Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes

Shibahara, Takeshi; Wilcox, Josiah N.; Couse, Tracey L.; Madara, James L.

doi:10.1053/gast.2001.20904

Cited by 101 publications

(72 citation statements)

References 48 publications

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“…Under physiological conditions, virtually all lamina propria and intraepithelial lymphocytes express CXCR3, and this expression can be significantly increased in vitro by IFN-␥ (46,169). In the same studies, CXCR3 ligands, IP-10, and Mig were shown to be expressed on intestinal cells in vitro after IFN-␥ treatment, and antibodies to these chemokines blocked intraepithelial lymphocyte chemotaxis in epithelial cell-conditioned medium.…”

Section: Produced By Dendritic Cells That Attracts T Cells and Naturamentioning

confidence: 81%

Chemokines and chemokine receptors in leukocyte trafficking

Olson

Ley

2002

American Journal of Physiology-Regulatory, Integrative and Comp

588

445

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mokines regulate inflammation, leukocyte trafficking, and immune cell differentiation. The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is probably the best understood of these processes, and information on chemokines in inflammation, asthma, and neurological diseases is rapidly increasing. Over the past 15 years, understanding of the size and functional complexity of the chemokine family of peptide chemoattractants has grown substantially. In this review, we first present information regarding the structure, expression, and signaling properties of chemokines and their receptors. The second part is a systems physiology-based overview of the roles that chemokines play in tissue-specific homing of lymphocyte subsets and in trafficking of inflammatory cells. This review draws on recent experimental findings as well as current models proposed by experts in the chemokine field.

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Section: Produced By Dendritic Cells That Attracts T Cells and Naturamentioning

confidence: 81%

Chemokines and chemokine receptors in leukocyte trafficking

Olson

Ley

2002

American Journal of Physiology-Regulatory, Integrative and Comp

588

445

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“…In graft versus host disease-associated intestinal inflammation, or upon intestinal bacterial infection, IEL express a high level of the integrin α Xβ 2 (Huleatt et al 1995). The expression of this integrin has been linked to that of α E β 7, which may be upregulated by epithelial-derived TGFβ (Shibahara et al 2000(Shibahara et al , 2001. Recent studies have found that CD8+ lymphocyte adhesion to epithelial cells via α E β 7 contributes to the destruction of pancreatic islet cells (Butcher et al 1996, Feng et al 2002.…”

mentioning

confidence: 99%

Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

2005

Mem. Inst. Oswaldo Cruz

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“…The chemokines lead to paracrine and autocrine activation of surrounding cells in addition to chemoattraction of lymphocytes, neutrophils, monocytes, macrophages, and dendritic cells (25)(26)(27). During inflammation, enterocytes are bathed in a cytokine-rich milieu that can enhance both their innate defense capacity and their ability to interact with and influence local leukocyte populations.…”

mentioning

confidence: 99%

Lamina Propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Proinflammatory Response Against an Intracellular Pathogen

Mennechet

Kasper

Rachinel

et al. 2002

The Journal of Immunology

103

105

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Acute and lethal ileitis can be elicited in certain strains of inbred mice after oral infection with the intracellular protozoan parasite Toxoplasma gondii. The development of this inflammatory process is dependent upon the induction of a robust Th1 response, including overproduction of IFN-γ, TNF-α, and NO, as has been reported in other experimental models of human inflammatory bowel disease. In this study we have investigated the role of CD4+ T cells from the lamina propria (LP) in the early inflammatory events after T. gondii infection using isolated and primary cultured intestinal cells from infected mice and immortalized mouse mICcl2 intestinal epithelial cells. Primed LP CD4+ T cells isolated from parasite-infected mice produce substantial quantities of both IFN-γ and TNF-α. IFN-γ- and TNF-α-producing LP CD4+ T cells synergize with infected mICcl2 and enhance the production of several inflammatory chemokines including macrophage-inflammatory protein-2, monocyte chemoattractant protein-1, monocyte chemoattractant protein-3, macrophage-inflammatory protein-1αβ, and IFN-γ-inducible protein-10. Furthermore, primed LP CD4+ T cells cocultured with infected mICcl2 inhibited replication of the parasite in the intestinal epithelial cells. Thus, LP CD4+ T cells can interact with parasite-infected intestinal epithelial cells and alter the expression of several proinflammatory products that have been associated with the development of intestinal inflammation. The interaction between these two components of the gut mucosal compartment (CD4+ T cells and enterocytes) may play a role in the immunopathogenesis of this pathogen-driven experimental inflammatory bowel disease model.

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Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes

Cited by 101 publications

References 48 publications

Chemokines and chemokine receptors in leukocyte trafficking

Chemokines and chemokine receptors in leukocyte trafficking

Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

Lamina Propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Proinflammatory Response Against an Intracellular Pathogen

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