Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin

Li, Xin; Laura, Hetjens; Wolter, Nadja; Li, Helin; Shi, Xiangyang; Pich, Andrij

doi:10.1016/j.jare.2022.02.014

Cited by 84 publications

(68 citation statements)

References 59 publications

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“…The MEK/ERK signaling pathway is mainly responsible for regulating the phosphorylation sites of activity. Integrin β1 accumulates in the perinuclear area and no longer returns to the plasma membrane (Raman and Cobb, 2003;Shaul and Seger, 2007;Lee et al, 2014;Li et al, 2022). At the same time, integrin β3 is not affected by the action of the exosome.…”

Section: Macrophagementioning

confidence: 99%

Osteoimmunomodulation role of exosomes derived from immune cells on osseointegration

Xiao

Ding

Zhuang

et al. 2022

Front. Bioeng. Biotechnol.

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Despite the high success rate of biomedical implants adopted clinically, implant failures caused by aseptic loosening still raise the risk of secondary surgery and a substantial economic burden to patients. Improving the stable combination between the implant and the host bone tissue, achieving fast and high-quality osseointegration can effectively reduce the probability of aseptic loosening. Accumulating studies have shown that the osteoimmunomodulation mediated by immune cells mainly dominated by macrophages plays a pivotal role in osseointegration by releasing active factors to improve the inflammatory microenvironment. However, the mechanism by which osteoimmunomodulation mediates osseointegration remains unclear. Recent studies have revealed that exosomes released by macrophages play a central role in mediating osteoimmunomodulation. The exosomes can be internalized by various cells participating in de novo bone formation, such as endothelial cells and osteoblasts, to intervene in the osseointegration robustly. Therefore, macrophage-derived exosomes with multifunctionality are expected to significantly improve the osseointegration microenvironment, which is promising in reducing the occurrence of aseptic loosening. Based on this, this review summarizes recent studies on the effects of exosomes derived from the immune cells on osseointegration, aiming to provide a theoretical foundation for improving the clinical success rate of biomedical implants and achieving high-quality and high-efficiency osseointegration.

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Section: Macrophagementioning

confidence: 99%

Osteoimmunomodulation role of exosomes derived from immune cells on osseointegration

Xiao

Ding

Zhuang

et al. 2022

Front. Bioeng. Biotechnol.

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“…In biomedicine, the three-dimensional (3D) network structure of nanocellulose-based hydrogels is similar to that of human tissues. Additionally, nanocellulose-based hydrogels have good mechanical properties, biocompatibility and renderability, which makes them widely used in the fields of drug delivery, tissue engineering, trauma dressing and wearable sensors [89][90][91][92][93][94][95][96]. Liu et al [97] added aminated silver nanoparticles (Ag-NH2NPs) and gelatin (G) to TOCNF.…”

Section: Hydrogels In Biomedicinementioning

confidence: 99%

Preparation and application of cellulose-based hydrogels derived from bamboo

Chen

et al. 2022

Preprint

Self Cite

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Hydrogels have outstanding research and application prospects in various fields. Among them, the design and preparation of cellulose-based functional hydrogels derived from bamboo have attracted increasing research interest. Cellulose-based hydrogels not only have the skeleton function of hydrogels, but also retain excellent specificity, smart structural design, precise molecular recognition ability, and superior biocompatibility. Cellulose-based hydrogels show important application prospects in various fields such as environmental protection, biomedicine, energy, food packaging and plant agriculture. Recently, researchers have extracted cellulose from bamboo and generated a variety of cellulose-based functional hydrogels with excellent properties by various cross-linking methods. In addition, a variety of multifunctional hybrid cellulose-based hydrogels have been constructed by introducing functional components or combining them with other functional materials, expanding the breadth and depth of their applications. Herein, we elaborate advances in the field of cellulose-based hydrogels and highlight their applications in various fields. Meanwhile, the existing problems and prospects are summarized. The review provides a reference for further development of cellulose-based hydrogels.

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“…Biomimetic superhydrophobic surfaces, which are prepared by using the superhydrophobic phenomena related to biological structures in nature (Table 1), such as lotus leaves (Sun and Guo, 2019;Lv et al, 2020), butterfly wings (Zheng et al, 2007;Shao et al, 2019) and rice leaves (Wu et al, 2011;Lee et al, 2013;Rius-Ayra et al, 2018), have attracted wide attention and research because of outstanding self-cleaning (Barthlott and Neinhuis, 1997;Fürstner et al, 2005;Ming et al, 2005), anti-icing (Liu et al, 2020;Sun et al, 2020), anti-corrosion (Liu et al, 2014;Wei et al, 2021a;Zhang et al, 2022), and oil-water separation (Wang et al, 2015a;Saleh et al, 2020;Rasouli et al, 2021;Yao et al, 2021) properties. In recent years, with the deepening of the research in the micro-field, micro-nano materials have developed rapidly, and they have been developed into intelligent responsiveness (Li et al, 2017a;Chang et al, 2018;Li et al, 2021a), environmental remediation (Kumari et al, 2019;Sajjadi et al, 2021), biodegradability (Li et al, 2021b;Li et al, 2022a;Li et al, 2022b), nano-probe imaging (Li et al, 2016;Li et al, 2017b;Li et al, 2019a;Li et al, 2022c), and other characteristics, which are widely used in many fields (Waked, 2011;Khandelwal et al, 2016;Scalisi, 2017;Li et al, 2019b;Siddiqui et al, 2019), especially medicine…”

Section: Introductionmentioning

confidence: 99%

Biomimetic superhydrophobic metal/nonmetal surface manufactured by etching methods: A mini review

Ge-Zhang

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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As an emerging fringe science, bionics integrates the understanding of nature, imitation of nature, and surpassing nature in one aspect, and it organically combines the synergistic complementarity of function and structure–function integrated materials which is of great scientific interest. By imitating the microstructure of a natural biological surface, the bionic superhydrophobic surface prepared by human beings has the properties of self-cleaning, anti-icing, water collection, anti-corrosion and oil–water separation, and the preparation research methods are increasing. The preparation methods of superhydrophobic surface include vapor deposition, etching modification, sol–gel, template, electrostatic spinning, and electrostatic spraying, which can be applied to fields such as medical care, military industry, ship industry, and textile. The etching modification method can directly modify the substrate, so there is no need to worry about the adhesion between the coating and the substrate. The most obvious advantage of this method is that the obtained superhydrophobic surface is integrated with the substrate and has good stability and corrosion resistance. In this article, the different preparation methods of bionic superhydrophobic materials were summarized, especially the etching modification methods, we discussed the detailed classification, advantages, and disadvantages of these methods, and the future development direction of the field was prospected.

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Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin

Cited by 84 publications

References 59 publications

Osteoimmunomodulation role of exosomes derived from immune cells on osseointegration

Osteoimmunomodulation role of exosomes derived from immune cells on osseointegration

Preparation and application of cellulose-based hydrogels derived from bamboo

Biomimetic superhydrophobic metal/nonmetal surface manufactured by etching methods: A mini review

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