1989
DOI: 10.1016/s0040-4020(01)85785-9
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Characterizationf of autoxidation products of retinoic acid

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Cited by 35 publications
(25 citation statements)
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“…Form II sealed in ampoules under N 2 atmosphere and stored in a freezer is stable for more than 2 years. This behavior denotes the sensitivity of the form II to the oxidation of the cyclohexene ring 41,42. A proton NMR study10 reported a less restricted motion of the ring in the triclinic phase (II) that could be related to this polymorph's greater chemical reactivity to oxygen.…”
Section: Resultsmentioning
confidence: 99%
“…Form II sealed in ampoules under N 2 atmosphere and stored in a freezer is stable for more than 2 years. This behavior denotes the sensitivity of the form II to the oxidation of the cyclohexene ring 41,42. A proton NMR study10 reported a less restricted motion of the ring in the triclinic phase (II) that could be related to this polymorph's greater chemical reactivity to oxygen.…”
Section: Resultsmentioning
confidence: 99%
“…The driving force from CarO 3 to CarO 2 + is probably found in the linearization of the ring double bond with the polyene chain resulting in extended charge delocalization; in CarO 3 the distorted conformation of the dioxane ring prevents conjugation ( Figure 5 . [4,[13][14][15][16] A precise mechanistic discussion for endoperoxidation and hydride abstraction would be speculative at this juncture; Scheme 1 and Scheme 3 merely reconstruct a tentative train of thought to stimulate forthcoming verification studies. A possible not yet identified transient behind the so far overlooked small shoulder at 790 nm in Figure 1 may be significant in resolving mechanism and kinetic measurements.…”
Section: Resultsmentioning
confidence: 99%
“…Considering that the separation efficiency of GC was proven to be superior to that of HPLC, and that very little has been plubished on the use of GC to investigate isotretinoin in pharmaceuticals, the GC method was used for the analysis of isotretinoin samples submited to stability tests, using capillary columns of narrower diameter in comparison with traditional methods [29].…”
Section: Resultsmentioning
confidence: 99%