Characterizing the transmission properties of an ion funnel

Lynn, Eric C.; Chung, Ming-Chun; Han, Ching-Chih

doi:10.1002/1097-0231(20001130)14:22<2129::aid-rcm144>3.0.co;2-m

Cited by 40 publications

(39 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Shaffer et al, 1999), the detrimental action of the axial potential wells was independently confirmed (Lynn et al, 2000). Applying the Douglas ion-neutral collisional drag coefficient model (Chen et al, 1997) into the SIMION ion trajectory simulation package provided insights suggesting opening the exit rings to 2 mm i.d.…”

Section: Evolution Of the Ion Funnelmentioning

confidence: 79%

The ion funnel: Theory, implementations, and applications

Kelly

Tolmachev

Page

et al. 2009

Mass Spectrometry Reviews

253

267

View full text Add to dashboard Cite

The electrodynamic ion funnel has enabled the manipulation and focusing of ions in a pressure regime (0.1-30 Torr) that has challenged traditional approaches, and provided the basis for much greater mass spectrometer ion transmission efficiencies. The initial ion funnel implementations aimed to efficiently capture ions in the expanding gas jet of an electrospray ionization interface and radially focus them for efficient transfer through a conductance limiting orifice. We review the improvements in fundamental understanding of ion motion in ion funnels, the evolution in its implementations that have brought the ion funnel to its current state of refinement, as well as applications of the ion funnel for purposes such as ion trapping, ion cooling, low pressure electrospray, and ion mobility spectrometry. #

show abstract

Section: Evolution Of the Ion Funnelmentioning

confidence: 79%

The ion funnel: Theory, implementations, and applications

Kelly

Tolmachev

Page

et al. 2009

Mass Spectrometry Reviews

253

267

View full text Add to dashboard Cite

show abstract

“…This configuration was found by Lynn et al to provide superior transmission. 30 A dc potential gradient of 500 V was applied along the sequence of plates via a voltage divider comprising 22 M⍀ resistors. The rf potential was applied out of phase on alternating plates via capacitive coupling through 0.02 F capacitors and a matching network.…”

Section: B Ion Funnelmentioning

confidence: 99%

Development of an electrospray approach to deposit complex molecules on plasma modified surfaces

Kitching

Lee

Elam

et al. 2003

Review of Scientific Instruments

View full text Add to dashboard Cite

Two established techniques have been coupled to allow surfaces to be precision engineered. Electrospray ionization to bring large, complex, intact molecular ions into the gas phase has been interfaced with a radio frequency ͑rf͒ plasma reactor to treat surfaces making them receptive to the deposition of active biomolecules. The new instrument has been designed and used successfully to deposit a number of high molecular weight molecules including the polysaccharide, sodium hyaluronan ͑HA͒, that has an important role in a number of physiological functions. Substrate material is treated using a rf glow discharge plasma chamber, to clean and activate the surface in a controlled manner, then exposed to a beam of multiply charged ions in the gas phase that have been generated using electrospray techniques. The ions are deposited gently onto the substrate and become covalently bound. The molecular integrity and stability of HA surfaces prepared in this way was established using x-ray photoelectron spectroscopy, changes in the observed contact angle, time-of-flight secondary ion mass spectrometry, scanning electron microscopy, and a biological assay-platelet adhesion to the surface.

show abstract

“…The ion trajectory is typically treated with a free motion in electric field subsequently modified by stochastic Monte-Carlo collisions, typically used for static molecular flow model. This has been implemented in SIMION, [11][12][13] ITSIM, [13][14][15][16] ISIS, 13,17 and some other home written simulation programs. [18][19][20][21] Our recent study, however, has shown that the flowing motion of the gas molecules at pressures as low as 10 -5 Torr could have a significant impact on the trapping of the ions.…”

Section: Introductionmentioning

confidence: 99%

Following the Ions through a Mass Spectrometer with Atmospheric Pressure Interface: Simulation of Complete Ion Trajectories from Ion Source to Mass Analyzer

Zhou

Ouyang

2016

Anal. Chem.

View full text Add to dashboard Cite

Ion trajectory simulation is an important and useful tool in instrumentation development for mass spectrometry. Accurate simulation of the ion motion through the mass spectrometer with atmospheric pressure ionization source has been extremely challenging, due to the complexity in gas hydrodynamic flow field across a wide pressure range as well as the computational burden. In this study, we developed a method of generating the gas flow field for an entire mass spectrometer with an atmospheric pressure interface. In combination with the electric force, for the first time simulation of ion trajectories from an atmospheric pressure ion source to a mass analyzer in vacuum has been enabled. A stage-by-stage ion repopulation method has also been implemented for the simulation, which helped to avoid an intolerable computational burden for simulations at high pressure regions while it allowed statistically meaningful results obtained for the mass analyzer. It has been demonstrated to be suitable to identify a joint point for combining the high and low pressure fields solved individually. Experimental characterization has also been done to validate the new method for simulation. Good agreement was obtained between simulated and experimental results for ion transfer though an atmospheric pressure interface with a curtain gas.

show abstract

Characterizing the transmission properties of an ion funnel

Cited by 40 publications

References 15 publications

The ion funnel: Theory, implementations, and applications

The ion funnel: Theory, implementations, and applications

Development of an electrospray approach to deposit complex molecules on plasma modified surfaces

Following the Ions through a Mass Spectrometer with Atmospheric Pressure Interface: Simulation of Complete Ion Trajectories from Ion Source to Mass Analyzer

Contact Info

Product

Resources

About