Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap. epidermidis Isolated from Acne

Abstract

In this study, three different self emulsifying drug delivery systems of rifampicin (SEDD-R) were made using oleic acid and different surfactants such as Tween 80, Chremophor RH 40 and Chremophor EL designated as RN-TW, RN-CRH and RN-CEL. These self-emulsifying systems were converted to rifampicin nanoemulsion by adding water under sonication. The resulting particle sizes were found to be 192. Antibacterial effect of the preparations was evaluated against S. epidermidis and S. aureus isolated from acne and showed effective results.

Topical Nanoemulsion of Rifampicin with Benzoic Acid and Salicylic Acid: Activity Against Staphylococcus aureus, Stap. epidermis and Candida albicans

“…F1 (1% rifampicin) nanoemulsions showed significant results against AC1, AC3, S. aureus (ATCC 25923) and S. epidermis (ATCC 12228) strains, but had no effect on C. albicans. This reconfirms that the nanoemulsion containing rifampicin is a promising agent for targeting acne due to increased bacterial resistance to conventional topical antibiotic preparations (Begum et al, 2015b). Only F7 and F4 nanoemulsions displayed positive results against the bacterial strains and C. albicans.…”

“…Nanoemulsions were prepared by sonication method with some modifications (Begum et al, 2015b). Eight nanoemulsions consisting of different combinations of rifampicin (1%), benzoic acid (6%) and salicylic acid (3%) were formulated using oleic acid, Tween 80 and water.…”

“…Drug content, entrapment efficiency; in vitro drug release, pH stability and antibiotic sensitivity studies were performed for both delivery systems. The results for SEDD-R were comparatively better than that for rifampicin niosomes (Begum et al, 2015a;Begum et al, 2015b). Hence, nanoemulsion was selected as the mode of delivery for this study.…”

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

“…In order to increase the purity of liposomal solution (e.g., removing titanium particles formed during sonication) of the liposomal solution, samples were centrifuged at 5000 rpm for 5 minutes. For the separation of larger particles from smaller particles and homogenization of the resulting suspension, a 0.45 µm lter was used, while for sterilizing the resultant suspension, a 0.22 µm lter was utilized (13).…”