Characterization of rotavirus possessing a DS-1-like VP3 gene from pigs in Brazil: Evidence for zooanthroponotic transmission

Neves, Mayara Annanda Oliveira; Júnior, Alcinês da Silva Sousa; Camargo, Daniel Stangarlin de; Lobo, Patrícia dos Santos; Bandeira, Renato Silva; Soares, Luana da Silva; Mascarenhas, Joana D’Arc Pereira

doi:10.1016/j.meegid.2019.104151

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Strains of the influenza virus are often transmitted from humans to swine (Nelson and Vincent, 2015). Also, a probable human-to-porcine transmission of rotavirus strains was recently reported in Brazil (Neves et al, 2020), and there is evidence of the transmission of SARS-CoV-2 from humans to dogs (Sit et al, 2020). Reverse zoonosis is a concern in terms of both public health and wildlife conservation (Olival et al, 2020).…”

Section: Human Host-associated Factorsmentioning

confidence: 99%

Zoonotic spillover: Understanding basic aspects for better prevention

2021

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The transmission of pathogens from wild animals to humans is called "zoonotic spillover" . Most human infectious diseases (60-75%) are derived from pathogens that originally circulated in non-human animal species. This demonstrates that spillover has a fundamental role in the emergence of new human infectious diseases. Understanding the factors that facilitate the transmission of pathogens from wild animals to humans is essential to establish strategies focused on the reduction of the frequency of spillover events. In this context, this article describes the basic aspects of zoonotic spillover and the main factors involved in spillover events, considering the role of the inter-species interactions, phylogenetic distance between host species, environmental drivers, and specific characteristics of the pathogens, animals, and humans. As an example, the factors involved in the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic are discussed, indicating what can be learned from this public health emergency, and what can be applied to the Brazilian scenario. Finally, this article discusses actions to prevent or reduce the frequency of zoonotic spillover events.

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Section: Human Host-associated Factorsmentioning

confidence: 99%

Zoonotic spillover: Understanding basic aspects for better prevention

2021

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“…There have been detection of around 10% infections in pigs caused by group A RVs in the Metropolitan Region of Belém, with the predominance of G3 and G5 genotypes, also bearing P genotypes P[13]/ [22] and P [23] 57 . Two of these RVA strains were characterized to have VP3 genes of human origin possessing DS-1-like backbone, suggesting to have evidence for human-to-porcine zooanthroponotic transmission 58 . In contrast, in developing countries, including Asian and sub-Saharan African countries, RV strains of human origin displaying unusual G and P combinations have been seen frequently, including reassortment events involving RVs strains of animal origin 38,59 .…”

Section: Discussionmentioning

confidence: 99%

Group A rotavirus gastroenteritis in orphaned Leopardus tigrinus and Leopardus pardalis (Carnivora: Felidae) in the Eastern Amazon

Gabriel¹,

Pereira²,

Silva³

et al. 2023

Revista Pan-Amazônica de Saúde

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Rotaviruses are highly infectious and transmitted by the fecal-oral route, representing a leading cause of diarrheal deaths in children in developing countries. Additionally, it causes significant economic impacts as an enteropathogen among domestic animals. This report presents clinical and diagnostic findings in two cases of rotavirus (RV) infection involving orphaned Leopardus tigrinus (Schreber, 1775) and Leopardus pardalis (Linnaeus, 1758), representing the first registered group A RV (RVA) infection in these species. Both felids were rescued in Pará State, Amazon Region, by the Brazilian Institute of Environment and Renewable Natural Resources and treated in an intensive care ward in a public Environmental Park of Belém City. After adaptation up to the 40th day of the quarantine period, these animals had no typical symptoms of acute, fulminant gastroenteritis. The collected samples were examined at the Virology Laboratory of Instituto Evandro Chagas. RVA antigen was detected in the blood and fecal samples of L. tigrinus by enzyme-linked immunosorbent assay and immunochromatography. RVA-positive samples were subjected to polyacrylamide gel electrophoresis and reverse transcriptase polymerase chain reaction for VP4 and VP7 genes using conventional set primers but with negative results. Stools were examined for ova and parasites yielding negative results and for intestinal endoparasites, yielding negative results. The animals died within a few days following a clinical exacerbation, therefore unresponsive to treatment. Necropsies and histopathological analysis were performed at the Laboratory of Veterinary Pathology of Universidade Federal Rural da Amazônia. Despite the pathologic findings typical of RV infection hemorrhagic enteritis was unusual if presumed etiology is considered.

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Characterization of rotavirus possessing a DS-1-like VP3 gene from pigs in Brazil: Evidence for zooanthroponotic transmission

Cited by 2 publications

References 23 publications

Zoonotic spillover: Understanding basic aspects for better prevention

Zoonotic spillover: Understanding basic aspects for better prevention

Group A rotavirus gastroenteritis in orphaned Leopardus tigrinus and Leopardus pardalis (Carnivora: Felidae) in the Eastern Amazon

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