Characterization of the Chicken Apolipoprotein A-I Gene 5′-Flanking Region

Bhattacharyya, Nisan; Chattapadhyay, Ranjan; Oddoux, Carole; Banerjee, Dev

doi:10.1089/dna.1993.12.597

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…Moreover, we show the presence of both an activating (DR l) and modulating (DR2) sequence in the same response element as an interesting feature of the transcriptional regulation of the HD gene. This phenomena is also observed in the regulation of the hApoAI gene [16] and the mCRBPI1 gene [12]. Recent findings show that COUP-TF is able to bind to the 2 first motifs of this response element [9].…”

Section: Discussionmentioning

confidence: 81%

The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs

Bardot¹,

Clémencet²,

Passilly³

et al. 1995

FEBS Letters

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Key words: Peroxisome proliferator-activated receptor; Peroxisome proliferator response element; 9-cis Retinoic acid receptor alpha; Rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase; Transcriptional activation sists of direct repeats of the sequence TGACCT, the consensus binding sequence for several members of the nuclear steroid hormone receptor superfamily [7]. PPAR binds to these PPREs through heterodimerization with the 9-cis retinoic acid receptor RXR~ [4,8]. Transcriptional activation is regulated by diverse auxiliary transcription factors that can act as activators or repressors. For instance, the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) can bind to the HD-PPRE and antagonizes peroxisome proliferators activation [9]. In fact, different studies on hormone response elements have shown that many known and unknown factors are able to bind promiscuous sequences [10][11][12]. Here we show that the PPAR-RXR heterodimer activates transcription via the DR1 part of the HD-PPRE and that other transcription factors modulate the level of induction via the most 5"-receptor motif in DR2.

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Section: Discussionmentioning

confidence: 81%

The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs

Bardot¹,

Clémencet²,

Passilly³

et al. 1995

FEBS Letters

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“…ApoAI is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. It is a major protein component of plasma high-density lipoprotein in all species, and plays an important role in cholesterol homeostasis (Bhattacharyya et al, 1993). In our previous study (Wang et al, 2006), ApoAI were found to be DE in adipose tissue between broilers and layers.…”

Section: Discussionmentioning

confidence: 91%

Microarray analysis of genes differentially expressed in the liver of lean and fat chickens

Wang

Zhang

et al. 2010

Animal

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Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver at developmental stages of chicken (1 week, 4 weeks and 7 weeks of age) were investigated and differentially expressed genes between lean and fat chicken lines divergently selected for abdominal fat content for eight generations were screened. Our data indicated that 4 weeks of age was a very important stage on chicken liver lipogenesis compared to 1 week and 7 weeks of age, and the glycometabolism in chicken liver could be related to lipid metabolism and the difference of glycometabolism could be another potential reason for the fat and lean phenotype occurrence besides the difference of lipogenesis in chicken liver. Our result have established groundwork for further study of the basic genetic control of chicken obesity and will benefit chicken research communities as well as researches that use chicken as a model organism for developmental biology and human therapeutics.

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“…Apolipoprotein A-I is a lipid-binding protein that participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux CHICKEN ADIPOSE TISSUE DIFFERENTIAL PROTEOMICS from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (Mukhamedova et al, 2008). It is a major component of high-density lipoprotein and plays an important role in cholesterol dynamic balance (Bhattacharyya et al, 1993). Genetic deficiency in APOA-I is associated with excessive intracellular cholesterol accumulation in humans and poultry (Breslow, 1989;Kiss et al, 2001;Wang et al, 2006a).…”

Section: Proteomic Analysis Of Adipose Tissue Between Fat and Lean Brmentioning

confidence: 99%

Identification of differentially expressed proteins in adipose tissue of divergently selected broilers

Wang

et al. 2009

Poultry Science

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Reducing fat has been a major goal for the broiler industry. To gain insight into the molecular mechanisms underlying the regulation of fat deposition in chickens, a 2-dimensional electrophoresis-based proteomic approach was used to analyze the differentially expressed proteins in abdominal adipose tissues of Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF). A total of 20 differentially expressed protein spots were found in abdominal adipose tissue between fat and lean broilers at 7 wk of age. Among them, 12 protein spots were upregulated and 8 protein spots were downregulated in fat birds compared with those in lean birds. These 20 protein spots were then identified by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry and matched to 15 proteins by searching against the NCBInr and SWISS-PROT databases, including adipocyte fatty acid-binding protein, apolipoprotein A-I, long-chain acyl-coenzyme A dehydrogenase, heat shock protein beta 1, glutathione S-transferase theta 1, glutathione S-transferase class alpha, guanine nucleotide-binding protein beta polypeptide 1, syntaxin 2, vimentin, cofilin 2, otokeratin, telomerase catalytic subunit, and 3 hypothetical proteins. These proteins are mainly related to lipid metabolism, chaperone, redox, signal transduction, transport, and cytoskeleton. The results, from the point of view of protein expression, establish the groundwork for further studies of the basic genetic control of growth and development of broiler adipose tissue.

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Characterization of the Chicken Apolipoprotein A-I Gene 5′-Flanking Region

Cited by 9 publications

References 35 publications

The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs

The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs

Microarray analysis of genes differentially expressed in the liver of lean and fat chickens

Identification of differentially expressed proteins in adipose tissue of divergently selected broilers

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