Characterization of strains of Neisseria meningitidis causing meningococcal meningitis in Mozambique, 2014: Implications for vaccination against meningococcal meningitis

Munguambe, Alcides Moniz; Almeida, Andréa Sobral de; Nhantumbo, Aquino Albino; Comé, Charlotte Elizabeth; Zimba, Tomás F.; Langa, José Paulo; Filippis, Ivano de; Gudo, Eduardo Samo

doi:10.1371/journal.pone.0197390

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…The nurse should educate the parents on ensuring that the children are vaccinated against neisseria meningitides. All contacts should be educated about the signs and symptoms of the infection and when to return to the emergency room (Munguambe, 2018) The nurse should be explained the procedure and its risks to the patient and informed consent obtained if relevant in the practice setting. The description should include how the procedure will be performed, why it is being performed, what complications may occur, and how these can be treated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Teaching Program Regarding Care for Acute Meningitis on Nurses Performance at Emergency Unit

Mohammed¹,

Mohammed

Ahmed

2019

Assiut Scientific Nursing Journal

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Background: Meningitis is defining the patients as having inflammation of the meninges with a continuous fever. The triage nurse must be fully aware of the signs and symptoms of the disease and refer the patient immediately to the emergency room physician. The aim of this study was carried out to evaluate the effect of teaching program about nursing care of acute meningitis on nurse's performance at emergency units. Subjects and method, A quasiexperimental research design was used to conduct this study at the emergency unit at assiut university hospital Sample All available of nurses (30 nurses). Results: The results of the study present that the effectiveness of teaching program regarding nurses knowledge toward acute meningitis is a positive in post-test of teaching program.(knowledge at pre program is15.5%.However, knowledge at post program become 48.5%. Practice at pre program is8.6%.However, Practice at post program become 23.7%). Conclusion: The majority of nurses had satisfactory knowledge and skills toward acute meningitis after applying of teaching program more than before implementation of program with statistical significant differences between pre-post teaching program. Recommendation: The study recommended that the latest guidelines of acute meningitis should be available in written format in critical and emergency units.

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Section: Introductionmentioning

confidence: 99%

Effect of Teaching Program Regarding Care for Acute Meningitis on Nurses Performance at Emergency Unit

Mohammed¹,

Mohammed

Ahmed

2019

Assiut Scientific Nursing Journal

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“…Furthermore, the results found that age of patient had significant prognostic effect and relation to complications of meningitis with p-value less than 0,05 in both of 2015 and 2016 as its illustrated in the figure (2). Seasonally, figure (3) Moreover, we found that males were highly affected by meningitis over all seasons of 2015 except the summer (figure 4), also, high meningitis infects patient aged between (20-44 years old) during all seasons of the same year except winter (figure 5). However, these seasonal interactions of meningitis infection with age and sex are non-significant statistically during the year 2015.…”

Section: Resultsmentioning

confidence: 67%

“…The phenotypic classification of meningococci, based on structural differences in capsular polysaccharide, lipooligosaccharide (LOS) and outer membrane proteins, is now complemented by genome sequence typing (ST). Meningococcal meningitis is often serious and potentially fatal and death occurs on average in 10% of untreated patients (3). According to the World Health Organization (WHO), an estimated 500,000 cases and 50,000 deaths are attributed to N. meningitidis each year worldwide.…”

Section: Introductionmentioning

confidence: 99%

Identification, Epidemiology, and Seasonal Variation of Neisseria meningitides in Al-Nasiriya city. South of Iraq.

Neamah¹,

Abdullah²

2020

Preprint

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In order to investigate the incidence of Neisseria meningitides meningitis in AL Nasiriya city, and to evaluate the effects of sociodemographic factors on infection, the current study involved (219) patients suffering from meningitis who attended in AL-Hussein Teaching Hospital in for two consecutive years (beginning of 2015 to the end of 2016). CSF samples are collected from the study population by the technician then transported immediately to the laboratory for the detection of the bacterial pathogens. The results showed that there are 57 (26.02%) patients infected with Neisseria meningitides. Of them 29 (50.87%) cases occurred during 2015 and (28) cases (49.13%) occurred during 2016. Our results also found that Neisseria meningitides meningitis infection was significantly higher in men than in females (P-value =0.046), and in patients from the age group (44-66 years old). Seasonal variation was also seen in the occurrence of meningococcal meningitis infections during the study period. The present study concluded that meningococcal meningitis infections were influenced by sociodemographic factors, the infections appear to be dominant in the long warm seasons of Iraqi weather.

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“…Biobanking is becoming increasingly recognised and utilised in Africa in a variety of fields including stroke [7], oncology [8], infectious disease [9] and pregnancy. This summary represents a practical account of the necessary stages required in setting up a large multi-country biorepository and database in low income settings.…”

Section: Discussionmentioning

confidence: 99%

PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa

Craik

Russell²,

Tribe

et al. 2020

Reprod Health

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Background and objective: PRECISE is a population-based, prospective pregnancy cohort study designed for deep phenotyping of pregnancies in women with placenta-related disorders, and in healthy controls. The PRECISE Network is recruiting~10,000 pregnant women in three countries (The Gambia, Kenya, and Mozambique) representing sub-Saharan Africa. The principal aim is to improve our understanding of pre-eclampsia, fetal growth restriction and stillbirth. This involves the creation of a highly curated biorepository for state of the art discovery science and a rich database of antenatal variables and maternal and neonatal outcomes. Our overarching aim is to provide large sample numbers with adequate power to address key scientific questions. Here we describe our experience of establishing a biorepository in the PRECISE Network and review the issues and challenges surrounding setup , management and scientific use. Methods: The feasibility of collecting and processing each sample type was assessed in each setting and plans made for establishing the necessary infrastructure. Quality control (QC) protocols were established to ensure that biological samples are 'fit-for-purpose'. The management structures required for standardised sample collection and processing were developed. This included the need for transport of samples between participating countries and to external academic/commercial institutions. Results: Numerous practical challenges were encountered in setting up the infrastructure including facilities, staffing, training, cultural barriers, procurement, shipping and sample storage. Whilst delaying the project, these were overcome by establishing good communication with the sites, training workshops and constant engagement with the necessary commercial suppliers. A Project Executive Committee and Biology Working Group together defined the biospecimens required to answer the research questions paying particular attention to harmonisation of protocols with other cohorts so as to enable cross-biorepository collaboration. Governance structures implemented include a Data and Sample Committee to ensure biospecimens and data will be used according to consent, and prioritisation by scientific excellence. A coordinated sample and data transfer agreement will prevent delay in sample sharing.

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Characterization of strains of Neisseria meningitidis causing meningococcal meningitis in Mozambique, 2014: Implications for vaccination against meningococcal meningitis

Cited by 15 publications

References 31 publications

Effect of Teaching Program Regarding Care for Acute Meningitis on Nurses Performance at Emergency Unit

Effect of Teaching Program Regarding Care for Acute Meningitis on Nurses Performance at Emergency Unit

Identification, Epidemiology, and Seasonal Variation of Neisseria meningitides in Al-Nasiriya city. South of Iraq.

PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa

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