Characterization of Staphylococcus aureus mutants expressing reduced susceptibility to common house-cleaners

Davis, A.O.; O'Leary, Jessica O.; Muthaiyan, Arunachalam; Langevin, Mark J.; Delgado, A.; Ábalos, A.; Fajardo, Alicia; Marek, Jan; Wilkinson, Brian J.; Gustafson, John E.

doi:10.1111/j.1365-2672.2004.02460.x

Cited by 33 publications

(37 citation statements)

References 29 publications

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“…There has also been one report suggesting that E. coli strains harboring mutations in the multiple antibiotic resistance (mar) operon, so-called Mar mutants, may exhibit decreased susceptibility to TTO (66). Minor changes in TTO and ␣-terpineol susceptibilities have also been seen in S. aureus isolates with reduced susceptibility to household cleaners (53). However, in these last two studies the changes in susceptibility were marginal and do not represent strong evidence of resistance (53,66).…”

Section: Resistance To Ttomentioning

confidence: 95%

“…Minor changes in TTO and ␣-terpineol susceptibilities have also been seen in S. aureus isolates with reduced susceptibility to household cleaners (53). However, in these last two studies the changes in susceptibility were marginal and do not represent strong evidence of resistance (53,66). With regard to fungi, an attempt to induce resistance to TTO in two clinical isolates of Candida albicans was largely unsuccessful, with isolates failing to grow in 2% (vol/vol) TTO after serial passage in increasing concentrations of TTO (111).…”

Section: Resistance To Ttomentioning

confidence: 99%

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Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

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Section: Resistance To Ttomentioning

confidence: 95%

Section: Resistance To Ttomentioning

confidence: 99%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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“…Mutants of S. aureus expressing reduced susceptibility to common house cleaners demonstrate increased resistance to multiple antimicrobials [9,30], and growth of S. aureus in the presence of the non-steroidal anti-inflammatory salicylate also elicits a multiple antimicrobial resistance mechanism [4][5][6]8,10,15]. The salicylate-inducible mechanism in S. aureus is in part mediated by a reduction in the accumulation of antimicrobials [10].…”

Section: Introductionmentioning

confidence: 99%

Contributions of sigB and sarA to distinct multiple antimicrobial resistance mechanisms of Staphylococcus aureus

Riordan

O'Leary

Gustafson

2006

International Journal of Antimicrobial Agents

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Multiple antimicrobial resistance in Staphylococcus aureus can result from mutations leading to reduced susceptibility to Pine oil-based cleaners (PS(RS)) as well as following growth with the non-steroidal anti-inflammatory salicylate. We now define the contributions of the alternative sigma factor (sigB) and staphylococcal accessory regulator (sarA) to these mechanisms. We conclude that sarA plays a more prominent role than sigB in overall intrinsic multiple antimicrobial resistance. Both genes have similar effects on intrinsic vancomycin resistance, and the salicylate-inducible mechanism is not sigB- or sarA-dependent. Furthermore, analyses determined that altered expression of sigB and sarA is not responsible for the salicylate-inducible mechanism, and sarA upregulation is associated with the PS(RS) phenotype.

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“…As we have seen in this review, carotenoids have been in some cases associated with antibiotics resistance in bacteria (36,37,69). However, mycobacterial pigments, even though they have been clearly associated with cellular photoprotection and survival still have to be related to drugs resistance.…”

Section: The Future Of Mycobacterial Pigmentsmentioning

confidence: 98%

“…Conversely, heterologous expression of the Staphylococcus aureus carotenoid in the nonpigmented Streptococcus pyogenes confers enhanced oxidant and neutrophil resistance and increased animal virulence. Also, acquisition of Staphylococcus aureus resistance to vancomycin has been related to a yellow carotenoid pigment formation, and blocking the bacterium carotenogenesis has been shown to decrease its whole-blood survival (37).…”

Section: Carotenoids and Bacterial Pathogenesismentioning

confidence: 99%

Physiological role and potential clinical interest of mycobacterial pigments

2011

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The production of pigments by bacterial colonies has sparked interest among bacteriologists since the 19th century, whether for taxonomy or, in the case of carotenoids for their association with antibiotics resistance. Mycobacteria have gained a very special place in the bacterial world due to their clinical importance. Alone, Mycobacterium tuberculosis is responsible for about two million deaths annually worldwide making tuberculosis one of the most influential diseases in the history of mankind. Almost half of the Nontuberculous Mycobacteria species identified are associated with opportunistic infections in animals and humans. Mycobacterial pigmentary characteristics started to be documented about 80 years ago; but to date, their main use has been only for limited taxonomic and identification purposes. While mycobacterial pigments, especially carotenoids have been clearly associated with cellular photoprotection and survival, the regulation of their production and their physiological role have been largely unstudied. Recent advances in deciphering mycobacterial genomes and characterization of carotenoid synthesis genes, combined with an urgent need for innovative approaches to understand Mycobacterium tuberculosis pathogenic properties open new avenues for exciting research opportunities that might lead to new therapeutic strategies against a devastating secular disease. © 2011 IUBMB IUBMB Life, 63(2): 71–78, 2011

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Characterization of Staphylococcus aureus mutants expressing reduced susceptibility to common house-cleaners

Abstract: Aims: To characterize mutants of Staphylococcus aureus expressing reduced susceptibility to house cleaners (HC), assess the impact of the alternative sigma factor SigB on HC susceptibility, and determine the MIC of clinical methicillin-resistant S. aureus (MRSA) to a HC.

Cited by 33 publications

References 29 publications

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Contributions of sigB and sarA to distinct multiple antimicrobial resistance mechanisms of Staphylococcus aureus

Physiological role and potential clinical interest of mycobacterial pigments

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