneum) of the skin for the purpose of drug and gene delivery. 2,3 The possibility of applying surface…”
Section: Introductionmentioning
confidence: 99%
“…In human cadaver skin, ultrasound enhanced transdermal drug delivery without causing damage to the skin or underlying tissue or altering the permeability properties of the epidermis. 16 In summary, ultrasound is a promising new and safe method for enhancing the efficiency of systemic gene delivery to tumor endothelium. The ultrasound technology used in this study was off-the-shelf technology with no special power supplies or specially designed probes.…”
Section: Discussionmentioning
confidence: 99%
“…15,16 Ultrasound-mediated delivery is potentially a powerful new method for enhancing the delivery of therapeutic compounds. Ultrasound-enhanced delivery to cells has been demonstrated in vitro by uptake of extracellular fluid, drugs, and DNA into cells.…”
Section: Introductionmentioning
confidence: 99%
“…We got the electrical conductivity values and their changes during electroporation from literature and experiments, as well as the electric field values above which tissues are permeabilized. [4][5][6][7][15][16][17][18]25,26 However, getting these values was a difficult task, due to the lack of measurements in this field.…”
Section: Parameters Of the Numerical Modelmentioning
confidence: 99%