Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions

Lee, Yoong; Hahm, Yeong-Min; Matsuya, Shigeki; Nakagawa, Masaharu; Ishikawa, Kunio

doi:10.1007/s10853-007-1629-3

Cited by 49 publications

(39 citation statements)

References 26 publications

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“…PO 4 3-required for formation of apatite layer are only supplied from the surrounding SBF in accordance with [43][44][45]. Similar CO 3 HA formation has been observed by various research groups [31,46]. In our case, the inclusion of CO 3 2-is considered to produce an apatite more similar to that found in natural bone in terms of composition and structure [47].…”

Section: Ftir Of the Synthesized G-cps/w Hybridssupporting

confidence: 82%

Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

et al. 2010

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Biohybrids consisting of gelatin (G) and calcium phosphate silicate/wollastonite (CPS/W) have not been prepared so far. In this work our results are focused on the possibility of obtaining G-CPS/W bioactive hybrids in vitro. XRD, FTIR, SEM/EDS techniques were employed to characterize the synthesized hybrid materials. FTIR shows that before immersion in 1.5 SBF the "red shift" of COO -band for pure G is observed. The presence of this bond could be attributed to the formation of COO-Ca 2+ via non-biomimetic route. After immersion in 1.5 SBF, FTIR shows the presence of A-and B-type carbonate containing hydroxyapatite (A/B-CO 3 HA) . ESD and FTIR show that small amount of calcite (CaCO 3 ) are present after in vitro test in 1.5 SBF for 3 days. XRD reveals that CO 3 HA and small amounts of CaCO 3 can be detected after in vitro test. SEM results obtained for immersed samples show that hydroxyapatite (HA) particles fully covered the surface of the hybrids by a layer composed of spherulites. At higher magnification, very small elongated crystallites could be observed. Sp. z o.o. © Versita

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Section: Ftir Of the Synthesized G-cps/w Hybridssupporting

confidence: 82%

Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

et al. 2010

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“…Consequently, it has been sidelined by carbonate-free HAp, which has been used as a bone substitute material for a long time 4) . Previously, we reported that low crystalline CO3Ap blocks could be fabricated based on phase transformation by dissolution-precipitation reaction using suitable calcium-containing metastable phase as a precursor, since CO3Ap is the most stable phase thermodynamically in an aqueous solution at neutral and alkaline regions [5][6][7] . For example, calcite block transformed to CO3Ap block retaining its original shape, when the calcite block was immersed in phosphate salt solution 8,9) .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

et al. 2011

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Carbonate apatite (CO3Ap) foam may be an ideal bone substitute as it is sidelined to cancellous bone with respect to its chemical composition and structure. However, CO3Ap foam fabricated using -tricalcium phosphate foam showed limited mechanical strength. In the present study, feasibility of the fabrication of calcite which could be a precursor of CO3Ap was studied. Calcite foam was successfully fabricated by the so-called "ceramic foam" method using calcium hydroxide coated polyurethane foam under CO2+O2 atmosphere. Then the calcite foam was immersed in Na2HPO4 aqueous solution for phase transformation based on dissolutionprecipitation reaction. When CaO-free calcite foam was immersed in Na2HPO4 solution, low-crystalline CO3Ap foam with 93-96% porosity and fully interconnected porous structure was fabricated. The compressive strength of the foam was 25.6±6 kPa. In light of these results, we concluded that the properties of the precursor foam were key factors for the fabrication of CO3Ap foams.

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“…The small bands at 1553 (1554) cm -1 suggest there may be another crystallographically distinct CO 3 2-site, perhaps associated with the CO 3 2-replacement of OH -(A-type substitution) as suggested by [48]. This observation showed that the CO 3 HA formed on the synthesized samples contained both A-type and B-type CO 3 2-ions [51]. The presented FTIR spectra are in good agreement with other bioactive ceramics [52].…”

Section: Resultsmentioning

confidence: 56%

Sol-gel bioactive glass-ceramics Part II: Glass-ceramics in the CaO-SiO2-P2O5-MgO system

et al. 2009

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Ceramics, with basic composition based on the CaO-SiO 2 -P 2 O 5 -MgO system with different Ca+ Mg/P+Si molar ratio (R), were prepared via polystep sol-gel technique. The structure of the obtained ceramic materials has been studied by XRD, FTIR spectroscopy, and SEM. X-ray diffraction showed the presence of akermanite and HA for the sample with R = 1.68 and Mg substituted β-TCP and silicocarnotite for the sample with R = 2.16, after thermal treatment at 1200°C/2 h. The obtained results are in good agreement with FTIR. In vitro test for bioactivity in static condition proved that the carbonate containing hydroxyapatite (CO 3 HA) can be formed on the surface of the synthesized samples. CO 3 HA consisted of both A-and B-type CO 3 2-ions. SEM micrographs depicted different forms of HA particles, precipitated on the surface after soaking in 1.5 simulated body fluid (SBF). Warsaw and Springer-Verlag Berlin Heidelberg. © Versita

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Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions

Cited by 49 publications

References 26 publications

Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

Sol-gel bioactive glass-ceramics Part II: Glass-ceramics in the CaO-SiO2-P2O5-MgO system

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