Nanoliposomal system of rosemary essential oil made by specific human cell phospholipids and evaluation of its anti-cancer properties

Salari, Shahrzad; Salari, Reza

doi:10.1007/s13204-019-01009-1

Cited by 16 publications

(8 citation statements)

References 16 publications

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“…Previous studies have shown that REO exerted antiproliferative effects against various cancer cells via inhibition of the signaling pathways for survival and proliferation (Wang et al 2012;Valdes et al 2013;Melusova et al 2014;Valdes et al 2016;Sujatha and Sirisha 2019). A recent study demonstrated high toxicity of liposomal carriers for REO against MCF7 cells due to the enhancement of REO delivery to the target cells (Salari and Salari 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The bioactive components of REO stimulate pathways responsible for apoptotic cell death in HepG2 cells (Melusova et al 2014). Therefore, the increased apoptosis in cells treated with the combined formulation indicates that REO/NE would be an efficient carrier of MC since it enhanced MC delivery and its effect on the target cells through the induction of nuclear apoptosis (Salari and Salari 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Gezici et al (2017) reported that REO produced strong inhibitory effect on the proliferation of different cancer cell lines: human lung adenocarcinoma (A549), human non-small lung cancer (H1299), and human breast adenocarcinoma (MCF-7), with IC 50 values ranging from 3.06 to 7.38 µg/ml. The anticancer effect of REO on MCF-7 cells was improved when administered in form of a liposomal system, relative to free REO (Salari and Salari 2019). In another study, it was reported that at high concentrations, REO induced apoptosis signaling pathways, DNA fragmentation and arrest of hepatoma (HepG2) cells in the G1 phase of the cell cycle (Melušová et al 2014).…”

Section: Introductionmentioning

confidence: 98%

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Rosemary oil nano-emulsion potentiates the apoptotic effect of mitomycin C on cancer cells in vitro

Al-Otaibi¹

2021

PHAR

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Purpose: To formulate nano-emulsified rosemary oil (REO/NE) and determine its effect on the anticancer agent, mitomycin C (MC) when used as a carrier for the drug. Methods: The droplet size of REO/NE was markedly enlarged when mixed with MC. The cytotoxicity of the formulations on HeLa and MCF-7 cells was determined using MTT assay. The combination index (CI) values were estimated with CompuSyn software, while apoptosis was determined using DAPI fluorescent dye. Results: Treatment of MCF-7 cells and HeLa cells with REO/NE (1% v:v and 1.33% v:v, respectively) reduced the IC50 of MC 33 and 15 folds, respectively. Under fluorescent microscopy, cells treated with REO/NE+MC had more marked reduction of the nuclear area than MC-treated cells. Conclusion: These results indicate that REO/NE is an efficient carrier for MC since it enhanced MC delivery and increased its effect on the cells through the induction of apoptosis at low concentrations of MC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Rosemary oil nano-emulsion potentiates the apoptotic effect of mitomycin C on cancer cells in vitro

Al-Otaibi¹

2021

PHAR

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“…To improve both the stability and delivery of rosemary EO exhibiting useful antioxidant and antimicrobial effects, encapsulating nanoliposomes were developed. The results showed that the liposomal EO had higher toxic effects on MCF7 cells due to enhanced drug delivery [ 119 ].…”

Section: Nanoformulations Involving Vegetable Oil-based Nutraceutimentioning

confidence: 99%

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

Vergallo

2020

Nanomaterials

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The scientific community is becoming increasingly interested in identifying, characterizing, and delivering nutraceuticals, which constitutes a multi-billion-dollar business. These bioactive agents are claimed to exhibit several health benefits, including the prevention and treatment of diseases such as arthritis, cancer, osteoporosis, cataracts, Alzheimer’s, and Huntington’s diseases, heart, brain and metabolic disorders, etc. Nutraceuticals are typically consumed as part of a regular human diet and are usually present within foods, comprising vegetable oil, although at low levels and variable composition. Thus, it is difficult to control the type, amount and frequency of their ingestion by individuals. Nanoformulations about vegetable oil-based bioactive compounds with nutraceutical properties are useful for overcoming these issues, while improving the uptake, absorption, and bioavailability in the body. The purpose of this current study is to review papers on such nanoformulations, particularly those relevant for health benefits and the prevention and management of diseases, as well as bioactives extracted from vegetable oils enhancing the drug effectiveness, retrieved through bibliographic databases by setting a timespan from January 2000 to April 2020 (about 1758 records).

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“…High power ultrasounds can break-down chemical bonds depolymerizing macromolecules, downsizing particles to nanoscale, making nanoemulsions, extracting bioactive substances from different matrices and so on, in research laboratories, in pharmaceutical and agrifood industries [40][41][42][43]. Sonochemistry was recently investigated for synthesis of bioactive nanostructures [44], different nanocarriers such as niosomes [45], liposomes [46], nanoemulsions [47], solid lipid nanoparticles [48], metal based systems [49], polymeric particles [50], nanoclusters [51] and nanocomposites [43]. Sonication processes were mainly performed to extract or degrade pesticides in order to support analysis and decontamination activities [52,53].…”

Section: Nanopesticides and Sonication Technologymentioning

confidence: 99%

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Baldassarre

Tatulli²,

Vergaro

et al. 2020

Nanomaterials

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Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. This work proposed a nanotechnological approach to obtain a new formulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigation was carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on two Xylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa.

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Nanoliposomal system of rosemary essential oil made by specific human cell phospholipids and evaluation of its anti-cancer properties

Cited by 16 publications

References 16 publications

Rosemary oil nano-emulsion potentiates the apoptotic effect of mitomycin C on cancer cells in vitro

Rosemary oil nano-emulsion potentiates the apoptotic effect of mitomycin C on cancer cells in vitro

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

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