Characterization of nebulized buparvaquone nanosuspensions—effect of nebulization technology

Hernández-Trejo, Norma; Kayser, Oliver; Steckel, Hartwig; Müller, Rainer H.

doi:10.1080/10611860500353245

Cited by 41 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Basically, such nanomedicines consist of DNCs dispersed in liquid medium, and are stabilized by surface-active agents, such as the poloxamer family, [169][170][171][172][173] Tween, [174][175][176] and polymers. [177][178][179][180] For oral administration, the high surface:volume ratios of DNCs significantly increase dissolution velocity, thereby leading to an improvement in the gastrointestinal tract absorption based on the Noyes-Whitney equation.…”

Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

View full text Add to dashboard Cite

Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

show abstract

Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

View full text Add to dashboard Cite

show abstract

“…All the aerosol droplets contain drug nanoparticles due to the presence of small particles. There are various drugs which are successfully tried with pulmonary route such as budesonide, p53 gene, ibuprofen, nifesipine, and ketotifen etc 58 .Coenzyme Q10 is an antioxidant substance which is indicated as a dietary supplement and proposed as adjuvant in the management of cardiovascular disorders and tumor for its protective and immunostimulating activities. CoQ10 nanosuspension designed and administreted to the lungs by nebulization.…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

Azimullah¹,

Sudhakar²,

Kumar³

et al. 2019

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Techniques like high-pressure homogenization, wet milling, emulsification, solvent evaporation, bottom up technology and top down technology have been applicable in the fabrication of nanosuspensions. Nanosuspension delivery is possible by several routes, such as oral, pulmonary, parenteral and ocular routes. Nanosuspension not only solves solubility and bioavailability issue, but improve drug safety and efficacy. In this context, we reviewed the current techniques used to develop nanosuspensions and their recents studies application in drug delivery system. Keywords : Solubility, fabrication, Characterization, Applications, Nanosuspension.

show abstract

“…For pulmonary delivery, aerosolization of nanosuspensions is possible. 117 An overview of current market products based on nanosuspensions technologies has been reviewed by Shegokar and Müller 118 and presented in Table 2. In this article, mainly the transformation of liquid nanosuspensions into solid dosage forms will be discussed.…”

Section: Downstream-drug Product Processingmentioning

confidence: 99%