Characterization of the Developmental Stages

The clinical history and autopsy findings of a 22-week fetus with intestinal ganglioneuroblastoma, cardiac anomalies, omphalocele, and ileal atresia are presented. Ganglioneuroblastoma was confined to the large intestine and was not suspected prenatally despite ultrasonographic examination. Although enteric ganglia share neural crest lineage with other sites of congenital neuroblastoma, this is the first report of a primary intestinal ganglioneuroblastoma in a fetus or child. Various hypotheses are discussed to explain the coexistence of cardiac malformation and congenital neuroblastoma in this fetus and other cases in the literature. It is hypothesized that other malformations evident in this fetus were caused by the tumor, possibly as teratogenic effects of neuroblastoma-derived catecholamines during embryogenesis.

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Characterization of the Developmental Stages

Cited by 2 publications

References 22 publications

Chorionic Villus Sampling and Materno-Fetal Transfusions: An Immunological Pathogenesis of Vascular Disruptive Syndromes?

Chorionic Villus Sampling and Materno-Fetal Transfusions: An Immunological Pathogenesis of Vascular Disruptive Syndromes?

Intestinal Ganglioneuroblastoma in a 22-Week Fetus

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