Characterization of the LOAEL-to-NOAEL Uncertainty Factor for Mild Adverse Effects from Acute Inhalation Exposures

Alexeeff, George V.; Broadwin, Rachel; Liaw, Jane; Dawson, Stanley V.

doi:10.1006/rtph.2002.1562

Cited by 57 publications

(42 citation statements)

References 15 publications

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“…viridiflorum water extract was toxic (LD 50 1000 mg/ kg body weight); however, no mortality or signs of toxicity were observed for the rest of the water extracts after oral administration of a single dose at any dose level up to the highest dose tested (5000 mg/kg) which was the no-observed-adverse-effect level (NOAEL) (Alexeeff et al, 2002).…”

Section: Resultsmentioning

confidence: 97%

Antimalarial activity of some plants traditionally used in Meru district of Kenya

Muthaura

Rukunga

Chhabra

et al. 2007

Phytotherapy Research

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Ten plant extracts commonly used by the Meru community of Kenya were evaluated for the in vitro antiplasmodial, in vivo antimalarial, cytotoxicity and animal toxicity activities. The water and methanol extracts of Ludwigia erecta and the methanol extracts of Fuerstia africana and Schkuhria pinnata exhibited high antiplasmodial activity (IC(50) < 5 microg/mL) against chloroquine sensitive (D6) and resistant (W2) Plasmodium falciparum clones. The cytotoxicity of these highly active extracts on Vero E6 cells were in the range 161.5-4650.0 microg/mL with a selectivity index (SI) of 124.2-3530.7. In vivo studies of these extracts showed less activity with chemosuppression of parasitaemia in Plasmodium berghei infected mice of 49.64-65.28%. The methanol extract of Clerodendrum eriophyllum with a lower in vitro activity (IC(50) 9.51-10.56 microg/mL) exhibited the highest chemosuppression of 90.13%. The methanol and water extracts of Pittosporum viridiflorum were toxic to mice but at a lower dose prolonged survival of P. berghei infected mice (p < 0.05) with no overt signs of toxicity. However, the extracts were cytotoxic (SI, 0.96-2.51) on Vero E6 cells. These results suggest that there is potential to isolate active non-toxic antimalarial principles from these plants.

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Section: Resultsmentioning

confidence: 97%

Antimalarial activity of some plants traditionally used in Meru district of Kenya

Muthaura

Rukunga

Chhabra

et al. 2007

Phytotherapy Research

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“…The mortality rate of 0% at a dose of 100 mg/kg gradually rose to 100% at 8000 mg/kg, the highest dose studied. The no-observed-adverse-effect level for the intraperitoneal dose was 500 mg/kg, while the lowest-observed-effects level was 750 mg/kg (Alexeeff et al, 2002). Some adverse effects, such as hypoactivity and salivation, were seen immediately after intraperitoneal injection, while others (e.g., anorexia and weight loss) were observed later, and were more pronounced at the highest doses and persisted until death ( Table 2).…”

Section: Acute Toxicity Studiesmentioning

confidence: 97%

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Taïwé¹,

Bum

Talla

et al. 2010

Pharmaceutical Biology

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“…11,12 In the acute toxicity study, dosages upto1,000 mg/kg did not exhibit any mortality or any signs of toxicity (e.g., changes in body weight and the sum of food consumption) after oral administration of a single dose (Figure 1). This dosage might be considered as the no observed adverse effect level (NOAEL) 8 for DPSUU III. We inspected whether DPSUU III could suppress tumor growth in vivo.…”

Section: Resultsmentioning

confidence: 99%

“…As seen in (Figure 6), DPSUU III uniquely suppressed proliferation of MCF-7 cells at 250 and 500 μg/mL ( Figure 6) (p< 0.05 vs. control).0. 8,11,12 To explain the mechanism of cell growth inhibition by the DPSUU III plant complex, we determined its effect on cell cycle distribution. Exposure of MCF-7 cells to the DPSUU III plant complex resulted in the improvement of the G0-G1 fraction, which was accompanied by a decrease in the S phase ( Figure 7).…”

Section: Resultsmentioning

confidence: 99%

Pharmacognostic Evaluation of DPSUU III IN Breast Tumor Growth By G0/G1 Cell Cycle Arrest

Pradhan¹,

Dasmohapatra²,

Tripathy³

2017

IJPER

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Objective: Plant-inferred bioactive particles have been utilized to turn away or treat tumor for a considerable length of time. As of late plant blends were found to have significantly more grounded exercises than utilizing plant alone. In this study, we evaluated the anticancer impacts of DPSUU III which contains a mix of plant concentrates of Beta vulgaris, Syzygium cumini, Limonia acidissima. Material and Methods: After extraction from these plants, DPSUU III was granulated and powder was extricated with 80% ethanol, dried by rotating evaporator under vacuum and put away until utilize. DPSUU III was offered orally to mice at single measurements of 1000mg/kg/day alongside vehicle control and creatures were seen amid the initial 12 hr for any change in side effects of mobility, posture, amount of sustenance utilization and for mortality after MCF-7 cells were infused into mammary cushion of C57BL6 mice to create strong breast tumours. Then DPSUU III treated gathering was contrasted with the doxorubicin (Dox)-treated gathering. Results: The breast disease development was altogether stifled in mice treated with DPSUU III without loss of body weight and any symptoms while Dox-treated mice showed huge body weight reduction with little measure of toxicities. An expansion in life expectancy (ILS% = 62.80%) was seen in the DPSUU III -controlled gathering, contrasted with the tumor control bunch. DPSUU III shows hostile to proliferative movement against MCF-7 breast tumor cells through actuating G0/G1 cell cycle capture. DPSUU III hinders the declaration of cyclin D1, CDK4, CDK2 and prompts p21. Conclusion: DPSUU III could be a potential chemo preventive supplement to breast tumor patients.

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Characterization of the LOAEL-to-NOAEL Uncertainty Factor for Mild Adverse Effects from Acute Inhalation Exposures

Cited by 57 publications

References 15 publications

Antimalarial activity of some plants traditionally used in Meru district of Kenya

Antimalarial activity of some plants traditionally used in Meru district of Kenya

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Pharmacognostic Evaluation of DPSUU III IN Breast Tumor Growth By G0/G1 Cell Cycle Arrest

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