Characterization of silver nanoparticles synthesized using Urtica dioica Linn. leaves and their synergistic effects with antibiotics

Kumari, Jyoti; Baunthiyal, Mamta; Singh, Ajeet

doi:10.1016/j.jrras.2015.10.002

Cited by 722 publications

(480 citation statements)

References 36 publications

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“…Apart from these, cellular porous permeability was found indirectly proportional to volume of experimental colloid and time of exposure [7]. Thorny tiny silver nano particle with breadth and diameter below 1.55 to 19.57 nm range after specific experimental application found to be initiative of certain chronic kidney inflammatory diseases, [8] nano metal of this category also become barrier in proper development of viruses, fungus and certain dangerous parasites. Small size nano particles tremendously heals damaged tissue after hurts from fire injury, traumatic injury and certain diabetic and diseased wound but the negative feedback is after smooth absorption from skin it causes indirect damage to internal organs like liver and kidney followed by chronic deposition [9].…”

Section: Size Dependant Nephrotoxicity Focus In Indirect Responsementioning

confidence: 98%

“…The objective of this assessment is the highlights, limitations, current and future challenges for small size silvernano nephrotoxicity focus [17,18]. Jyoti et al and other scientist quoted that herbal synthesis and characterization of nano silver has ameliorative effect along with nephrotoxic effects [19]. Also some of the recent researches from relevant eminent scientists declares, EPA takes action to protect public from an illegal nano silver pesticide in food containers cites NJ company for selling food containers with an unregistered pesticide warns large retailers not to sell these products.…”

Section: Nephrotoxicity From Histological Point Of Viewmentioning

confidence: 99%

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Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

Prakash¹,

Singh²,

Pani³

2017

J Cytol Histol

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The most important and worldwide utilized nanomaterial is silver metal nanoparticle which after synthesis changed to colloidal or powdered form. After successful characterization different sizes of these particles measured if intermixed and confirmed to different size ranges. Different sizes segregates into various size groups. Specific small or large size silver in powder form also readily available in market for various applications and experiments after biological or herbal synthesis and characterization. 1 to 20 nm size ranges are grouped under inconsiderable or smaller size range whereas 20 to 100 nm size ranges or above sizes are grouped under considerable or bigger size range. Following serial oral ingestion for experiment, aqueous and magnetic stirred synthesized AgNps of less than 20 nm of null account size accumulate in mature and developing kidneys of pregnant Swiss Albino mice and their freshly born fetuses after passing through blood vessels of pregnant mice and after absorption from gastro intestinal tract and accumulate in mature kidney due to trap inside. These particles also crosses blood placental barrier reaches fetus body in womb and accumulate in developing kidney due to same mechanism. These particles also surprisingly execute sex specific corrosive manifestation. We have examined the corrosive and hazardous effect of 10 gestational days (5 to 15 gestational days) serial oral bolus ingestion of 2.75 to 18.5 nm size range AgNps colloidal solution in a lower dose of 0.35 (1), 0.55 (2) mg/kg. b.w, in an in between dose of 4 (3), 8 (4) mg/ kg. b.w. and in a higher dose of 12 (5) and 16 (6) mg/kg. b.w. treatment on mature and developing right and left kidneys of pregnant mice and fetuses. Groups were designated as 1(Control); 2, 3, 4, 5 and 6 (Treated). At lower dose we report negligible histological findings and at higher bolus dose we report marked histological findings. This particular size range group silver nano particles (AgNps) treatment turns into insignificant reduction in kidney weight and height at higher dose, with some hemorrhagic focuses along with histological alterations. Predominantly agenesis and severe atrophy of renal corpuscles, increase of urinary space, generalized anasarca of podocytes, degeneration and dysmorphology with congestion of proximal convoluted tubules and distal convoluted tubules, loss of brush border membranes and damage of squamous epithelium of loop of Henley with severe congestion in medullary rays and collecting ducts are observed in routine histology. The in between dose demonstrated in between results. These manifestations are found quite same to chronic and acute renal failure with hematuria. All these alterations, in prolong sustain, could land up to beginning of apoptosis and progress of cell necrosis in these vital organs.

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Section: Size Dependant Nephrotoxicity Focus In Indirect Responsementioning

confidence: 98%

Section: Nephrotoxicity From Histological Point Of Viewmentioning

confidence: 99%

Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

Prakash¹,

Singh²,

Pani³

2017

J Cytol Histol

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“…The drugs derived from herbs may have the possibility of their use in medicine because of their good antibacterial activity. Thus, the AgNPs have the maximum zone of inhibition in the process [33][34][35][36]. The bacterial pathogen R. rhodochrous showed the maximum zone of inhibition (11.8±0.447).…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Biogenic silver nanoparticles mediated by Broussonetia papyrifera: anticancer and antimicrobial activity against pathogenic organisms

Vasanth¹,

Melchias

Kumaravel³

2017

Asian J Pharm Clin Res

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Objective: To evaluate the potential aspects of biologically synthesized silver nanoparticles (AgNPs) mediated by Broussonetia papyrifera against the human pathogens. The same is acknowledged to have high efficiency in the field of Pharmaceutical industry. Methods:The 1 mM of AgNO 3 is prepared and mixed with an appropriate volume of plant extract and reaction volume was made up to 100 ml. The physical characterization of AgNPs was done. The antimicrobial activity was done against dread pathogens. Cytotoxic activity of the AgNPs was investigated against breast and lung cancer cell lines. Results:The field emission scanning electron microscopy and energy dispersive X-ray spectroscopy of the microscopic level showed the particle surface measurements around 44-50 nm. The X-ray powder diffraction investigations are being an evidence for the crystalline structure of the AgNPs with 30 nm. The bacterial pathogen Rhodococcus rhodochrous showed the maximum zone of inhibition (11.8±0.447). The A549 human lung cancer cell line and MCF-7 human breast cancer cell line were tested against the toxicity of AgNPs. The toxicity of AgNPs was valued and corresponding inhibitory concentration for lung cancer (A549) is 12.95±0.05 µg/mL and breast cancer (MCF-7) is 10.75±0.05 µg/mL, respectively. Conclusion:This research denotes that biomolecules derived AgNPs have a larger impact as antimicrobials in the biomedical field. Since the aggressive chemicals are not involved AgNPs production, these bio-substances can of alternative medicine to resistant once. The in-vitro experiments exhibit the therapeutic effect of this AgNPs based on the ambient concentration on the process.

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“…Indeed, silver has highly specific surface area for its maximum contact with environment and has strong antimicrobial property. [5] When comparing the noble metals, silver is also the widely used metal due to its unique properties as wound healer agent its use in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of Mangifera indica silver nanoparticles and its analysis using Fourier transform infrared and scanning electron microscopy

Bharathi¹,

Firdous²,

Muhamad³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Cost effective and environmentally favorable green synthesis of metallic nanoparticles is a fast growing research in nanotechnology. Aims and Objectives: The present study reports the synthesis of silver nanoparticle (AgNP) using Mangifera indica leaves extract, and its constituents and particle size was analyzed by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). Materials and Methods: Preliminary phytochemical analysis of M. indica leaves extract was performed, and AgNPs were prepared by M. indica leaves extract when treated with silver nitrate. Finally, various functional groups in the plant extracts and size of the AgNPs were identified by FTIR and SEM analysis. Results: Qualitative phytochemical analysis revealed the presence of alkaloids, tannins, flavonoid, quinines, steroids, coumarins, and phenolic compounds in M. indica leaves extract. Presence of AgNPs in the green extract was confirmed by color changes from pale yellow to dark brown color and by an intense peak in the ultravioletspectrophotometer at 420 nm. FTIR analysis showed the presence of various functional groups between the frequency range of 400 and 4000/cm and SEM analysis showed the nanometer size of silver particles that formed. Conclusion: This novel green approach may be used for large scale production of metallic nanoparticle and can be used in pharmacological aspects based on the medicinal uses of M. indica.

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Characterization of silver nanoparticles synthesized using Urtica dioica Linn. leaves and their synergistic effects with antibiotics

Cited by 722 publications

References 36 publications

Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

Biogenic silver nanoparticles mediated by Broussonetia papyrifera: anticancer and antimicrobial activity against pathogenic organisms

Green synthesis of Mangifera indica silver nanoparticles and its analysis using Fourier transform infrared and scanning electron microscopy

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