Chemical and Potential Biological Perspectives of Genus Sarcococca (Buxaceae)

Kumar, Anoop; Sati, Satish Chandra; Sati, Manisha Dobhal; Kumar, Sudhir; Singh, Darshan; Bhatt, Upendra; Kaur, Gurpreet

doi:10.2174/2210315505666150219233014

Cited by 12 publications

(3 citation statements)

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“…Studies show that S. hookeriana has many biological activities, such as cholinesterase inhibitory effect [5], immunosuppression and liver protection [6], and antibacterial effect [7]. Its main chemical component is pregnenic-type steroidal alkaloids [8]. S. hookeriana has been used as folk medicine in Asia areas for a long time to treat stomach diseases and so on.…”

Section: Commentmentioning

confidence: 99%

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Ning

Yang

2020

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Commentmentioning

confidence: 99%

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Ning

Yang

2020

Zeitschrift Für Kristallographie - New Crystal Structures

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“…The S.hookeriana possess a variety of bioactivity. A recently reported experimental study shows that the main chemical compositions of S.hookeriana are pregnane-type steroidal alkaloids [5]. These compounds have shown cholinesterase inhibition [6], and they poved antileishmanial [7], antibacterial [8] and estrogen biosynthesis-promoting [9] activities.…”

Section: Commentmentioning

confidence: 99%

Crystal structure of N-((3R,10S,13S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methylbenzamide, C₃₁H₄₈N₂O

Tan

et al. 2019

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Similarly, leaves and shoots of Sarcococca plants have been used for the treatment of rheumatic fever in folk medicine [9]. Whole parts of this medicinally important plant roots, stem, leaves, bark, and flowers have been continuously under multidimensional intense research for years.…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase and α-Amylase Inhibition Activities of Sarcococca coriacea Hook. And Sarcococca wallichii Staph. of Nepalese Origin

Baral

Shrestha

Adhikari

2022

J. Nepal Chem. Soc.

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Diabetes mellitus is being severe health problem globally with an increasing number of patients every day. Due to the lack of effective and non-toxic medicine to cure diabetes, plants that are used in ethnomedicine may be a good source for antidiabetic drug discovery. Plants of the Sarcococca genus are medicinally important and are used by local people for managing many diseases including diabetes. In the course of our continuous search of antidiabetic plants and pure compounds, in vitro α-glucosidase, and α-amylase inhibition activity along with the antioxidant activity of methanolic extract of S. coriacea leaf ( Sc-A), S. coriacea stem (Sc-B), and dichloromethane fraction of methanolic extract of Sarcococca wallichi (Sw-D) were carried out. The research revealed dicholoromethane fraction of S. wallichii (Sw-D) with good inhibition of α- amylase enzyme (IC50= 53.79 ± 2.50), whereas Sc-B inhibits α-glucosidase (20.97±2.37) effectively. Similarly, Sc-A showed significant antioxidant activity with IC50=24.56±3.3. The total phenolic content on Sc-A and Sc-B was calculated as 151.35±4.42 mg GAE/g and 86.22±1.59 mg GAE/g whereas the total flavonoid content on Sc-A and Sc-B was found to be 21.61±4.88 mg QE/g and 24.09±4.02 mg QE/g respectively. Similarly, total phenolic and total flavonoid content on Sw-D were found to be 85.26±3.16 mg GAE/g and 21.57±1.26 mg QE/g. To the best of our knowledge, this is the first report of α-glucosidase and α-amylase inhibition activity in these plants. This research work has scientifically supported the use of these plants to manage diabetes by local people and has explored new plants for antidiabetic drug discovery research.

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Chemical and Potential Biological Perspectives of Genus Sarcococca (Buxaceae)

Cited by 12 publications

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Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Crystal structure of N-((3R,10S,13S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methylbenzamide, C₃₁H₄₈N₂O

α-Glucosidase and α-Amylase Inhibition Activities of Sarcococca coriacea Hook. And Sarcococca wallichii Staph. of Nepalese Origin

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Chemical and Potential Biological Perspectives of Genus Sarcococca (Buxaceae)

Cited by 12 publications

References 0 publications

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C24H46ClNO5

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C24H46ClNO5

Crystal structure of N-((3R,10S,13S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methylbenzamide, C31H48N2O

α-Glucosidase and α-Amylase Inhibition Activities of Sarcococca coriacea Hook. And Sarcococca wallichii Staph. of Nepalese Origin

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Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Crystal structure of (1S)-N-(chloromethyl)-1-((4S,6aR,8aS, 8bR,9aR)-4-methoxy-6a,8a-dimethyl-1,3,4, 5,6,6a,6b,7,8,8a,9a,10,10a,10b-tetradecahydro-8bH-naphtho[2′,1′:4,5] indeno[1,2-b]oxiren-8b-yl)-N-methylethan-1-amine, C₂₄H₄₆ClNO₅

Crystal structure of N-((3R,10S,13S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methylbenzamide, C₃₁H₄₈N₂O